scholarly journals Malignant germ cell tumor of the corpus uteri

2020 ◽  
Author(s):  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Cell Tumor ◽  
Corpus Uteri ◽  
Malignant Germ Cell Tumor

Prognostic Impact of Lymphadenectomy in Different Stages of Malignant Germ Cell Tumor of the Ovary Based on Propensity Score Matching

2019 ◽  
Vol 21 (9) ◽  
pp. 652-661 ◽  
Author(s):  
Ying Chen ◽  
Yang Ning ◽  
Qinghua Zhang ◽  
Ying Xie
Keyword(s):  
Lymph Node ◽  
Propensity Score ◽  
Germ Cell ◽  
Propensity Score Matching ◽  
Germ Cell Tumor ◽  
Cell Tumor ◽  
Stage I ◽  
Prognostic Impact ◽  
Lymph Node Resection ◽  
Malignant Germ Cell Tumor

Background: Lymphadenectomy has been widely used in the treatment of malignant germ cell tumor of the ovary (OGCT), which is a kind of ovarian cancers occurred mostly in young women and adolescent girls. But the clinical decision mainly depends on the doctor’s experience without a well-defined guideline. This population-based study aimed to evaluate the prognostic impact of lymphadenectomy in different stages of malignant germ cell tumors of the ovary. Methods: Patients with known status of lymphadenectomy in different stages of OGCT were explored from the Surveillance, Epidemiology, and End Results (SEER) program database from 1973 to 2013. We used propensity score matching algorithm to reduce the selection bias between the two study groups. Survival curves, univariate and multivariate Cox proportional hazards model were applied to evaluate the prognostic impact of lymphadenectomy in different stages of OGCT. Results: We included 1,996 OGCT patients in the study, and 818 (41%) of them had lymph node resection. Compared to the LND- group, patients with lymph node resection tended to be at stage II and III, had larger tumor sizes and diagnosed as dysgerminoma. The influence of diagnosis ages, marital status and tumor grades were significantly decreased by applying the propensity score matching. Lymphadenectomy-positive (LND+) group demonstrated significantly worse survival than the lymphadenectomy-negative (LND-) group in later stages (stage III, overall, P=0.027, cancerspecific, P=0.006; stage IV, overall, P=0.034, cancer-specific, P=0.037). While, both the overall and cancer-specific survival showed no significant differences between LND+ and LND- in stage I (overall, P=0.411, cancer-specific, P=0.876) and stage II (overall, P=12, cancer-specific, P=0.061). Univariate (overall, HR=1.497, CI=1.010-2.217, P=0.044; cancer-specific, HR=1.524, CI=1.067- 2.404, P=0.050) and multivariate (overall, HR=1.580, CI=1.046-2.387, P=0.030; cancer-specific, HR=1.661, CI=1.027-2.686, P=0.039) Cox proportional model both verified the association between the lymph node resection and better survival in the whole cohort. Conclusion: Lymphadenectomy significantly increased the survival probability of OGCT patients in stage III and IV, but had no significant influence on early-stage patients (stage I and II), indicating lymphadenectomy should be performed in a stage-dependent manner in clinical utility.

Viable malignant germ cell tumor in the postchemotherapy retroperitoneal lymph node dissection specimen

Cancer ◽  
2006 ◽  
Vol 107 (7) ◽  
pp. 1503-1510 ◽  
Author(s):  
Philippe E. Spiess ◽  
Gordon A. Brown ◽  
Louis L. Pisters ◽  
Ping Liu ◽  
Shi-Ming Tu ◽  
...  
Keyword(s):  
Lymph Node ◽  
Germ Cell ◽  
Lymph Node Dissection ◽  
Germ Cell Tumor ◽  
Cell Tumor ◽  
Retroperitoneal Lymph Node Dissection ◽  
Node Dissection ◽  
Retroperitoneal Lymph Node ◽  
Malignant Germ Cell Tumor

Etoposide combination chemotherapy in refractory ovarian malignant germ cell tumor

1990 ◽  
Vol 39 (2) ◽  
pp. 123-126 ◽  
Author(s):  
L.C. Wong ◽  
R.J. Collins ◽  
H.Y.S. Ngan ◽  
H.K. Ma
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Combination Chemotherapy ◽  
Cell Tumor ◽  
Malignant Germ Cell Tumor

Treatment of intracranial nongerminomatous malignant germ cell tumor in children: the role of each treatment modality

1999 ◽  
Vol 15 (4) ◽  
pp. 185-191 ◽  
Author(s):  
Do-Hyun Nam ◽  
Byung-Kyu Cho ◽  
Hyung Jin Shin ◽  
Hyo Seop Ahn ◽  
Il Han Kim ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Treatment Modality ◽  
Cell Tumor ◽  
Malignant Germ Cell Tumor

scholarly journals Functioning malignant germ cell tumor of the ovary in a 41/2-year-old girl.case report

Cancer ◽  
1965 ◽  
Vol 18 (11) ◽  
pp. 1485-1488 ◽  
Author(s):  
Samuel Borushek ◽  
Isaac Berger ◽  
Charles Echt ◽  
Jay J. Gold
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Cell Tumor ◽  
Malignant Germ Cell Tumor

P1042 Oncologic and reproductive outcome after fertility-sparing management of malignant germ cell tumor of ovary

2009 ◽  
Vol 107 ◽  
pp. S705-S705
Author(s):  
K. Young-Tak ◽  
P. Jeong-Yeol ◽  
K. Dae-Yeon ◽  
K. Jong-Hyeok ◽  
K. Yong-Man ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Cell Tumor ◽  
Reproductive Outcome ◽  
Fertility Sparing ◽  
Malignant Germ Cell Tumor
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