scholarly journals Argentine hemorrhagic fever

2020 ◽  
Author(s):  
Keyword(s):  
Hemorrhagic Fever ◽  
Argentine Hemorrhagic Fever

Factor VIII : C and Factor VIII R: Ag in Argentine Hemorrhagic Fever

1981 ◽  
Vol 46 (02) ◽  
pp. 525-527 ◽  
Author(s):  
Felisa C Molinas ◽  
Julio I Maiztegui
Keyword(s):  
Factor Viii ◽  
Normal Values ◽  
Hemorrhagic Fever ◽  
Plasma Samples ◽  
Two Dimensional ◽  
Plasma Infusion ◽  
Factor Viii Related Antigen ◽  
Clinical Forms ◽  
Argentine Hemorrhagic Fever ◽  
Immune Precipitation

SummaryFactor VIII procoagulant activity (F VIII: C) and factor VIII related antigen (F VIII R: Ag) were investigated in 35 patients with Argentine hemorrhagic fever. Since the results obtained in the three clinical forms of the disease were not significantly different, they were tabulated altogether. F VIII: C was low in early stages of the disease but increased progressively in later days (days 5–6:0.54 ± 0.10 I.U./ml; days 13–14:0.95 ± 0.13 I.U./ml). In contrst, the levels of F VIII R: Ag were high all along the disease and they returned to normal values during the convalescence period (days 5–6; 2.58 ± 0.54 I.U./ml; day 30: 1.30 ± 0.14 I.U./ml). The levels of F VIII R: Ag were similar in samples drawn before (11 cases) or after (10 cases) the treatment with immune plasma infusion. Plasma samples from 12 patients were studied by two-dimensional immunelectrophoresis. The only abnormality found was increased height of the immune precipitation arc.

Safety and Immunogenicity of a Live-Attenuated Junin (Argentine Hemorrhagic Fever) Vaccine in Rhesus Macaques

1993 ◽  
Author(s):  
Kelly T. McKee ◽  
Oro Jr. ◽  
Kuehne Julio G. ◽  
Spisso Anna I. ◽  
Mahlandt Joan A. ◽  
...  
Keyword(s):  
Rhesus Macaques ◽  
Hemorrhagic Fever ◽  
Argentine Hemorrhagic Fever

Junin virus activity in two rural populations of the Argentine hemorrhagic fever (AHF) endemic area

1983 ◽  
Vol 12 (4) ◽  
pp. 273-280 ◽  
Author(s):  
Mercedes C. Weissenbacher ◽  
Marta S. Sabattini ◽  
María M. Avila ◽  
Patricia M. Sangiorgio ◽  
María R. F. De Sensi ◽  
...  
Keyword(s):  
Endemic Area ◽  
Hemorrhagic Fever ◽  
Rural Populations ◽  
Junin Virus ◽  
Argentine Hemorrhagic Fever ◽  
Virus Activity ◽  
Junín Virus

scholarly journals Treatment of Argentine hemorrhagic fever

2008 ◽  
Vol 78 (1) ◽  
pp. 132-139 ◽  
Author(s):  
Delia A. Enria ◽  
Ana M. Briggiler ◽  
Zaida Sánchez
Keyword(s):  
Hemorrhagic Fever ◽  
Argentine Hemorrhagic Fever

Ultrastructural and Immunohistochemical Studies in Five Cases of Argentine Hemorrhagic Fever

1975 ◽  
Vol 132 (1) ◽  
pp. 35-43 ◽  
Author(s):  
J. I. Maiztegui ◽  
R. P. Laguens ◽  
P. M. Cossio ◽  
M. B. Casanova ◽  
M. T. de la Vega ◽  
...  
Keyword(s):  
Hemorrhagic Fever ◽  
Argentine Hemorrhagic Fever ◽  
Immunohistochemical Studies

Argentine Hemorrhagic Fever

2012 ◽  
pp. 240-240
Author(s):  
Howard R. Champion ◽  
Nova L. Panebianco ◽  
Jan J. De Waele ◽  
Lewis J. Kaplan ◽  
Manu L. N. G. Malbrain ◽  
...  
Keyword(s):  
Hemorrhagic Fever ◽  
Argentine Hemorrhagic Fever

Argentine Hemorrhagic Fever

1987 ◽  
pp. 79-116 ◽  
Author(s):  
M. C. Weissenbacher ◽  
R. P. Laguens ◽  
C. E. Coto
Keyword(s):  
Hemorrhagic Fever ◽  
Argentine Hemorrhagic Fever

scholarly journals Novel Arenavirus Entry Inhibitors Discovered by Using a Minigenome Rescue System for High-Throughput Drug Screening

2015 ◽  
Vol 89 (16) ◽  
pp. 8428-8443 ◽  
Author(s):  
Jessica Y. Rathbun ◽  
Magali E. Droniou ◽  
Robert Damoiseaux ◽  
Kevin G. Haworth ◽  
Jill E. Henley ◽  
...  
Keyword(s):  
High Throughput ◽  
Causative Agent ◽  
High Throughput Screening ◽  
Hemorrhagic Fever ◽  
Human Pathogens ◽  
Junin Virus ◽  
Hemorrhagic Fevers ◽  
Argentine Hemorrhagic Fever ◽  
Rescue System ◽  
Junín Virus

ABSTRACTCertain members of theArenaviridaefamily are category A agents capable of causing severe hemorrhagic fevers in humans. Specific antiviral treatments do not exist, and the only commonly used drug, ribavirin, has limited efficacy and can cause severe side effects. The discovery and development of new antivirals are inhibited by the biohazardous nature of the viruses, making them a relatively poorly understood group of human pathogens. We therefore adapted a reverse-genetics minigenome (MG) rescue system based on Junin virus, the causative agent of Argentine hemorrhagic fever, for high-throughput screening (HTS). The MG rescue system recapitulates all stages of the virus life cycle and enables screening of small-molecule libraries under biosafety containment level 2 (BSL2) conditions. The HTS resulted in the identification of four candidate compounds with potent activity against a broad panel of arenaviruses, three of which were completely novel. The target for all 4 compounds was the stage of viral entry, which positions the compounds as potentially important leads for future development.IMPORTANCEThe arenavirus family includes several members that are highly pathogenic, causing acute viral hemorrhagic fevers with high mortality rates. No specific effective treatments exist, and although a vaccine is available for Junin virus, the causative agent of Argentine hemorrhagic fever, it is licensed for use only in areas where Argentine hemorrhagic fever is endemic. For these reasons, it is important to identify specific compounds that could be developed as antivirals against these deadly viruses.

scholarly journals A Host-Oriented Inhibitor of Junin Argentine Hemorrhagic Fever Virus Egress

2014 ◽  
Vol 88 (9) ◽  
pp. 4736-4743 ◽  
Author(s):  
J. Lu ◽  
Z. Han ◽  
Y. Liu ◽  
W. Liu ◽  
M. S. Lee ◽  
...  
Keyword(s):  
Hemorrhagic Fever ◽  
Fever Virus ◽  
Hemorrhagic Fever Virus ◽  
Argentine Hemorrhagic Fever ◽  
Virus Egress
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