scholarly journals 2-Fluoropropionyl-labeled Pegylated Dimeric RGD Peptide

2020 ◽  
Author(s):  
Keyword(s):  
Rgd Peptide ◽  
Dimeric Rgd Peptide

scholarly journals Imaging integrin alpha-v-beta-3 expression in tumors with an18F-labeled dimeric RGD peptide

2013 ◽  
Vol 8 (3) ◽  
pp. 238-245 ◽  
Author(s):  
Ingrid Dijkgraaf ◽  
Samantha Y. A. Terry ◽  
William J. McBride ◽  
David M. Goldenberg ◽  
Peter Laverman ◽  
...  
Keyword(s):  
Rgd Peptide ◽  
Dimeric Rgd Peptide ◽  
Alpha V Beta 3

scholarly journals Micro-PET Imaging of αvβ3-Integrin Expression with 18F-Labeled Dimeric RGD Peptide

2004 ◽  
Vol 3 (2) ◽  
pp. 96-104 ◽  
Author(s):  
Xiaoyuan Chen ◽  
Michel Tohme ◽  
Ryan Park ◽  
Yingping Hou ◽  
James R. Bading ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Rgd Peptide ◽  
Integrin Expression ◽  
Dimeric Rgd Peptide

scholarly journals Synthesis and Evaluation of a Dimeric RGD Peptide as a Preliminary Study for Radiotheranostics with Radiohalogens

Molecules ◽  
2021 ◽  
Vol 26 (20) ◽  
pp. 6107
Author(s):  
Hiroaki Echigo ◽  
Kenji Mishiro ◽  
Takeshi Fuchigami ◽  
Kazuhiro Shiba ◽  
Seigo Kinuya ◽  
...  
Keyword(s):  
Single Injection ◽  
Rgd Peptide ◽  
Αvβ3 Integrin ◽  
High Accumulation ◽  
Rgd Peptides ◽  
Dimeric Rgd Peptide ◽  
Tumor Tissues ◽  
Preliminary Study ◽  
Labeling Method ◽  
Alpha Therapy

We recently developed 125I- and 211At-labeled monomer RGD peptides using a novel radiolabeling method. Both labeled peptides showed high accumulation in the tumor and exhibited similar biodistribution, demonstrating their usefulness for radiotheranostics. This study applied the labeling method to a dimer RGD peptide with the aim of gaining higher accumulation in tumor tissues based on improved affinity with αvβ3 integrin. We synthesized an iodine-introduced dimer RGD peptide, E[c(RGDfK)] (6), and an 125/131I-labeled dimer RGD peptide, E[c(RGDfK)]{[125/131I]c[RGDf(4-I)K]} ([125/131I]6), and evaluated them as a preliminary step to the synthesis of an 211At-labeled dimer RGD peptide. The affinity of 6 for αvβ3 integrin was higher than that of a monomer RGD peptide. In the biodistribution experiment at 4 h postinjection, the accumulation of [125I]6 (4.12 ± 0.42% ID/g) in the tumor was significantly increased compared with that of 125I-labeled monomer RGD peptide (2.93 ± 0.08% ID/g). Moreover, the accumulation of [125I]6 in the tumor was greatly inhibited by co-injection of an excess RGD peptide. However, a single injection of [131I]6 (11.1 MBq) did not inhibit tumor growth in tumor-bearing mice. We expect that the labeling method for targeted alpha therapy with 211At using a dimer RGD peptide could prove useful in future clinical applications.

scholarly journals Micro-PET Imaging of α v β 3 -Integrin Expression with 18 F-Labeled Dimeric RGD Peptide

2004 ◽  
Vol 3 (2) ◽  
pp. 153535002004041 ◽  
Author(s):  
Xiaoyuan Chen ◽  
Michel Tohme ◽  
Ryan Park ◽  
Yingping Hou ◽  
James R. Bading ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Rgd Peptide ◽  
Integrin Expression ◽  
Dimeric Rgd Peptide

A novel concept of radiosynthesis of a 99mTc-labeled dimeric RGD peptide as a potential radiotracer for tumor imaging

2013 ◽  
Vol 23 (6) ◽  
pp. 1808-1812 ◽  
Author(s):  
Sweety Mittal ◽  
Mohini Bhadwal ◽  
Sudipta Chakraborty ◽  
H.D. Sarma ◽  
Sharmila Banerjee ◽  
...  
Keyword(s):  
Tumor Imaging ◽  
Rgd Peptide ◽  
Dimeric Rgd Peptide ◽  
Novel Concept

scholarly journals N-Succinimidyl 4-[18F]-fluoromethylbenzoate-labeled dimeric RGD peptide for imaging tumor integrin expression

Amino Acids ◽  
2011 ◽  
Vol 43 (3) ◽  
pp. 1349-1357 ◽  
Author(s):  
Weihua Li ◽  
Lixin Lang ◽  
Gang Niu ◽  
Ning Guo ◽  
Ying Ma ◽  
...  
Keyword(s):  
Rgd Peptide ◽  
Integrin Expression ◽  
Dimeric Rgd Peptide

scholarly journals Hybrid PET/optical imaging of integrin αVβ3 receptor expression using a 64Cu-labeled streptavidin/biotin-based dimeric RGD peptide

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Choong Mo Kang ◽  
Hyun-Jung Koo ◽  
Gwang Il An ◽  
Yearn Seong Choe ◽  
Joon Young Choi ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Integrin Αvβ3 ◽  
Rgd Peptide ◽  
Receptor Expression ◽  
Dimeric Rgd Peptide ◽  
Αvβ3 Receptor
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