Stereotactic Implantation

2020 ◽  
Author(s):  
Keyword(s):  
Stereotactic Implantation

scholarly journals Stereotactic system for accurately targeting deep brain structures in awake head-fixed mice

2019 ◽  
Vol 122 (3) ◽  
pp. 975-983 ◽  
Author(s):  
Yonatan Katz ◽  
Michael Sokoletsky ◽  
Ilan Lampl
Keyword(s):  
Brain Structures ◽  
Nucleus Basalis ◽  
Intracellular Recordings ◽  
Head Fixation ◽  
Stereotactic System ◽  
Stereotactic Implantation ◽  
Mammillothalamic Tract ◽  
And Behavior ◽  
Recording Electrodes ◽  
Deep Brain

Deep brain nuclei, such as the amygdala, nucleus basalis, and locus coeruleus, play a crucial role in cognition and behavior. Nonetheless, acutely recording electrical activity from these structures in head-fixed awake rodents has been very challenging due to the fact that head-fixed preparations are not designed for stereotactic accuracy. We overcome this issue by designing the DeepTarget, a system for stereotactic head fixation and recording, which allows for accurately directing recording electrodes or other probes into any desired location in the brain. We then validated it by performing intracellular recordings from optogenetically tagged amygdalar neurons followed by histological reconstruction, which revealed that it is accurate and precise to within ~100 μm. Moreover, in another group of mice we were able to target both the mammillothalamic tract and subthalamic nucleus. This approach can be adapted to any type of extracellular electrode, fiber optic, or other probe in cases where high accuracy is needed in awake, head-fixed rodents. NEW & NOTEWORTHY Accurate targeting of recording electrodes in awake head-restrained rodents is currently beyond our reach. We developed a device for stereotactic implantation of a custom head bar and a recording system that together allow the accurate and precise targeting of any brain structure, including deep and small nuclei. We demonstrated this by performing histology and intracellular recordings in the amygdala of awake mice. The system enables the targeting of any probe to any location in the awake brain.

Accuracy and Safety of Customized Stereotactic Fixtures for Stereoelectroencephalography in Pediatric Patients

2020 ◽  
pp. 1-8
Author(s):  
Constantin Pistol ◽  
Andrei Daneasa ◽  
Jean Ciurea ◽  
Alin Rasina ◽  
Andrei Barborica ◽  
...  
Keyword(s):  
Focal Epilepsy ◽  
Perioperative Complications ◽  
Intractable Epilepsy ◽  
Target Point ◽  
Seizure Freedom ◽  
Epileptogenic Zone ◽  
Localization Error ◽  
Temporal Area ◽  
Lateral Entry ◽  
Stereotactic Implantation

Stereoelectroencephalography (SEEG) in children with intractable epilepsy presents particular challenges. Their thin and partially ossified cranium, specifically in the temporal area, is prone to fracture while attaching stereotactic systems to the head or stabilizing the head in robot’s field of action. Postponing SEEG in this special population of patients can have serious consequences, reducing their chances of becoming seizure-free and impacting their social and cognitive development. This study demonstrates the safety and accuracy offered by a frameless personalized 3D printed stereotactic implantation system for SEEG investigations in children under 4 years of age. SEEG was carried out in a 3-year-old patient with drug-resistant focal epilepsy, based on a right temporal-perisylvian epileptogenic zone hypothesis. Fifteen intracerebral electrodes were placed using a StarFix patient-customized stereotactic fixture. The median lateral entry point localization error of the electrodes was 0.90 mm, median lateral target point localization error was 1.86 mm, median target depth error was 0.83 mm, and median target point localization error was 1.96 mm. There were no perioperative complications. SEEG data led to a tailored right temporal-insular-opercular resection, with resulting seizure freedom (Engel IA). In conclusion, patient-customized stereotactic fixtures are a safe and accurate option for SEEG exploration in young children.

Drug Targeting into the Central Nervous System by Stereotactic Implantation of Biodegradable Microspheres

Neurosurgery ◽  
1994 ◽  
Vol 34 (6) ◽  
pp. 1058-1064 ◽  
Author(s):  
Philippe Menei ◽  
Jean-Pierre Benoit ◽  
Michelle Boisdron-Celle ◽  
Dominique Fournier ◽  
Philippe Mercier ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Drug Targeting ◽  
Biodegradable Microspheres ◽  
The Central Nervous System ◽  
Stereotactic Implantation

Deep Brain Stimulation/Stereotaxic Surgery

2018 ◽  
Author(s):  
Sandra Machado
Keyword(s):  
Deep Brain Stimulation ◽  
Postoperative Complications ◽  
Essential Tremor ◽  
Brain Stimulation ◽  
Movement Disorders ◽  
Pulse Generator ◽  
Stereotactic Implantation ◽  
Two Stages ◽  
Effective Use ◽  
Deep Brain

Deep brain stimulation (DBS) is now a widely accepted treatment option for patients with movement disorders such as parkinsonism and essential tremor. DBS surgery presents challenges to the anesthesiologist as often these patients are required to be awake for accurate placement of the stimulators. Additionally, patients with movement disorders often have comorbidities that increase their risk of perioperative and postoperative complications. DBS surgery is often divided into two stages (1) stereotactic implantation of the DBS leads and (2) internalization of the pulse generator, with each of these stages stage having distinct anesthesia demands. Ongoing studies are exploring other indications for the effective use of DBS surgery.

Stereotaxic Implantation for Small Animals: An “Eyelet” Technique

1971 ◽  
Vol 33 (3_suppl) ◽  
pp. 1223-1226
Author(s):  
Peter O. Peretti ◽  
Laura B. Helwig
Keyword(s):  
Small Animals ◽  
Electrode Implantation ◽  
The Wire ◽  
Stereotactic Implantation

Frequently used methods of implanting electrodes in small animals include the use of small screws to anchor the unit in place, as well as the “wire-bridge” technique. Both of these methods had been used by present investigators and have been found useful. However, a number of animals were found unsatisfactory due to various problems. All of these problems led to the development of the “eyelet” technique of electrode implantation which provided their solutions. The technique and advantages of the stereotactic implantation are described.

Drug Targeting into the Central Nervous System by Stereotactic Implantation of Biodegradable Microspheres

Neurosurgery ◽  
1994 ◽  
Vol 34 (6) ◽  
pp. 1058-1064 ◽  
Author(s):  
Philippe Menei ◽  
Jean-Pierre Benoit ◽  
Michelle Boisdron-Celle ◽  
Dominique Fournier ◽  
Philippe Mercier ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Drug Targeting ◽  
Biodegradable Microspheres ◽  
The Central Nervous System ◽  
Stereotactic Implantation
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