scholarly journals Refractory Malignant Head and Neck Neoplasm

2020 ◽  
Author(s):  
Keyword(s):  
Head And Neck ◽  
Head And Neck Neoplasm

scholarly journals Epidemiology and Outcomes of Nasopharyngeal Carcinoma

2021 ◽  
Author(s):  
Gamal Abdul Hamid
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Head And Neck ◽  
Radiation Treatment ◽  
Survival Rates ◽  
Intracavitary Brachytherapy ◽  
Head And Neck Neoplasm ◽  
Great Good ◽  
Intensity Modulated ◽  
Southern Chinese ◽  
Epstein Barr

Nasopharyngeal carcinoma (NPC) is a rare head and neck neoplasm worldwide. It is common among the southern Chinese with significant geographical variation with the highest incidence being in Southeast Asia up to 6.4/100,000 males and 2.4/100,000 females in these regions and the Epstein Barr virus (EBV) is associated closely with NPC. This disease has peculiarities in its etiopathogenesis, presentation, risk of nodal and distant metastasis, response to therapy and overall survival (OS) outcomes that stand out as compared to other head and neck cancer subsites. NPC is mainly treated by RT and is profoundly radiosensitive and radiotherapy treatment is the spine of treatment for all stages of NPC without far off metastases. Many advances in RT techniques and schedules are attempted to improve outcomes of the disease starting from intracavitary brachytherapy, intensity modulated RT to simultaneous modulated accelerated RT, all showing some promise with most significant benefit seen with addition of chemotherapy, especially in intermediate (Stage II) and advanced (Stage III, IVA, IVB) cases. At a time when modern radiation treatment like intensity-modulated radiotherapy (IMRT) are accomplishing great good local control, distant metastases are getting to be the transcendent design of treatment failure, particularly in patients with locally progressed illness. There are numerous results from clinical trials looking at combined radiation treatment (RT) and chemotherapy for NPC. Survival rates significantly differ between NPC patients according to stages of disease.

scholarly journals Profile of parotid tumors visiting tertiary health care facility in North India

2020 ◽  
Vol 6 (5) ◽  
pp. 835
Author(s):  
Manish Munjal ◽  
Nitika Tuli ◽  
Porshia Rishi ◽  
Harjinder Singh ◽  
Shivam Talwar ◽  
...  
Keyword(s):  
Facial Nerve ◽  
Head And Neck ◽  
Head And Neck Neoplasms ◽  
Tertiary Care ◽  
Care Facility ◽  
Malignant Neoplasms ◽  
Head And Neck Neoplasm ◽  
Anatomical Landmarks ◽  
Parotid Tumors ◽  
Parotid Surgery

<p class="abstract"><strong>Background:</strong> Neoplastic lesions of head and neck presenting in a tertiary care facility were analyzed. This study is proposed to examine the epidemiological pattern of parotid tumors, histopathology correlations and relation of facial nerve with the parotid tumors.</p><p class="abstract"><strong>Methods:</strong> This is a retrospective study of patients with head and neck neoplasms who presented to the ENT tumour clinic of Dayanand Medical College and Hospital over a period of 2 years i.e., from January 2018 to December 2019. Patients’ demographic profile, histopathological reports and pre-operative fine needle aspiration cytology reports were studied.  </p><p class="abstract"><strong>Results:</strong> Total number of cases of head and neck neoplasms were 273 over a period of 2 years. Parotid tumours constituted 9.1% of the total head and neck neoplasm. Predominant age group in case of benign parotid tumors was 40-50 years, whereas in case of malignant neoplasms was 50-60 years. Posterior belly of digastric along with tragal pointer are the most consistent and reliable landmarks for Identification of facial nerve.</p><p><strong>Conclusions:</strong> Identification of trunk of facial nerve using anatomical landmarks is the keystone for parotid surgery. Posterior belly of digastric along with tragal pointer are the most consistent and reliable landmarks for Identification of facial nerve.  </p>

Safe dose reduction of steroid pre-medication for docetaxel in head and neck neoplasm treatment

2015 ◽  
Vol 136 (2) ◽  
pp. 177-180 ◽  
Author(s):  
Nan-Xiang Chen ◽  
Fei-Fan Zhao ◽  
Fang Yan ◽  
Xin-Xin Zhang
Keyword(s):  
Head And Neck ◽  
Dose Reduction ◽  
Head And Neck Neoplasm ◽  
Safe Dose

Human papillomavirus and p53 oncoprotein in verrucous carcinoma of the larynx

1996 ◽  
Vol 110 (8) ◽  
pp. 742-747 ◽  
Author(s):  
Manuel López-Amado ◽  
Tomás García-Caballero ◽  
Ascensión Lozano-Ramírez ◽  
Torcuato Labella-Caballero
Keyword(s):  
Human Papillomavirus ◽  
Head And Neck ◽  
Verrucous Carcinoma ◽  
Head And Neck Neoplasm ◽  
Tissue Samples ◽  
Tissue Sections ◽  
Formalin Fixed Paraffin ◽  
Carcinoma Of The Larynx ◽  
Formalin Fixed Paraffin Embedded ◽  
Positive Immunoreactivity

AbstractThe incidence of p53 antigen and human papillomavirus (HPV) expression in archival formalin-fixed, paraffin-embedded tissue sections from verrucous carcinoma of the larynx was determined using immunohistochemistry.The p53 oncoprotein was detected in four of 10 tissue samples (40 per cent). The same number of tumours had HPV antigen, and three cases had both p53 oncoprotein and HPV antigen. All positive cases were from heavy smokers and drinkers.After surgical treatment, no tumour recurrence was present in our series. Four patients developed a second head and neck neoplasm and death occurred in three. Three of the patients with second tumour had p53 positive immunoreactivity and two had p13 and HPV expression.Verrucous carcinoma of the larynx presented with overexpression of p53 antigen in a similar percentage to other head and neck cancers. The p53 immunohistochemical determination is well correlated with HPV detection and could have prognostic value in these tumours, but no statistical evidence was present.

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