Pheniramine Maleate

2020 ◽  
Author(s):  
Keyword(s):  
2021 ◽  
Vol 30 (2) ◽  
pp. 1-8
Author(s):  
Ahmad O. Rifai ◽  
Abeer M. Abd El-Aziz ◽  
Hany I. Kenawy

Background: Pseudomonas aeruginosa has developed different mechanisms of resistance against antibiotics and became one of the most life-threatening pathogens. Fighting against its virulence Factors are an alternative therapeutic target. Objective: This study was directed towards the investigation of anti-quorum sensing activity and inhibitory action on virulence factors of different agents including antibacterial agents to which Pseudomonas aeruginosa isolates are resistant and non-antibacterial agents. Methodology: Anti-quorum sensing activity of ceftriaxone, ceftazidime (CAZ), cefepime (FEP), vancomycin (VA), paracetamol (PA), and pheniramine maleate (PHE) investigated as well as their ability to reduce other virulence factors including protease, hemolysin, and pyocyanin production. Results: This study showed that 3rd and 4th generations cephalosporins could be used as anti-quorum sensing agents effectively in the treatment of Pseudomonas aeruginosa infections, however, vancomycin, paracetamol, and pheniramine maleate had no effect on inhibiting the studied virulence factors. Conclusion: From our study we conclude that although cephalosporins at the used concentrations did not show anti-pseudomonal activity they were effective as anti virulent agents that could be utilized in therapeutically in controlling Pseudomonas aeruginosa infections.


2012 ◽  
Vol 26 (4) ◽  
pp. 559-565 ◽  
Author(s):  
Serdar Bayrak ◽  
Ismail Yurekli ◽  
Orhan Gokalp ◽  
Muge Kiray ◽  
Mehmet Senel Bademci ◽  
...  

1975 ◽  
Vol 84 (2) ◽  
pp. 218-222
Author(s):  
J. W. Herndon ◽  
O. Haug ◽  
M. J. Horowitz ◽  
T. E. Lynes

Ru-Vert®, a combination product, containing in each tablet, 25 mg of pentylenetetrazol, 12.5 mg of pheniramine maleate, and 50 mg of nicotinic acid, was evaluated in the treatment of seventeen patients with benign paroxysmal positional vertigo. The study was double-blind with crossover. Ru-Vert® at a dosage of two tablets t.i.d. was found to reduce significantly the nystagmus and the vertigo induced by Hallpike maneuvers in these patients.


1999 ◽  
Vol 40 (6) ◽  
pp. 338-338 ◽  
Author(s):  
Gianluca Parente ◽  
Massimilano Pazzaglia ◽  
Colombina Vincenzi ◽  
Antonella Tosti

2016 ◽  
Vol 32 (3) ◽  
Author(s):  
OZGUR OZMEN ◽  
DUYGU KARA ◽  
EMINE UZLAS KARAMAN ◽  
FATMA KARAKOC ◽  
MUHAMMET AHMET KARAKAYA ◽  
...  
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