scholarly journals Upstream Stimulatory Factor 1

2020 ◽  
Author(s):  
Keyword(s):  
Upstream Stimulatory Factor ◽  
Upstream Stimulatory Factor 1 ◽  
Stimulatory Factor

Upstream stimulatory factor 1 associated with familial combined hyperlipidemia, LDL cholesterol, and triglycerides

2005 ◽  
Vol 117 (5) ◽  
pp. 444-451 ◽  
Author(s):  
Hilary Coon ◽  
Yuanpei Xin ◽  
Paul N. Hopkins ◽  
Richard M. Cawthon ◽  
Sandra J. Hasstedt ◽  
...  
Keyword(s):  
Ldl Cholesterol ◽  
Upstream Stimulatory Factor ◽  
Familial Combined Hyperlipidemia ◽  
Upstream Stimulatory Factor 1 ◽  
Stimulatory Factor

Transcriptional regulation of the human cystathionine β-synthase −1b basal promoter: synergistic transactivation by transcription factors NF-Y and Sp1/Sp3

2001 ◽  
Vol 357 (1) ◽  
pp. 97-105 ◽  
Author(s):  
Yubin GE ◽  
Mark A. KONRAD ◽  
Larry H. MATHERLY ◽  
Jeffrey W. TAUB
Keyword(s):  
Reporter Gene ◽  
Intermediate Step ◽  
Nuclear Factor ◽  
Upstream Stimulatory Factor ◽  
E Box ◽  
Gc Box ◽  
Specific Regulation ◽  
Specificity Protein ◽  
Upstream Stimulatory Factor 1 ◽  
Stimulatory Factor

Cystathionine β-synthase (CBS) catalyses the condensation of serine and homocysteine to form cystathionine, an intermediate step in the synthesis of cysteine. Human CBS encodes five distinct 5′ non-coding exons, the most frequent termed CBS −1a and CBS −1b, each transcribed from its own unique GC-rich TATA-less promoter. The minimal transcriptional region (−3792 to −3667) of the CBS −1b promoter was defined by 5′- and 3′-deletions, and transient transfections of reporter gene constructs in HepG2 cells, characterized by CBS transcription exclusively from the −1b promoter. Included in this 125bp region are 3 GC-boxes (termed GC-a, GC-b and GC-c), an inverted CAAT-box and an E-box. By gel-shift and supershift assays, binding of specificity protein (Sp)1 and Sp3 to the GC-box elements, upstream stimulatory factor 1 (USF-1) to the E-box, and both nuclear factor (NF)-Y and an NF-1-like factor to the CAAT box could be demonstrated. By transient trans fections and reporter gene assays in HepG2 and Drosophila SL2 cells, a functional interplay was indicated between NF-Y binding to the CAAT-box, or between USF-1 binding to the E-box, and Sp1/Sp3 binding to the GC-box elements. In SL2 cells, NF-Y and Sp1/Sp3 were synergistic. Furthermore, both Sp1 and the long Sp3 isoform transactivated the CBS −1b minimal promoter; however, the short Sp3 isoforms were potent repressors. These results may explain the cell- or tissue-specific regulation of CBS transcription, and clarify the bases for alterations in CBS gene expression in human disease and Down's syndrome.

Polymorphism rs3737787 of Upstream Stimulatory Factor 1 gene is associated with serum lipid phenotype in Nigerian population

2021 ◽  
Vol 55 ◽  
pp. 101687
Author(s):  
Oluwadamilola T. Onadeko ◽  
Wahab O. Okunowo ◽  
Ngozi.O.A. Imaga ◽  
Muhammed M. Abdulrazaq ◽  
Onuminya J. Onuminya ◽  
...  
Keyword(s):  
Serum Lipid ◽  
Upstream Stimulatory Factor ◽  
Lipid Phenotype ◽  
Nigerian Population ◽  
Upstream Stimulatory Factor 1 ◽  
Stimulatory Factor

scholarly journals Kbtbd11 contributes to adipocyte homeostasis through the activation of upstream stimulatory factor 1

Heliyon ◽  
2019 ◽  
Vol 5 (11) ◽  
pp. e02777 ◽  
Author(s):  
Kazuhisa Watanabe ◽  
Kazuha Yokota ◽  
Ken Yoshida ◽  
Ayumi Matsumoto ◽  
Sadahiko Iwamoto
Keyword(s):  
Upstream Stimulatory Factor ◽  
Upstream Stimulatory Factor 1 ◽  
Stimulatory Factor
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