scholarly journals Sinus Histiocytosis

2020 ◽  
Author(s):  
Keyword(s):  
Sinus Histiocytosis

scholarly journals Sinus Histiocytosis with Massive Lymphadenopathy

1980 ◽  
Vol 30 (1) ◽  
pp. 55-58 ◽  
Author(s):  
J. Dearth ◽  
D. Hunter ◽  
D. Kelly ◽  
W. Crist
Keyword(s):  
Sinus Histiocytosis ◽  
Massive Lymphadenopathy

108: Sinus Histiocytosis: A Rare Cause of Rapidly Progressive Pediatric Cervical Adenopathy

1996 ◽  
Vol 115 (2) ◽  
pp. P193-P193
Author(s):  
John M. Lasak ◽  
Diran O. Mikaeuan ◽  
Peter McCue
Keyword(s):  
Sinus Histiocytosis

Multifocal, Extranodal Sinus Histiocytosis With Massive Lymphadenopathy: An Overview

2007 ◽  
Vol 131 (7) ◽  
pp. 1117-1121 ◽  
Author(s):  
Sujata Gaitonde
Keyword(s):  
Current Knowledge ◽  
Clinical Manifestations ◽  
Patient Characteristics ◽  
Sinus Histiocytosis ◽  
Massive Lymphadenopathy ◽  
Immune Mediated ◽  
Pathologic Features ◽  
Extranodal Disease ◽  
Children And Young Adults ◽  
Histopathologic Features

Abstract Context.—This article provides an overview of the major pathologic manifestations of sinus histiocytosis with massive lymphadenopathy, including patient characteristics and current knowledge about its pathogenesis, with an emphasis on multifocal and extranodal presentation. Sinus histiocytosis with massive lymphadenopathy is a rare, nonneoplastic, idiopathic, proliferative histiocytic disorder; recognition of this disorder is important to avoid misinterpretation and subsequent unnecessary treatment. This is especially true for primary extranodal manifestation of this rare disorder. Although accurate diagnosis of this entity requires a correlation of clinical, radiologic, laboratory, and pathologic studies in most cases, it remains a disorder primarily defined by its histopathologic features and pathologic manifestations, which are key to the diagnosis. Objective.—To summarize the scientific literature, provide a concise review, and emphasize the diagnostic histopathologic features of extranodal sinus histiocytosis with massive lymphadenopathy. Data Sources.—A comprehensive literature review was undertaken to summarize the clinical and pathologic features of this disorder. Conclusions.—Sinus histiocytosis with massive lymphadenopathy is characterized by a rare, acquired, nonmalignant proliferation of distinctive histiocytes that present with lymphadenopathy or extranodal disease, primarily in children and young adults. It exhibits a broad range of clinical presentations, thus eliciting a wide differential diagnosis. The diverse clinical manifestations and frequent association with subtle or severe immunologic abnormalities suggest an immune-mediated cause. Additional studies are needed to characterize the interplay between death receptors and cytotoxic mediators and to further elucidate the loss of immune hemostasis that may underlie idiopathic histiocytic proliferations such as this.

Primary Pancreatic Sinus Histiocytosis With Massive Lymphadenopathy (Rosai-Dorfman Disease): An Unusual Extranodal Manifestation Clinically Simulating Malignancy

2010 ◽  
Vol 134 (2) ◽  
pp. 276-278 ◽  
Author(s):  
Mark Podberezin ◽  
Ronald Angeles ◽  
Grace Guzman ◽  
David Peace ◽  
Sujata Gaitonde
Keyword(s):  
Adipose Tissue ◽  
Lymph Node ◽  
Unusual Case ◽  
Sinus Histiocytosis ◽  
Gastrointestinal System ◽  
Rare Entity ◽  
Massive Lymphadenopathy ◽  
Rosai Dorfman Disease

Abstract Sinus histiocytosis with massive lymphadenopathy (SHML), also called Rosai-Dorfman disease, is a rare entity. Its etiology and pathogenesis are still essentially unclear. The histologic hallmark of this disease is proliferation of distinctive histiocytes within lymph node sinuses and in extranodal sites. Approximately 23% of patients with SHML, documented in the SHML Registry, presented with disease primarily in extranodal sites, and very few cases of SHML (<1%) involving the gastrointestinal system have been described in the literature. We report an unusual case of primary pancreatic SHML with infiltration of the process into peripancreatic, perinephric, and perisplenic adipose tissue, simulating malignancy.

Sign in / Sign up

Export Citation Format

Share Document