Laboratory Animal Genetic Monitoring Resource

2020 ◽  
Author(s):  
Keyword(s):  
Laboratory Animal ◽  
Genetic Monitoring

scholarly journals Genetic quality assurance and genetic monitoring of laboratory mice and rats: FELASA Working Group Report

2019 ◽  
Vol 54 (2) ◽  
pp. 135-148 ◽  
Author(s):  
Fernando Benavides ◽  
Thomas Rülicke ◽  
Jan-Bas Prins ◽  
James Bussell ◽  
Ferdinando Scavizzi ◽  
...  
Keyword(s):  
Quality Assurance ◽  
Working Group ◽  
Laboratory Animal ◽  
Inbred Strains ◽  
Genetic Monitoring ◽  
Laboratory Mice ◽  
Genetic Composition ◽  
Genetic Quality ◽  
Laboratory Rodents ◽  
Group Report

Genetic quality assurance (QA), including genetic monitoring (GeMo) of inbred strains and background characterization (BC) of genetically altered (GA) animal models, should be an essential component of any QA programme in laboratory animal facilities. Genetic quality control is as important for ensuring the validity of the animal model as health and microbiology monitoring are. It should be required that studies using laboratory rodents, mainly mice and rats, utilize genetically defined animals. This paper, presented by the FELASA Working Group on Genetic Quality Assurance and Genetic Monitoring of Laboratory Murines, describes the objectives of and available methods for genetic QA programmes in rodent facilities. The main goals of any genetic QA programme are: (a) to verify the authenticity and uniformity of inbred stains and substrains, thus ensuring a genetically reliable colony maintenance; (b) to detect possible genetic contamination; and (c) to precisely describe the genetic composition of GA lines. While this publication focuses mainly on mouse and rat genetic QA, the principles will apply to other rodent species some of which are briefly mentioned within the context of inbred and outbred stocks.

Laboratory Animal Research Centre (Larc) “A Specific Pathogen Free Rodent Facility” - Covid – 19 Pandemic Response Plan

2020 ◽  
Author(s):  
Muralitharan Shanmugakonar ◽  
Vijay Kanth Govindharajan ◽  
Kavitha Varadharajan ◽  
Hamda Al-Naemi
Keyword(s):  
Laboratory Animal ◽  
Animal Research ◽  
Research Centre ◽  
Functional Requirement ◽  
Specific Pathogen Free ◽  
Specific Pathogen ◽  
Response Plan ◽  
Pandemic Response ◽  
Operational Plan

Laboratory Animal Research Centre (LARC) has developed an early emergency operational plan for COVID-19 pandemic situation. Biosafety and biosecurity measures were planned and implemented ahead of time to check the functional requirement to prevent the infection. Identified necessary support for IT, transport, procurement, finance, admin and research to make the operations remotely and successfully.

Learning organizations and animal care programs in the absence of appropriate national legislation

2021 ◽  
pp. 002367722110192
Author(s):  
Lazara Martínez-Muñoz
Keyword(s):  
Latin American ◽  
Laboratory Animal ◽  
Management Education ◽  
Education Programs ◽  
Animal Science ◽  
Five Disciplines ◽  
Research Facilities ◽  
Animal Care ◽  
Latin American Countries ◽  
Working Method

The absence, in many nations, of appropriate and corresponding legislation for the protection of experimental animals as well as continual management education programs, significantly affects the inclusion and recognition of experimental results, worldwide. For more than a decade, researchers from Latin American countries have unsuccessfully struggled to get proper legislation. Until today, not many effective results have been seen. After reviewing previous literature and carefully analyzing the available methodologies and practical examples, this paper aims at redesigning the actions and strategies of the members of the research facilities to implement an effective laboratory animal care and use program, and permit the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC) accreditation, independent of national legislative network .This paper also suggests a domestic working method for the teamwork to assume international harmonized legislation, through the application of the Five Disciplines stated by Senge, as methodological process linked with laboratory animal science as scientific background.

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