scholarly journals Pancreatic Alpha Cell Adenoma

2020 ◽  
Author(s):  
Keyword(s):  
Alpha Cell ◽  
Cell Adenoma ◽  
Pancreatic Alpha Cell

Pancreatic Alpha-Cell Function and Identity in Human T2D

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 315-LB
Author(s):  
XIAOQING DAI ◽  
JOAN CAMUNAS SOLER ◽  
LINFORD BRIANT ◽  
ALIYA F. SPIGELMAN ◽  
YAN HANG ◽  
...  
Keyword(s):  
Cell Function ◽  
Alpha Cell ◽  
Pancreatic Alpha Cell ◽  
Alpha Cell Function

Postprandial Lipemia Modulates Pancreatic Alpha-Cell Function in the Prediction of Type 2 Diabetes Development: The CORDIOPREV Study

2020 ◽  
Vol 68 (5) ◽  
pp. 1266-1275
Author(s):  
Isabel Pozuelo-Sanchez ◽  
Alejandro Villasanta-Gonzalez ◽  
Juan Francisco Alcala-Diaz ◽  
Cristina Vals-Delgado ◽  
Ana Leon-Acuña ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cell Function ◽  
Postprandial Lipemia ◽  
Alpha Cell ◽  
Pancreatic Alpha Cell ◽  
Diabetes Development ◽  
Alpha Cell Function

On the Electrophysiological Component of Pancreatic Alpha-Cell Models

2021 ◽  
Author(s):  
Hugo E. Romero-Campos ◽  
Genevieve Dupont ◽  
Virginia Gonzalez-Velez
Keyword(s):  
Alpha Cell ◽  
Cell Models ◽  
Pancreatic Alpha Cell

Pancreatic alpha-cell function in trauma

JAMA ◽  
1974 ◽  
Vol 227 (7) ◽  
pp. 757-761 ◽  
Author(s):  
A. Lindsey
Keyword(s):  
Cell Function ◽  
Alpha Cell ◽  
Pancreatic Alpha Cell ◽  
Alpha Cell Function

Lack of Glucagon Response to Hypoglycemia in Diabetes: Evidence for an Intrinsic Pancreatic Alpha Cell Defect

Science ◽  
1973 ◽  
Vol 182 (4108) ◽  
pp. 171-173 ◽  
Author(s):  
J. E. Gerich ◽  
M. Langlois ◽  
C. Noacco ◽  
J. H. Karam ◽  
P. H. Forsham
Keyword(s):  
Alpha Cell ◽  
Pancreatic Alpha Cell ◽  
Cell Defect

ACROMEGALY: INSENSITIVITY OF THE PANCREATIC ALPHA CELL TO HYPERGLYCAEMIA

1978 ◽  
Vol 9 (6) ◽  
pp. 577-581 ◽  
Author(s):  
YUTAKA SEINO ◽  
TOMOHIKO TAMINATO ◽  
YASUO GOTO ◽  
YOSHIMICHI INOUE ◽  
SEIZO KADOWAKI ◽  
...  
Keyword(s):  
Alpha Cell ◽  
Pancreatic Alpha Cell

scholarly journals Pancreatic alpha cell tumors: Case report and review of the literature

Cancer ◽  
1980 ◽  
Vol 45 (10) ◽  
pp. 2675-2683 ◽  
Author(s):  
J. Lokich ◽  
N. Anderson ◽  
A. Rossini ◽  
W. Hadley ◽  
M. Federman ◽  
...  
Keyword(s):  
Case Report ◽  
Alpha Cell ◽  
Review Of The Literature ◽  
Pancreatic Alpha Cell

scholarly journals POU domain transcription factor brain 4 confers pancreatic alpha-cell-specific expression of the proglucagon gene through interaction with a novel proximal promoter G1 element.

1997 ◽  
Vol 17 (12) ◽  
pp. 7186-7194 ◽  
Author(s):  
M A Hussain ◽  
J Lee ◽  
C P Miller ◽  
J F Habener
Keyword(s):  
Gene Expression ◽  
Transcription Factor ◽  
Transcription Factors ◽  
Alpha Cell ◽  
Proximal Promoter ◽  
Major Constituent ◽  
Alpha Cells ◽  
Specific Expression ◽  
Pou Domain ◽  
Pancreatic Alpha Cell

The proglucagon gene is expressed in a highly restricted tissue-specific manner in the alpha cells of the pancreatic islet, the hypothalamus, and the small and large intestines. Proglucagon is processed to glucagon and glucagon-like peptides GLP-1 and -2. Glucagon is expressed in alpha cells and regulates glucose homeostasis. GLP-1 is implicated in the control of insulin secretion, food intake, and satiety signaling, and GLP-2 is implicated in regulating small-bowel growth. Cell-specific expression of the proglucagon gene is mediated by proteins that interact with the proximal G1 promoter element which contains several AT-rich domains with binding sites for homeodomain transcription factors. In an attempt to identify major homeodomain proteins involved in pancreatic alpha-cell-specific proglucagon expression, we found that the POU domain transcription factor brain 4 is abundantly expressed in proglucagon-producing islet cell lines and rat pancreatic islets. In the latter, brain 4 and glucagon immunoreactivity colocalize in the outer mantle of islets. Electrophoretic mobility shift assays with specific antisera identify brain 4 as a major constituent of nuclear proteins of glucagon-producing cells that bind to the G1 element of the proglucagon gene proximal promoter. Transcriptional transactivation experiments reveal that brain 4 is a major regulator of proglucagon gene expression by its interaction with the G1 element. The finding that a neuronal transcription factor is involved in glucagon gene transcription may explain the presence of proglucagon in certain areas of the brain as well as in pancreatic alpha cells. Further, this finding supports the idea that the neuronal properties of endodermis-derived endocrine pancreatic cells may find their basis in regulation of gene expression by neuronal transcription factors.

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