scholarly journals ETS Homologous Factor

2020 ◽  
Author(s):  
Keyword(s):  
Ets Homologous Factor

scholarly journals EHF suppresses cancer progression by inhibiting ETS1-mediated ZEB expression

Oncogenesis ◽  
2021 ◽  
Vol 10 (3) ◽  
Author(s):  
Kaname Sakamoto ◽  
Kaori Endo ◽  
Kei Sakamoto ◽  
Kou Kayamori ◽  
Shogo Ehata ◽  
...  
Keyword(s):  
Cancer Progression ◽  
Epithelial Mesenchymal Transition ◽  
Short Form ◽  
Dominant Negative ◽  
Mesenchymal Transition ◽  
Exon 1 ◽  
Ets Transcription Factor ◽  
Ets Homologous Factor ◽  
Form Variant

AbstractETS homologous factor (EHF) belongs to the epithelium-specific subfamily of the E26 transformation-specific (ETS) transcription factor family. Currently, little is known about EHF’s function in cancer. We previously reported that ETS1 induces expression of the ZEB family proteins ZEB1/δEF1 and ZEB2/SIP1, which are key regulators of the epithelial–mesenchymal transition (EMT), by activating the ZEB1 promoters. We have found that EHF gene produces two transcript variants, namely a long form variant that includes exon 1 (EHF-LF) and a short form variant that excludes exon 1 (EHF-SF). Only EHF-SF abrogates ETS1-mediated activation of the ZEB1 promoter by promoting degradation of ETS1 proteins, thereby inhibiting the EMT phenotypes of cancer cells. Most importantly, we identified a novel point mutation within the conserved ETS domain of EHF, and found that EHF mutations abolish its original function while causing the EHF protein to act as a potential dominant negative, thereby enhancing metastasis in vivo. Therefore, we suggest that EHF acts as an anti-EMT factor by inhibiting the expression of ZEBs, and that EHF mutations exacerbate cancer progression.

scholarly journals Ets homologous factor (EHF) has critical roles in epithelial dysfunction in airway disease

2017 ◽  
Vol 292 (26) ◽  
pp. 10938-10949 ◽  
Author(s):  
Sara L. Fossum ◽  
Michael J. Mutolo ◽  
Antonio Tugores ◽  
Sujana Ghosh ◽  
Scott H. Randell ◽  
...  
Keyword(s):  
Airway Disease ◽  
Epithelial Dysfunction ◽  
Ets Homologous Factor

scholarly journals Blockage of ETS homologous factor inhibits the proliferation and invasion of gastric cancer cells through the c-Met pathway

2020 ◽  
Vol 26 (47) ◽  
pp. 7497-7512
Author(s):  
Meng-Li Gu ◽  
Xin-Xin Zhou ◽  
Meng-Ting Ren ◽  
Ke-Da Shi ◽  
Mo-Sang Yu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Gastric Cancer Cells ◽  
Ets Homologous Factor ◽  
Proliferation And Invasion

scholarly journals Tumoral EHF predicts the efficacy of anti-PD1 therapy in pancreatic ductal adenocarcinoma

2019 ◽  
Vol 216 (3) ◽  
pp. 656-673 ◽  
Author(s):  
Jing Liu ◽  
Wenna Jiang ◽  
Kaili Zhao ◽  
Hongwei Wang ◽  
Tianxing Zhou ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Cd8 T Cells ◽  
Response Rate ◽  
Suppressor Cells ◽  
Ductal Adenocarcinoma ◽  
Myeloid Derived Suppressor Cells ◽  
Immune Microenvironment ◽  
Gm Csf ◽  
Ets Homologous Factor ◽  
Efficacy Prediction

Pancreatic ductal adenocarcinoma (PDAC) is a highly immune-suppressive tumor with a low response rate to single checkpoint blockade therapy. ETS homologous factor (EHF) is a tumor suppressor in PDAC. Here, we report a novel function of EHF in pancreatic cancer immune microenvironment editing and efficacy prediction for anti-PD1 therapy. Our findings support that the deficiency of tumoral EHF induced the accumulation of regulatory T (T reg) cells and myeloid-derived suppressor cells (MDSCs) and a decrease in the number of tumor-infiltrating CD8+ T cells. Mechanistically, EHF deficiency induced the conversion and expansion of T reg cells and MDSCs through inhibiting tumor TGFβ1 and GM-CSF secretion. EHF suppressed the transcription of TGFB1 and CSF2 by directly binding to their promoters. Mice bearing EHF overexpression tumors exhibited significantly better response to anti-PD1 therapy than those with control tumors. Our findings delineate the immunosuppressive mechanism of EHF deficiency in PDAC and highlight that EHF overexpression may improve PDAC checkpoint immunotherapy.

scholarly journals Ets homologous factor regulates pathways controlling response to injury in airway epithelial cells

2014 ◽  
Vol 42 (22) ◽  
pp. 13588-13598 ◽  
Author(s):  
Sara L. Fossum ◽  
Michael J. Mutolo ◽  
Rui Yang ◽  
Hong Dang ◽  
Wanda K. O'Neal ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Airway Epithelial Cells ◽  
Airway Epithelial ◽  
Ets Homologous Factor
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