scholarly journals Merkel Cell Carcinoma Pathologic Regional Lymph Nodes TNM Finding v8

2020 ◽  
Author(s):  
Keyword(s):  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Merkel Cell ◽  
Regional Lymph Nodes

scholarly journals A Review of Radiotherapy for Merkel Cell Carcinoma of the Head and Neck

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Justin Lee ◽  
Ian Poon ◽  
Judith Balogh ◽  
May Tsao ◽  
Elizabeth Barnes
Keyword(s):  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Merkel Cell Carcinoma ◽  
Adjuvant Radiotherapy ◽  
Primary Tumour ◽  
Critical Role ◽  
Lymph Node Biopsy ◽  
Merkel Cell ◽  
Regional Lymph Nodes

Merkel cell carcinoma of the head and neck (MCCHN) presents a clinical challenge due to its aggressive natural history, unpredictable lymphatic drainage, and high degree of treatment related morbidity. Histological examination of the regional lymph nodes is very important in determining the optimal treatment and is usually achieved by sentinel lymph node biopsy. Radiotherapy plays a critical role in the treatment of most patients with MCCHN. Surgery with adjuvant radiotherapy to the primary tumour site is associated with high local control rates. If lymph nodes are clinically or microscopically positive, adjuvant radiotherapy is indicated to decrease the risk of regional recurrence. The majority of locoregional recurrences occur at the edge or just outside of the radiation field, reflecting both the inherent radiosensitivity of MCC and the importance of relatively large volumes to include “in-transit” dermal lymphatic pathways. When surgical excision of the primary or nodal disease is not feasible, primary radiotherapy alone should be considered as a potentially curative modality and confers good loco-regional control. Concurrent chemoradiotherapy is well tolerated and may further improve outcomes.

Lymph Nodal Merkel Cell Carcinoma; Primary or Metastatic Disease? A Clinical Case

2002 ◽  
Vol 88 (5) ◽  
pp. 424-426 ◽  
Author(s):  
Giuseppe Fotia ◽  
Roberto Barni ◽  
Cristiana Bellan ◽  
Alessandro Neri
Keyword(s):  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Pulmonary Metastases ◽  
Histopathological Examination ◽  
Palliative Radiotherapy ◽  
Merkel Cell ◽  
Neoplastic Tissue ◽  
Regional Lymph Nodes

We report a case of Merkel cell carcinoma (MCC) presenting in the lymph nodes in the absence of a primary cutaneous site. The MCC was treated by palliative radiotherapy, which controlled the disease locally. Eight months after diagnosis a mass appeared on the ipsilateral knee; histopathological examination of this lesion confirmed the diagnosis of MCC. The patient died two months later due to the development of pulmonary metastases. Interestingly, the neoplastic tissue was confined to the regional lymph nodes for several months before the primary site appeared. Primary lymph nodal MCC is rare and the diagnosis is difficult. In our opinion the only way to make a diagnosis of primary lymph nodal MCC is by appropriate clinical follow-up.

scholarly journals Immunohistochemical analysis of sentinel lymph nodes from patients with Merkel cell carcinoma

Cancer ◽  
2001 ◽  
Vol 92 (6) ◽  
pp. 1650-1655 ◽  
Author(s):  
Peter J. Allen ◽  
Klaus Busam ◽  
Arnold D. K. Hill ◽  
Alexander Stojadinovic ◽  
Daniel G. Coit
Keyword(s):  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Immunohistochemical Analysis ◽  
Sentinel Lymph Nodes ◽  
Merkel Cell
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