scholarly journals Complement Decay-Accelerating Factor

2020 ◽  
Author(s):  
Keyword(s):  
Decay Accelerating Factor

scholarly journals Complement Inactivation Strategy of Staphylococcus aureus Using Decay-Accelerating Factor and the Response of Infected HaCaT Cells

2021 ◽  
Vol 22 (8) ◽  
pp. 4015
Author(s):  
Kyoung Ok Jang ◽  
Youn Woo Lee ◽  
Hangeun Kim ◽  
Dae Kyun Chung
Keyword(s):  
Staphylococcus Aureus ◽  
Immune Cells ◽  
Respiratory Infections ◽  
Food Poisoning ◽  
Surface Expression ◽  
Host Cells ◽  
Hacat Cells ◽  
Decay Accelerating Factor ◽  
Ligand Expression ◽  
The Complement System

Staphylococcus aureus is a species of Gram-positive staphylococcus. It can cause sinusitis, respiratory infections, skin infections, and food poisoning. Recently, it was discovered that S. aureus infects epithelial cells, but the interaction between S. aureus and the host is not well known. In this study, we confirmed S. aureus to be internalized by HaCaT cells using the ESAT-6-like protein EsxB and amplified within the host over time by escaping host immunity. S. aureus increases the expression of decay-accelerating factor (CD55) on the surfaces of host cells, which inhibits the activation of the complement system. This mechanism makes it possible for S. aureus to survive in host cells. S. aureus, sufficiently amplified within the host, is released through the initiation of cell death. On the other hand, the infected host cells increase their surface expression of UL16 binding protein 1 to inform immune cells that they are infected and try to be eliminated. These host defense systems seem to involve the alteration of tight junctions and the induction of ligand expression to activate immune cells. Taken together, our study elucidates a novel aspect of the mechanisms of infection and immune system evasion for S. aureus.

Location of WESbon decay-accelerating factor

Transfusion ◽  
1995 ◽  
Vol 35 (3) ◽  
pp. 278-278 ◽  
Author(s):  
Marilyn J. Telen ◽  
Neeraja Rao ◽  
Douglas M. Lublin
Keyword(s):  
Decay Accelerating Factor

Relative Contributions of Decay Accelerating Factor (DAF), Membrane Cofactor Protein (MCP) and CD59 in the Protection of Melanocytes from Homologous Complement

Immunobiology ◽  
1998 ◽  
Vol 198 (4) ◽  
pp. 476-484 ◽  
Author(s):  
Gerhard T. Venneker ◽  
Robert M. Vodegel ◽  
Norico Okada ◽  
Wiete Westerhof ◽  
Jan D. Bos ◽  
...  
Keyword(s):  
Membrane Cofactor Protein ◽  
Decay Accelerating Factor

Increased expression of decay-accelerating factor (CD55) in the inflamed mucosa of patients with ulcerative colitis

1998 ◽  
Vol 5 (2) ◽  
pp. 105-110 ◽  
Author(s):  
Akira Andoh ◽  
Yoshihide Fujiyama ◽  
Toshio Kimura ◽  
Takao Saotome ◽  
Tomoyuki Tsujikawa ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Decay Accelerating Factor

Polymorphic expression of decay‐accelerating factor in human colorectal cancer

2001 ◽  
Vol 16 (2) ◽  
pp. 184-189 ◽  
Author(s):  
Masahiro Nakagawa ◽  
Motowo Mizuno ◽  
Mikihiro Kawada ◽  
Tokurou Uesu ◽  
Junichirou Nasu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Human Colorectal Cancer ◽  
Decay Accelerating Factor

Identification of a factor B site involved in the dissociation of the AP C3 convertase by decay accelerating factor

2000 ◽  
Vol 49 (1-2) ◽  
pp. 64
Author(s):  
Lynne Mitchell ◽  
Lisa Kuttner-Kondo ◽  
M.Edward Medof ◽  
Dennis Hourcade
Keyword(s):  
Decay Accelerating Factor ◽  
Factor B
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