scholarly journals Estramustine Phosphate Sodium

2020 ◽  
Author(s):  
Keyword(s):  
Estramustine Phosphate

Efficacy of estramustine phosphate according to risk classification of castration-resistant prostate cancer

2012 ◽  
Vol 29 (4) ◽  
pp. 2895-2900 ◽  
Author(s):  
Akinori Minato ◽  
Naohiro Fujimoto ◽  
Tatsuhiko Kubo ◽  
Shuji Harada ◽  
Soichiro Akasaka ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Risk Classification ◽  
Estramustine Phosphate ◽  
Castration Resistant Prostate Cancer ◽  
Castration Resistant

Effective and Safe Administration of Low-Dose Estramustine Phosphate for Castration-Resistant Prostate Cancer

2016 ◽  
Vol 14 (1) ◽  
pp. e9-e17 ◽  
Author(s):  
Takahiro Inoue ◽  
Keiji Ogura ◽  
Mutushi Kawakita ◽  
Hiromasa Tsukino ◽  
Shusuke Akamatsu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Low Dose ◽  
Estramustine Phosphate ◽  
Castration Resistant Prostate Cancer ◽  
Castration Resistant

Estramustine phosphate in prostate cancer

Urology ◽  
1984 ◽  
Vol 23 (6) ◽  
pp. 64-68 ◽  
Author(s):  
P.H. Smith ◽  
M. Robinson ◽  
B. Richards ◽  
S. Suciu ◽  
M. de Pauw ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Estramustine Phosphate

scholarly journals Estramustine Phosphate Inhibits TGF-β-Induced Mouse Macrophage Migration and Urokinase-Type Plasminogen Activator Production

2018 ◽  
Vol 2018 ◽  
pp. 1-10
Author(s):  
Sonja S. Mojsilovic ◽  
Slavko Mojsilovic ◽  
Suncica Bjelica ◽  
Juan F. Santibanez
Keyword(s):  
Cell Migration ◽  
Cell Motility ◽  
Plasminogen Activator ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Raw 264.7 ◽  
Estramustine Phosphate ◽  
Macrophage Cell ◽  
Type Plasminogen Activator ◽  
Urokinase Type Plasminogen Activator

Transforming growth factor-beta (TGF-β) has been demonstrated as a key regulator of immune responses including monocyte/macrophage functions. TGF-β regulates macrophage cell migration and polarization, as well as it is shown to modulate macrophage urokinase-type plasminogen activator (uPA) production, which also contributes to macrophage chemotaxis and migration toward damaged or inflamed tissues. Microtubule (MT) cytoskeleton dynamic plays a key role during the cell motility, and any interference on the MT network profoundly affects cell migration. In this study, by using estramustine phosphate (EP), which modifies MT stability, we analysed whether tubulin cytoskeleton contributes to TGF-β-induced macrophage cell migration and uPA expression. We found out that, in the murine macrophage cell line RAW 264.7, EP at noncytotoxic concentrations inhibited cell migration and uPA expression induced by TGF-β. Moreover, EP greatly reduced the capacity of TGF-β to trigger the phosphorylation and activation of its downstream Smad3 effector. Furthermore, Smad3 activation seems to be critical for the increased cell motility. Thus, our data suggest that EP, by interfering with MT dynamics, inhibits TGF-β-induced RAW 264.7 cell migration paralleled with reduction of uPA induction, in part by disabling Smad3 activation by TGF-β.

Estramustine Phosphate in the Treatment of Advanced Prostatic Cancer

1980 ◽  
Vol 52 (1) ◽  
pp. 29-33 ◽  
Author(s):  
S. KHOURY ◽  
F. RICHARD ◽  
F. FOURCADE ◽  
P. FRANTZ ◽  
J. P. CAPELLE
Keyword(s):  
Prostatic Cancer ◽  
Estramustine Phosphate ◽  
Advanced Prostatic Cancer

Estramustine Phosphate: Metabolic Aspects Related to Its Action in Prostatic Cancer

1978 ◽  
Vol 119 (2) ◽  
pp. 235-238 ◽  
Author(s):  
N. Kadohama ◽  
R.Y. Kirdani ◽  
G.P. Murphy ◽  
A.A. Sandberg
Keyword(s):  
Prostatic Cancer ◽  
Estramustine Phosphate

The hydrolysis of estramustine phosphate; in vitro studies

1983 ◽  
Vol 8 (4) ◽  
pp. 395-402 ◽  
Author(s):  
Per Olov Gunnarsson ◽  
Sven-Börje Andersson ◽  
Sven-Åke Johansson
Keyword(s):  
In Vitro Studies ◽  
Estramustine Phosphate ◽  
Hydrolysis Of
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