scholarly journals Antidiarrheal Agent

2020 ◽  
Author(s):  
Keyword(s):  
Antidiarrheal Agent

scholarly journals Technological prospection of Diminazene Aceturate, an Angiotensin II Converting Enzyme activator, in front of diarrheic disorders

2020 ◽  
Vol 9 (12) ◽  
pp. e1691210755
Author(s):  
Luan Kelves Miranda de Souza ◽  
Kerolayne de Melo Nogueira ◽  
Jand Venes Rolim Medeiros
Keyword(s):  
Gastrointestinal Disease ◽  
Biological Activities ◽  
Fluid Replacement ◽  
Special Focus ◽  
Diminazene Aceturate ◽  
Oral Rehydration ◽  
International Patent ◽  
Rehydration Solution ◽  
Antidiarrheal Agent ◽  
Patent Filing

Diarrhea, which is a gastrointestinal disease, has as its main characteristic the rapid passage of gastric contents through the intestine, which leads to the loss of water and electrolytes and consequent dehydration. The most common fluid replacement is the use of oral rehydration solution (ORS) together with the use of the drug loperamide. However, the use of this medication can cause severe bacteremia followed by sepsis and even death. Currently, there is no effective pharmacological treatment for diarrhea, therefore, it is noted the importance of seeking new therapeutic targets for the treatment of this disease. Thus, the aim of the present study was to conduct a research on the biological activities already described for Diminazene Aceturate with a special focus on antidiarrheal agents. For this, a survey was carried out, through patent filing searches, in the USPTO, EPO, WIPO and INPI databases, using keywords and Boolean operators. Thus, it was found in the international patent databases the number of documents referring to the use of Diminazene Aceturate in several areas, mainly in the pharmaceutical industry, but with a relatively low number of documents regarding the description of possible antidiarrheal action of the compound under study , which reinforces the innovative character of research involving the use of Diminazene Aceturate as an antidiarrheal agent.

scholarly journals Loperamide Induced Life Threatening Ventricular Arrhythmia

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
Ankit Upadhyay ◽  
Vijaykumar Bodar ◽  
Mohammad Malekzadegan ◽  
Sharanjit Singh ◽  
William Frumkin ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Ventricular Arrhythmias ◽  
Cardiac Toxicity ◽  
Drug Abusers ◽  
Qtc Interval ◽  
Over The Counter ◽  
Life Threatening ◽  
Irritable Bowel ◽  
Antidiarrheal Agent ◽  
Congenital Long Qt Syndrome

Loperamide is over-the-counter antidiarrheal agent acting on peripherally locatedμopioid receptors. It is gaining popularity among drug abusers as opioid substitute. We report a case of a 46-year-old male that was presented after cardiac arrest. After ruling out ischemia, cardiomyopathy, pulmonary embolism, central nervous system pathology, sepsis, and other drug toxicity, we found out that patient was using around 100 mg of Loperamide to control his chronic diarrhea presumably because of irritable bowel syndrome for last five years and consumed up to 200 mg of Loperamide daily for last two days before the cardiac arrest. We hypothesize that the patient’s QTc prolongation and subsequent cardiac arrest are due to Loperamide toxicity. Patient experienced gradual resolution of tachyarrhythmia and gradual decrease in QTc interval during hospitalization which supports the evidence of causal relationship between Loperamide overdose and potentially fatal arrhythmias. It also provided the clue that patient may have congenital long QT syndrome which was unmasked by Loperamide causing ventricular arrhythmias. This case adds one more pearl in the literature to support that Loperamide overdose related cardiac toxicity does exist and it raises concerns over Loperamide abuse in the community.

scholarly journals Potent Inhibition of hERG Channels by the Over-the-Counter Antidiarrheal Agent Loperamide

2016 ◽  
Vol 2 (7) ◽  
pp. 784-789 ◽  
Author(s):  
Michael G. Klein ◽  
Mark C.P. Haigney ◽  
Philip S. Mehler ◽  
Naheed Fatima ◽  
Thomas P. Flagg ◽  
...  
Keyword(s):  
Over The Counter ◽  
Potent Inhibition ◽  
Herg Channels ◽  
Antidiarrheal Agent

scholarly journals Evaluation of BW942C, a novel antidiarrheal agent, against enterotoxins of Escherichia coli and Vibrio cholerae.

1985 ◽  
Vol 48 (3) ◽  
pp. 754-758 ◽  
Author(s):  
D R Morgan ◽  
J Sellin ◽  
L Gutierrez ◽  
H L DuPont ◽  
L V Wood
Keyword(s):  
Escherichia Coli ◽  
Vibrio Cholerae ◽  
Antidiarrheal Agent

Antidiarrheal Agent Poisoning in a Child

JAMA ◽  
1965 ◽  
Vol 192 (10) ◽  
pp. 920 ◽  
Author(s):  
John P. Canby
Keyword(s):  
Antidiarrheal Agent

scholarly journals Efficacy of veterinary antidiarrheal agent and antinflatulent against diarrhea of dogs

2009 ◽  
Vol 62 (10) ◽  
pp. 789-795
Author(s):  
Aya MATSUU ◽  
Yojiro SHIMADA ◽  
Eiji OKUDA ◽  
Masako HOSHI ◽  
Yuka NAKAMURA ◽  
...  
Keyword(s):  
Antidiarrheal Agent

scholarly journals Loperamide: A New Antidiarrheal Agent in the Treatment of Chronic Diarrhea

1976 ◽  
Vol 70 (6) ◽  
pp. 1026-1029 ◽  
Author(s):  
John T. Galambos ◽  
Theodore Hersh ◽  
Spalding Schroder ◽  
Julius Wenger
Keyword(s):  
Chronic Diarrhea ◽  
Antidiarrheal Agent

Effect of a novel antidiarrheal agent on ion transport across the rat jejunum and colon

1998 ◽  
Vol 114 ◽  
pp. A374
Author(s):  
B. Greenwood-Van Meerveld ◽  
K.R. Tyler ◽  
K. Venkova ◽  
M. Robinson ◽  
T. Kuge ◽  
...  
Keyword(s):  
Ion Transport ◽  
Rat Jejunum ◽  
Antidiarrheal Agent
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