Hydrochloride Salt

2020 ◽  
Author(s):  
Keyword(s):  
Hydrochloride Salt

Synthesis and Assessment of Novel Anti-chlamydial Benzylidene Acylhydrazides Derivatives

2018 ◽  
Vol 15 (1) ◽  
pp. 31-36 ◽  
Author(s):  
Xiaofeng Bao ◽  
Ying Xue ◽  
Chao Xia ◽  
Yin Lu ◽  
Ningjing Yang ◽  
...  
Keyword(s):  
Inhibitory Effect ◽  
Dependent Manner ◽  
Iron Starvation ◽  
Hydrochloride Salt ◽  
Obligate Intracellular ◽  
Biphasic Life Cycle ◽  
Ic50 Value ◽  
Ic50 Values ◽  
Dose Dependent ◽  
Better Than

Background: Chlamydiae, characterized by a unique biphasic life cycle, are a group of Gram-negative obligate intracellular bacterial pathogens responsible for diseases in a range of hosts including humans. Benzylidene acylhydrazide CF0001 could inhibit chlamydiae independent of iron starvation and T3SS inhibition. This finding promoted us to design and synthesize more benzylidene acylhydrazides to find novel anti-chlamydial agents. Methods: The carboxylic acids 1a-1d were coupled with Boc-hydrazide inpresence of EDCI and DMAP to obtain the intermediate 2a-2d in 60-62% yields. N-Boc deprotections were performed to obtain hydrazide hydrochloride salt 3a-3d. Nextly, the hydrazides were subjected to condensation with aldehydes to obtain benzylidene acylhydrazides 4a-4g in 30-52% yields in two steps. Results: Compound 4d exhibited best inhibitory effect on the formation and growth of chlamydial inclusions. The IC50 value of compound 4d for infectious progenies was 3.55 µM, better than 7.30 µM of CF0001. Conclusion: To find novel anti-chlamydial agents, we have designed and synthesized benzylidene acylhydrazides 4a-4g. Compounds 4a, 4d, 4g showed inhibitory activity on C. muridarum with the IC50 values from 3.55-12 µM. The 3,5-dibromo-4-hydroxyl substitutes on ring B are critical to keep their anti-chlamydial activity. Compound 4d inhibited C. muridarum in a dose-dependent manner without apparent cytotoxicity.

An Efficient and Improved Process for the Synthesis of Itopride Hydrochloride and Trimethobenzamide Hydrochloride

2018 ◽  
Vol 15 (4) ◽  
pp. 572-575 ◽  
Author(s):  
Ponnusamy Kannan ◽  
Samuel I.D. Presley ◽  
Pallikondaperumal Shanmugasundaram ◽  
Nagapillai Prakash ◽  
Deivanayagam Easwaramoorthy
Keyword(s):  
Large Scale ◽  
Hydroxylamine Hydrochloride ◽  
Scale Production ◽  
One Pot ◽  
Hydrochloride Salt ◽  
Environmental Friendly ◽  
Large Scale Production ◽  
Non Ulcer Dyspepsia ◽  
Itopride Hydrochloride ◽  
Yield And Purity

Aim and Objective: Itopride is a prokinetic agent used for treating conditions like non-ulcer dyspepsia. Itopride is administered as its hydrochloride salt. Trimethobenzamide is used for treating nausea and vomiting and administered as its hydrochloride salt. The aim is to develop a novel and environmental friendly method for large-scale production of itopride and trimethobenzamide. Materials and Methods: Itopride and trimethobenzamide can be prepared from a common intermediate 4- (dimethylaminoethoxy) benzyl amine. The intermediate is prepared from one pot synthesis using Phyrdroxybenzaldehye and zinc dust and further reaction of the intermediate with substituted methoxy benzoic acid along with boric acid and PEG gives itopride and trimethobenzamide. Results: The intermediate 4-(dimethylaminoethoxy) benzylamine is prepared by treating p-hydroxybenzaldehyde and 2-dimethylaminoethyl chloride. The aldehyde formed is treated with hydroxylamine hydrochloride. The intermediate is confirmed by NMR and the purity is analysed by HPLC. Conclusion: Both itopride and trimethobenzamide were successfully synthesized by this method. The developed method is environmental friendly, economical for large-scale production with good yield and purity.

Extraction of molybdenum(VI) by hydrochloride salt of tri-isooctylamine

1977 ◽  
Vol 39 (4) ◽  
pp. 645-647 ◽  
Author(s):  
A.S. Vieux ◽  
N. Rutagengwa ◽  
L. Basosila
Keyword(s):  
Hydrochloride Salt

The structure of the hydrochloride salt of Trp-Met-Asp-Phe-NH2.CH3OH.0.5C2H5OC2H5, the C-terminal tetrapeptide amide of gastrin

1982 ◽  
Vol 38 (6) ◽  
pp. 1758-1764 ◽  
Author(s):  
W. B. T. Cruse ◽  
E. Egert ◽  
M. A. Viswamitra ◽  
O. Kennard
Keyword(s):  
Hydrochloride Salt

Host–guest interaction of hemicucurbiturils with phenazine hydrochloride salt

2014 ◽  
Vol 27 (1-2) ◽  
pp. 37-43 ◽  
Author(s):  
Ding-Ding Xiang ◽  
Qing-Xia Geng ◽  
Hang Cong ◽  
Zhu Tao ◽  
Takehiko Yamato
Keyword(s):  
Hydrochloride Salt

Multicentre hydrogen bonds in a 2:1 arylsulfonylimidazolone hydrochloride salt

2000 ◽  
Vol 56 (10) ◽  
pp. 1247-1250 ◽  
Author(s):  
Kyung-Lae Park ◽  
Byoung-Gi Moon ◽  
Sang-Hun Jung ◽  
Jin-Gyu Kim ◽  
Il-Hwan Suh
Keyword(s):  
Hydrogen Bonds ◽  
Hydrochloride Salt

1H and13C NMR Studies of Etidocaine Free Base and Hydrochloride Salt. Solvent and Temperature Dependence

1992 ◽  
Vol 25 (1) ◽  
pp. 133-161
Author(s):  
Laurine A. LaPlanche ◽  
Robert Rothchild ◽  
Yangdong Xu
Keyword(s):  
Temperature Dependence ◽  
Free Base ◽  
Nmr Studies ◽  
1H And13c Nmr ◽  
Hydrochloride Salt
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