scholarly journals Diagnostic Reagent

2020 ◽  
Author(s):  
Keyword(s):  
Diagnostic Reagent

Urinalysis

Nursing OSCEs ◽  
2012 ◽  
Author(s):  
Jane Lovegrove
Keyword(s):  
Chemical Analysis ◽  
Low Cost ◽  
Microscopic Investigation ◽  
Accurate Information ◽  
Clinical Settings ◽  
Acute Care Setting ◽  
Urethral Meatus ◽  
Naked Eye ◽  
Nurse Students ◽  
Diagnostic Reagent

Urinalysis simply means analysis of urine. It is an easily performed investigation that can detect a wide variety of abnormalities within a few minutes at low cost. Urinalysis is an investigation which all nurses should be competent to perform and is identified by the NMC (2007) as being an example of an essential skill nurse students should be competent to perform before entering their branch programme. Urinalysis may be performed in a wide variety of clinical settings. It should be performed on every patient entering the acute care setting. Additionally, the National Confidential Enquiry into Patient Outcome and Death (NCEPOD (2009), stresses the need for urinalysis to be performed on all emergency admissions to an acute hospital. It may also be performed in outpatient and general practice clinics, and community areas. To obtain the most accurate information from the test, students need to know how to obtain and assess a sample of urine and be aware of factors that may influence the reliability of the investigation. Urine may be tested in three different ways. ● Macroscopic urinalysis, ● Microscopic urinalysis, ● Chemical analysis. Macroscopic and chemical analysis are the investigations performed in the clinical setting which may be tested by OSCE. Microscopic investigation requires samples to be sent to a laboratory. Macroscopic analysis is the analysis of the urine by the naked eye. Chemical analysis may be performed by use of a plastic diagnostic reagent strip or ‘dipstick’ which contains small pads of chemicals which react to substances that may be found in urine. For purposes of testing urine at random, clients are asked to urinate into a clean but not sterile dry container with no precautions regarding contamination. In females in particular this may result in samples being contaminated by vaginal fluids, such as blood or mucus. Due to the risk of contamination a mid-stream specimen of urine may be required if an abnormality is found in a random sample. A mid-stream specimen requires cleaning of the external urethral meatus prior to urination, passing the first half of the bladder contents into the lavatory, and passing the second part of the urine flow into a sterile container.

Human recombinant LKM (P150 DB1) antigen is a sensitive and specific diagnostic reagent for differential diagnosis of chronic hepatitis

1989 ◽  
Vol 9 ◽  
pp. S59
Author(s):  
M. Manns ◽  
E.F. Johnson ◽  
K.J. Griffin ◽  
K.-H.Meyer zum Büschenfelde ◽  
E.M. Tan ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Chronic Hepatitis ◽  
Diagnostic Reagent

scholarly journals Gastric cancer indocyanine green lymph node navigation surgery: systematic review

2018 ◽  
Author(s):  
Beatrice Molteni ◽  
Paola Porsio ◽  
Sarah Molfino ◽  
Marie Sophie Alfano ◽  
Sara Benedicenti ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Systematic Review ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Indocyanine Green ◽  
Navigation Surgery ◽  
Diagnostic Reagent

Sentinel lymph node (LN) biopsy is a common practice to determinate if a lymphadenectomy is needed in various malignancies. Recent studies have investigated the possibilities to extend sentinel LN biopsy in gastric cancer. Indocyanine green (ICG) is a diagnostic reagent recently introduce in sentinel LN biopsy field. This review aims to determinate the feasibility to used ICG to detect sentinel LN in gastric cancer.

scholarly journals Use of immuno-dominant epitope derived from genotype 4 as a diagnostic reagent for detecting the antibodies against Hepatitis E Virus

2013 ◽  
Vol 10 (1) ◽  
pp. 131 ◽  
Author(s):  
Xiu Bing-shui ◽  
Feng Xiao-yan ◽  
He Jing ◽  
Chen Kun ◽  
Liu Jing ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Genotype 4 ◽  
Dominant Epitope ◽  
Diagnostic Reagent

scholarly journals Interactions of Paraoxonase-1 with Pharmacologically Relevant Carbamates

Molecules ◽  
2020 ◽  
Vol 25 (1) ◽  
pp. 211 ◽  
Author(s):  
Anita Bosak ◽  
Aljoša Bavec ◽  
Tilen Konte ◽  
Goran Šinko ◽  
Zrinka Kovarik ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Molecular Modelling ◽  
Active Site ◽  
Competitive Inhibition ◽  
Dissociation Constants ◽  
Paraoxonase 1 ◽  
Pon1 Activity ◽  
Non Covalent Interactions ◽  
Covalent Interactions ◽  
Diagnostic Reagent

Mammalian paraoxonase-1 hydrolyses a very broad spectrum of esters such as certain drugs and xenobiotics. The aim of this study was to determine whether carbamates influence the activity of recombinant PON1 (rePON1). Carbamates were selected having a variety of applications: bambuterol and physostigmine are drugs, carbofuran is used as a pesticide, while Ro 02-0683 is diagnostic reagent. All the selected carbamates reduced the arylesterase activity of rePON1 towards the substrate S-phenyl thioacetate (PTA). Inhibition dissociation constants (Ki), evaluated by both discontinuous and continuous inhibition measurements (progress curves), were similar and in the mM range. The rePON1 displayed almost the same values of Ki constants for Ro 02-0683 and physostigmine while, for carbofuran and bambuterol, the values were approximately ten times lower and two times higher, respectively. The affinity of rePON1 towards the tested carbamates was about 3–40 times lower than that of PTA. Molecular modelling of rePON1-carbamate complexes suggested non-covalent interactions with residues of the rePON1 active site that could lead to competitive inhibition of its arylesterase activity. In conclusion, carbamates can reduce the level of PON1 activity, which should be kept in mind, especially in medical conditions characterized by reduced PON1 levels.

Diagnostic reagent kits—embarras de richesse

1983 ◽  
Vol 43 (2) ◽  
pp. 99-101 ◽  
Author(s):  
Asbjørn Aakvaag ◽  
Goran Lindstedt ◽  
Arno Nyberg ◽  
Helena Holmberg ◽  
Jan Møller ◽  
...  
Keyword(s):  
Diagnostic Reagent
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