Conventional Osteosarcoma

2020 ◽  
Author(s):  
Keyword(s):  
Conventional Osteosarcoma

scholarly journals Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

10.3791/53884 ◽  
2016 ◽  
Author(s):  
Gaia Palmini ◽  
Roberto Zonefrati ◽  
Carmelo Mavilia ◽  
Alessandra Aldinucci ◽  
Ettore Luzi ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Cultures ◽  
Conventional Osteosarcoma

Conventional Osteosarcoma

2017 ◽  
pp. 32-51
Author(s):  
G. Petur Nielsen ◽  
Andrew E. Rosenberg ◽  
Vikram Deshpande ◽  
Francis J. Hornicek ◽  
Susan V. Kattapuram ◽  
...  
Keyword(s):  
Conventional Osteosarcoma

scholarly journals Spontaneous conventional osteosarcoma transformation of a chondroblastoma: A case report and literature review

2018 ◽  
Vol 52 (1) ◽  
pp. 87 ◽  
Author(s):  
Prashant Narhari ◽  
Amber Haseeb ◽  
Serene Lee ◽  
VivekAjit Singh
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Conventional Osteosarcoma

A clinical comparison between dedifferentiated low-grade osteosarcoma and conventional osteosarcoma

2019 ◽  
Vol 101-B (6) ◽  
pp. 745-752 ◽  
Author(s):  
S. Toki ◽  
E. Kobayashi ◽  
A. Yoshida ◽  
K. Ogura ◽  
S. Wakai ◽  
...  
Keyword(s):  
Progression Free Survival ◽  
Poor Response ◽  
Distant Metastases ◽  
Histological Evaluation ◽  
Low Grade ◽  
Cyclin Dependent Kinase ◽  
Free Survival ◽  
Standard Chemotherapy Regimen ◽  
Conventional Osteosarcoma ◽  
High Grade Osteosarcoma

Aims The purpose of this study was to clarify the clinical behaviour, prognosis, and optimum treatment of dedifferentiated low-grade osteosarcoma (DLOS) diagnosed based on molecular pathology. Patients and Methods We retrospectively reviewed 13 DLOS patients (six men, seven women; median age 32 years (interquartile range (IQR) 27 to 38)) diagnosed using the following criteria: the histological coexistence of low-grade and high-grade osteosarcoma components in the lesion, and positive immunohistochemistry of mouse double minute 2 homolog (MDM2) and cyclin-dependent kinase 4 (CDK4) associated with MDM2 amplification. These patients were then compared with 51 age-matched consecutive conventional osteosarcoma (COS) patients (33 men, 18 women; median age 25 years (IQR 20 to 38)) regarding their clinicopathological features. Results The five-year overall survival (OAS) rates in the DLOS and COS patients were 85.7% and 77.1% (p = 0.728), respectively, and the five-year progression-free survival (PFS) rates were 57.7% and 44.9% (p = 0.368), respectively. A total of 12 DLOS patients received chemotherapy largely according to regimens for COS. Among the nine cases with a histological evaluation after chemotherapy, eight showed a poor response, and seven of these had a necrosis rate of < 50%. One DLOS patient developed local recurrence and five developed distant metastases. Conclusion Based on our study of 13 DLOS cases that were strictly defined by histological and molecular means, DLOS showed a poorer response to a standard chemotherapy regimen than COS, while the clinical outcomes were not markedly different. Cite this article: Bone Joint J 2019;101-B:745–752.

scholarly journals RUNX2 and WWOX genes as molecular biomarkers and candidates for targeted therapy in Egyptian patients with primary conventional osteosarcoma

2016 ◽  
Vol 36 (1) ◽  
Author(s):  
Abeer A. Bahnassy ◽  
Eman Abdelzaher ◽  
Rania Gaber ◽  
Gamal Elhosseiny ◽  
Awad Abdel Moniem A. Rafalla ◽  
...  
Keyword(s):  
Targeted Therapy ◽  
Molecular Biomarkers ◽  
Egyptian Patients ◽  
Conventional Osteosarcoma

High-Grade Conventional Osteosarcoma of the Mandible Associated With P53 Germline Mutation

2018 ◽  
Vol 29 (3) ◽  
pp. 738-740 ◽  
Author(s):  
Daniel Ginat ◽  
Jefree Schulte ◽  
Zhen Gooi ◽  
Nicole Cipriani
Keyword(s):  
Germline Mutation ◽  
High Grade ◽  
Conventional Osteosarcoma

Well-differentiated intra-osseous osteosarcoma in the mandible of a six-year-old child

1990 ◽  
Vol 104 (4) ◽  
pp. 335-340 ◽  
Author(s):  
P. L. James ◽  
M. B. O'regan ◽  
P. M. Speight
Keyword(s):  
Differential Diagnosis ◽  
Surgical Removal ◽  
High Grade ◽  
Large Tumour ◽  
Desmoplastic Fibroma ◽  
Subsequent Transformation ◽  
Surgical Access ◽  
Conventional Osteosarcoma ◽  
Well Differentiated ◽  
The Relationship

AbstractThe case of an osteosarcoma arising in the mandible of a six-year-old child is presented. It was originally misdiagnosed as a desmoplastic fibroma, and after initial curettage continued to grow for twelve years. The differential diagnosis is presented and details of the surgical access and difficulties encountered in the surgical removal of this very large tumour are described.The relationship between pre-existing disease and osteosarcoma of the mandible is discussed, and the difficulties experienced in distinguishing between the fibro-osseous lesions and osteosarcoma of the mandible are highlighted.The case is presented as a well-differentiated, intra-osseous osteosarcoma with subsequent transformation into a high-grade, conventional osteosarcoma.

scholarly journals Correlation between ERK1 and STAT3 expression and chemoresistance in patients with conventional osteosarcoma

BMC Cancer ◽  
2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Sébastien Salas ◽  
Carine Jiguet-Jiglaire ◽  
Loic Campion ◽  
Catherine Bartoli ◽  
Frédéric Frassineti ◽  
...  
Keyword(s):  
Conventional Osteosarcoma

Parosteal Osteosarcoma

2014 ◽  
Vol 138 (5) ◽  
pp. 694-699 ◽  
Author(s):  
Jen-Fan Hang ◽  
Paul Chih-Hsueh Chen
Keyword(s):  
Benign Tumors ◽  
Parosteal Osteosarcoma ◽  
Prognostic Variables ◽  
Pathologic Features ◽  
Conventional Osteosarcoma ◽  
Microscopic Morphology ◽  
Slow Growing ◽  
Diagnostic Pitfalls ◽  
Metaphyseal Region ◽  
Better Than

Parosteal osteosarcoma is a rare malignant bone tumor arising from the bone cortical surface. It most commonly occurs in young women over the metaphyseal region, especially the long bones near the knee joint. Patients usually report a slow-growing mass for years. The tumor is characterized by its bland microscopic morphology, prone to be misdiagnosed as other benign tumors. In the absence of dedifferentiation, the prognosis is generally better than that of conventional osteosarcoma. Recent studies demonstrated distinctive cytogenetic abnormality resulting in amplification of the CDK4 and MDM2 genes, which may serve as markers for molecular diagnosis. In this article, we review the clinical, radiologic, and pathologic features of parosteal osteosarcoma and identify some diagnostic pitfalls, discuss the prognostic variables, and update recent molecular advances and their application in the diagnosis.

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