scholarly journals Immune Response Regulation Pathway

2020 ◽  
Author(s):  
Keyword(s):  
Immune Response ◽  
Immune Response Regulation

Immune Response: Regulation

2002 ◽  
Author(s):  
Miodrag L Lukic ◽  
Aleksandra M Lukic
Keyword(s):  
Immune Response ◽  
Immune Response Regulation

scholarly journals Innate Immune Response Regulation by the Human RNASET2 Tumor Suppressor Gene

2019 ◽  
Vol 10 ◽  
Author(s):  
Francesco Acquati ◽  
Lorenzo Mortara ◽  
Annarosaria De Vito ◽  
Denisa Baci ◽  
Adriana Albini ◽  
...  
Keyword(s):  
Immune Response ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Innate Immune Response ◽  
Suppressor Gene ◽  
Innate Immune ◽  
Immune Response Regulation

scholarly journals Kallikrein 12 Regulates Innate Resistance of Murine Macrophages against Mycobacterium bovis Infection by Modulating Autophagy and Apoptosis

Cells ◽  
2019 ◽  
Vol 8 (5) ◽  
pp. 415 ◽  
Author(s):  
Naveed Sabir ◽  
Tariq Hussain ◽  
Yi Liao ◽  
Jie Wang ◽  
Yinjuan Song ◽  
...  
Keyword(s):  
Immune Response ◽  
Mycobacterium Bovis ◽  
Serine Proteases ◽  
New Paradigm ◽  
Murine Macrophages ◽  
Immune Response Regulation ◽  
The Difference

Mycobacterium bovis (M. bovis) is a member of the Mycobacterium tuberculosis (Mtb) complex causing bovine tuberculosis (TB) and imposing a high zoonotic threat to human health. Kallikreins (KLKs) belong to a subgroup of secreted serine proteases. As their role is established in various physiological and pathological processes, it is likely that KLKs expression may mediate a host immune response against the M. bovis infection. In the current study, we report in vivo and in vitro upregulation of KLK12 in the M. bovis infection. To define the role of KLK12 in immune response regulation of murine macrophages, we produced KLK12 knockdown bone marrow derived macrophages (BMDMs) by using siRNA transfection. Interestingly, the knockdown of KLK12 resulted in a significant downregulation of autophagy and apoptosis in M. bovis infected BMDMs. Furthermore, we demonstrated that this KLK12 mediated regulation of autophagy and apoptosis involves mTOR/AMPK/TSC2 and BAX/Bcl-2/Cytochrome c/Caspase 3 pathways, respectively. Similarly, inflammatory cytokines IL-1β, IL-6, IL-12 and TNF-α were significantly downregulated in KLK12 knockdown macrophages but the difference in IL-10 and IFN-β expression was non-significant. Taken together, these findings suggest that upregulation of KLK12 in M. bovis infected murine macrophages plays a substantial role in the protective immune response regulation by modulating autophagy, apoptosis and pro-inflammatory pathways. To our knowledge, this is the first report on expression and the role of KLK12 in the M. bovis infection and the data may contribute to a new paradigm for diagnosis and treatment of bovine TB.

scholarly journals Features of immunoregulation in patients with pulmonary tuberculosis with blood eosinophilia

2018 ◽  
Vol 17 (3) ◽  
pp. 168-179
Author(s):  
O. I. Urazova ◽  
E. G. Churina ◽  
Yu. V. Kolobovnikova ◽  
V. V. Novitskiy ◽  
A. V. Karaulov ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Regulatory T Cells ◽  
Pulmonary Tuberculosis ◽  
Venous Blood ◽  
Enzyme Linked Immunosorbent Assay ◽  
Mononuclear Leukocytes ◽  
Blood Eosinophilia ◽  
Immune Response Regulation

The aimof the investigation was to determine the characteristics of the immune response regulation for pulmonary tuberculosis (TB) and to analyze the role of regulatory T cells in the immunopathogenesis of TB with eosinophilia in the blood, depending on the clinical form of the disease and sensitivity of Micobacterium tuberculosis to anti-TB drugs.Materials and methods.157 patients who were initially diagnosed with infiltrative and disseminated TB were examined. The material of the study was venous blood and culture of mononuclear leukocytes isolated from venous blood. The content of interleukin (IL) 4, IL-10 and transforming factor beta (TGFβ) in culture suspensions of mononuclear leukocytes in vitro and IL-5 in the blood was determined by enzyme-linked immunosorbent assay (ELISA) test. The expression of surface molecules CD4, CD20, CD25 and intracellular transcription factor Foxp3 by lymphocytes of the blood was evaluated by flow cytometry. The obtained results were analyzed by statistical methods.Results.It is shown that excessive generation of regulatory T cells in patients with TB is associated with eosinophilia of the blood and imbalance of immune response regulation mechanisms. In TB with eosinophilia, an increase in the number of Foxp3-positive regulatory T cells in the blood is combined with in vitro hypersecretion of anti-inflammatory cytokines TGFβ, IL-10, IL-4 and an increase in the content of CD20+ B lymphocytes and IL-5 in the blood. These changes are most pronounced in the disseminated form of TB in combination with drug resistance.Conclusion.Characteristics of immunoregulation at TB with blood eosinophilia are associated with activation of immunosuppression mechanisms and polarization of immune response towards Th2-dependent pathway.

scholarly journals Editorial: Role of Ribonucleases in Immune Response Regulation During Infection and Cancer

2020 ◽  
Vol 11 ◽  
Author(s):  
Ester Boix ◽  
Francesco Acquati ◽  
Demetres Leonidas ◽  
David Pulido
Keyword(s):  
Immune Response ◽  
Immune Response Regulation
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