scholarly journals Neuromedin N

2020 ◽  
Author(s):  
Keyword(s):  
Neuromedin N

scholarly journals Lithium dramatically potentiates neurotensin/neuromedin N gene expression.

1988 ◽  
Vol 263 (28) ◽  
pp. 13983-13986
Author(s):  
P R Dobner ◽  
A S Tischler ◽  
Y C Lee ◽  
S R Bloom ◽  
S R Donahue
Keyword(s):  
Gene Expression ◽  
N Gene ◽  
Neuromedin N

Neurotensin and neuromedin N brain levels after fornix transection: evidence for an efficient neurotensin precursor processing in subicular neurons

1995 ◽  
Vol 702 (1-2) ◽  
pp. 279-283 ◽  
Author(s):  
Arnaud Nicot ◽  
Jean-Noel Bidard ◽  
Patrick Kitabgi ◽  
Anne-Marie Lhiaubet ◽  
Yoshinori Masuo ◽  
...  
Keyword(s):  
Precursor Processing ◽  
Brain Levels ◽  
Neuromedin N

Abstract 14088: Pro-neurotensin/neuromedin N is Associated With Incident Metabolic Syndrome

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Charles D Nicoli ◽  
April P Carson ◽  
Timothy B Plante ◽  
Leann Long ◽  
Leslie A McClure ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Glycemic Control ◽  
Racial Differences ◽  
Density Lipoprotein ◽  
Fatty Acid Uptake ◽  
Acid Uptake ◽  
High Systolic Blood Pressure ◽  
Neuromedin N

Introduction: The tridecapeptide neurotensin increases dietary fatty acid uptake and is implicated in insulin resistance in animal models and—through plasma levels of its stable precursor pro-neurotensin/neuromedin N (pro-NT/NMN)—with human diabetes mellitus, obesity, and cardiovascular disease. We evaluated the association of pro-NT/NMN with incident metabolic syndrome (MetS). Methods: This analysis included a subcohort of 2,770 Black and White participants without prevalent MetS at baseline (2003-2007) from the REasons for Geographic And Racial Differences in Stroke study who had fasting plasma pro-NT/NMN measured by immunoassay and completed a second assessment from 2013-2016. Incident MetS was defined as ≥3 harmonized criteria at follow-up: impaired glycemic control, high systolic blood pressure, high triglycerides, low high-density lipoprotein (HDL), and increased waist circumference. Four sequential weighted logistic regression models were fitted to incident MetS overall and for each criterion separately, incorporating demographic factors, metabolic risk factors, HOMA-IR, and diet scores. Results: Over mean 9.4 (standard deviation [SD] 1.0) years follow up, 564 participants developed MetS. Median [IQR] plasma pro-NT/NMN was 160 [118-218] pmol/L. In the overall group, higher log pro-NT/NMN was associated with incidence of lower HDL (odds ratio [OR] per SD pro-NT/NMN 1.16, 95% confidence interval [CI] 1.00-1.35) and impaired glycemic control (1.25, 95% CI 1.11-1.40), but not other MetS components. Each SD higher log pro-NT/NMN was associated with a 22% increased odds of incident MetS, adjusted for demographics (Table); this was not significant when controlling for HOMA-IR in all but the White subgroup (race p -interaction 0.05). No differences by sex were observed. Conclusions: Higher neurotensin likely augments insulin resistance to increase odds of incident metabolic syndrome through impaired glycemic control and lower HDL.

Posttranslational Processing of the Neurotensin/Neuromedin-N Precursor

1992 ◽  
Vol 668 (1 The Neurobiol) ◽  
pp. 1-16 ◽  
Author(s):  
ROBERT E. CARRAWAY ◽  
SANKAR P. MITRA ◽  
GLEN SPAULDING
Keyword(s):  
Posttranslational Processing ◽  
Neuromedin N
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