scholarly journals Neonatal Hyperglycemia

2020 ◽  
Author(s):  
Keyword(s):  
Neonatal Hyperglycemia

Neonatal Hyperglycemia

1999 ◽  
Vol 20 (7) ◽  
pp. e16-e24 ◽  
Author(s):  
Anusha H. Hemachandra ◽  
Richard M. Cowett
Keyword(s):  
Neonatal Hyperglycemia

scholarly journals Duplication 6q24: More Than Just Diabetes

2020 ◽  
Vol 4 (5) ◽  
Author(s):  
Rachel H Gore ◽  
Maria Eleni Nikita ◽  
Paula G Newton ◽  
Rebecca G Carter ◽  
Jeanine Reyes-Bautista ◽  
...  
Keyword(s):  
Chromosomal Abnormalities ◽  
Uniparental Disomy ◽  
Clinical Importance ◽  
Neonatal Diabetes ◽  
Increased Risk ◽  
Chromosome 6Q24 ◽  
History Of ◽  
Transient Neonatal Diabetes ◽  
Neonatal Hyperglycemia ◽  
Methylation Patterns

Abstract Chromosome 6q24-related transient neonatal diabetes mellitus is characterized by intrauterine growth restriction and low birth weight, with neonatal hyperglycemia resolving by 18 months and an increased risk for type 2 diabetes in adulthood. Molecularly, it is caused by overexpression of the 6q24 imprinted chromosomal region due to a duplication, uniparental disomy, or abnormal methylation. Conventional testing for this condition analyzes methylation patterns at the 6q24 locus but does not evaluate for the presence of other surrounding chromosomal abnormalities. We report a female with a history of neonatal hyperglycemia due to a paternally inherited duplication at chromosomal location 6q24. She subsequently presented to the pediatric genetics clinic at 15 months of age with developmental delay and abnormal balance. Microarray analysis identified a larger 14 Mb chromosomal duplication from 6q24 to 6q25.2, consistent with a diagnosis of duplication 6q syndrome. This case highlights the clinical importance of pursuing further genetic evaluation in patients diagnosed with chromosome 6q24-related neonatal hyperglycemia via targeted methylation-specific multiplex ligation-dependent probe amplification analysis identifying a duplication in this region. Early identification and intervention can improve developmental outcomes for patients with larger chromosome 6q duplications.

Neonatal hyperglycemia in a preterm infant managed with a subcutaneous insulin pump

2020 ◽  
Vol 77 (10) ◽  
pp. 739-744
Author(s):  
Julia D Muzzy Williamson ◽  
Brenda Thurlow ◽  
Mohamed W Mohamed ◽  
Dacotah Yokom ◽  
Luis Casas
Keyword(s):  
Blood Glucose ◽  
Preterm Infant ◽  
Glucose Concentration ◽  
Insulin Pump ◽  
Blood Glucose Concentration ◽  
Glucose Monitoring ◽  
Regular Insulin ◽  
Central Line ◽  
Subcutaneous Insulin ◽  
Neonatal Hyperglycemia

Abstract Purpose Successful use of a subcutaneous insulin pump to administer regular insulin to a preterm infant with neonatal hyperglycemia is described. Summary A 520-g female infant born at 23 weeks’ gestational age via caesarian section was noted to have elevated blood glucose concentrations ranging up to 180 mg/dL (in SI units, 10 mmol/L) on day of life (DOL) 3 and peaking on DOL 9 at 250 mg/dL (13.9 mmol/L) despite conservative glucose infusion rates. Continuous infusion of regular insulin was begun on DOL 8 and continued through DOL 44, with an average insulin infusion rate of 0.08 units/kg/h. The patient experienced blood glucose concentration lability due to multiple factors, resulting in the need for frequent and routine blood glucose concentration monitoring to minimize hypoglycemia events. On DOL 44, a subcutaneous insulin pump was placed and used to provide diluted regular insulin (25 units/mL). After 1 week, the patient’s blood glucose concentration normalized, which led to a reduction in the frequency of glucose monitoring. After 3 weeks, insulin pump use was discontinued. The patient remained euglycemic thereafter. Conclusion The use of an insulin pump resulted in decreased blood glucose checks, discontinuation of central line access, and overall better patient care.

scholarly journals Neonatal hyperglycemia and retinopathy of prematurity

2020 ◽  
Vol 76 (4) ◽  
pp. 480-481
Author(s):  
Vishal Vishnu Tewari ◽  
Subhash Chandra Shaw ◽  
G. Shridhar
Keyword(s):  
Retinopathy Of Prematurity ◽  
Neonatal Hyperglycemia

Neonatal hyperglycemia and chromosome deletion (46,XX,Dq-)

1976 ◽  
Vol 88 (6) ◽  
pp. 989-990 ◽  
Author(s):  
Jaakko Leisti ◽  
Kari Raivio ◽  
Kai Krohn
Keyword(s):  
Chromosome Deletion ◽  
Neonatal Hyperglycemia

scholarly journals Neonatal hyperglycemia alters the neurochemical profile, dendritic arborization and gene expression in the developing rat hippocampus

2018 ◽  
Vol 31 (5) ◽  
pp. e3910 ◽  
Author(s):  
Raghavendra Rao ◽  
Motaz Nashawaty ◽  
Saher Fatima ◽  
Kathleen Ennis ◽  
Ivan Tkac
Keyword(s):  
Gene Expression ◽  
Dendritic Arborization ◽  
Rat Hippocampus ◽  
Neurochemical Profile ◽  
Neonatal Hyperglycemia ◽  
Developing Rat

Letters to the Editor

PEDIATRICS ◽  
1967 ◽  
Vol 40 (1) ◽  
pp. 137-137
Author(s):  
J. GEEFHUYSEN
Keyword(s):  
Breast Milk ◽  
Letters To The Editor ◽  
Oral Fluids ◽  
Expressed Breast Milk ◽  
Neonatal Hyperglycemia

Thank you for forwarding the letter relating to a further case of temporary idiopathic neonatal hyperglycemia published by W. L. Burland. I apologize for overlooking Dr. Burland's port of a case of temporary idiopathic neonatal hyperglycemia, which brings the total to date up to 18. The infant described by me was rehydrated intravenously within 24 hours and thereafter was maintained on oral fluids of 360 ml expressed breast milk and 120 ml water per 24 hours. The infant gained weight normally and did not become dehydrated on this regime. Therefore, in this case no insulin appeared necessary.

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