scholarly journals Lung Disorder

2020 ◽  
Author(s):  
Keyword(s):  
Lung Disorder

Changes Of The Innate Immune Response In Relation With The Type Of The Interstitial Lung Disorder

2012 ◽  
Author(s):  
Ilias Papanikolaou ◽  
Kyriaki Boki ◽  
Evangelos J. Giamarellos-Bourboulis ◽  
Antigoni Kotsaki ◽  
Napoleon Karagiannidis ◽  
...  
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Lung Disorder

scholarly journals Alveolar capillary dysplasia with misalignment of the pulmonary veins: clinical, histological, and genetic aspects

2018 ◽  
Vol 8 (3) ◽  
pp. 204589401879514 ◽  
Author(s):  
Evelien Slot ◽  
Gabriëla Edel ◽  
Ernest Cutz ◽  
Arno van Heijst ◽  
Martin Post ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Molecular Mechanism ◽  
Pulmonary Veins ◽  
Clinical Aspects ◽  
Lung Disorder ◽  
Genetic Studies ◽  
Ongoing Research ◽  
Alveolar Capillary Dysplasia ◽  
Alveolar Capillary ◽  
Severe Lung

Alveolar capillary dysplasia with misalignment of the pulmonary veins (ACD/MPV) is a rare and lethal disorder mainly involving the vascular development of the lungs. Since its first description, significant achievements in research have led to a better understanding of the underlying molecular mechanism of ACD/MPV and genetic studies have identified associations with genomic alterations in the locus of the transcription factor FOXF1. This in turn has increased the awareness among clinicians resulting in over 200 cases reported so far, including genotyping of patients in most recent reports. Collectively, this promoted a better stratification of the patient group, leading to new perspectives in research on the pathogenesis. Here, we provide an overview of the clinical aspects of ACD/MPV, including guidance for clinicians, and review the ongoing research into the complex molecular mechanism causing this severe lung disorder.

Comprehensive Analysis of Bortezomib-Induced Adverse Events Using the Japanese Real-World Database

Oncology ◽  
2021 ◽  
Author(s):  
Aya Satoki ◽  
Mayako Uchida ◽  
Masaki Fujiwara ◽  
Yoshihiro Uesawa ◽  
Tadashi Shimizu
Keyword(s):  
Peripheral Neuropathy ◽  
Adverse Events ◽  
Cardiac Failure ◽  
Tumor Lysis Syndrome ◽  
Adverse Event Reporting System ◽  
Japanese Patients ◽  
Comprehensive Analysis ◽  
Drug Event ◽  
Lung Disorder ◽  
Time To Onset

Background: Bortezomib is used as first-line therapy for multiple myeloma. Observational studies based on the FDA Adverse Event Reporting System (FAERS) database analysis and systematic reviews indicate that the incidence of peripheral neuropathy and tumor lysis syndrome (TLS) tends to be higher with bortezomib than that of other drugs. In a comprehensive analysis assessing drugs that cause peripheral neuropathy in Japanese patients, the incidence of bortezomib-induced adverse events (AEs) was reportedly high. However, a comprehensive assessment of bortezomib is lacking. Objectives: The purpose of this study was to determine the frequency of bortezomib AEs in Japanese patients and to determine the incidence, time to onset, and post hoc outcomes of unique AEs using the Japanese Adverse Drug Event Report (JADER) database. Method: To investigate the association between bortezomib and AEs, we analyzed the JADER database, which contains spontaneous AE reports submitted to the Pharmaceuticals and Medical Devices Agency from April 2004 to December 2020. Criteria indicating the presence of an AE signal were met when the following requirements were fulfilled: proportional reporting ratios (PRR) ≥ 2 and χ2 ≥ 4. Time to onset and post-event outcomes were analyzed for characteristic AEs. Results: Among 26 extracted AEs, 13 presented AE signals. The post-exposure outcomes of 12 AEs showed fatal outcomes at rates exceeding 10%, including cardiac failure (30%), lung disorder (24%), pneumonia (18%), and TLS (10%). Furthermore, a histogram of time to onset revealed that the 12 AEs were concentrated from the beginning to approximately one month after bortezomib administration. The median onset times for cardiac failure, lung disorder, pneumonia, and TLS were 28, 13, 42, and 5 days, respectively. Conclusions: Cardiac failure, lung disorder, pneumonia, and TLS had a higher rate of fatal clinical outcomes after onset than other AEs. These AEs exhibited a greater onset tendency in the early post-dose period. This study suggests that there is a need to monitor signs of cardiac failure, lung disorder, pneumonia, and TLS, potentially resulting in serious outcomes.

scholarly journals Cigarette smoking, cadmium exposure, and zinc intake on obstructive lung disorder

2010 ◽  
Vol 11 (1) ◽  
Author(s):  
Yu-Sheng Lin ◽  
James L Caffrey ◽  
Man-Huei Chang ◽  
Nicole Dowling ◽  
Jou-Wei Lin
Keyword(s):  
Cigarette Smoking ◽  
Cadmium Exposure ◽  
Lung Disorder ◽  
Zinc Intake

From the NIH. Estrogen may protect against lung disorder

JAMA ◽  
1985 ◽  
Vol 254 (19) ◽  
pp. 2721-2721
Author(s):  
D. Brody
Keyword(s):  
Lung Disorder

The Effect of Pulmonary Rehabilitation in Patients With Post-tuberculosis Lung Disorder

CHEST Journal ◽  
2003 ◽  
Vol 123 (6) ◽  
pp. 1988-1995 ◽  
Author(s):  
Morihide Ando ◽  
Atsushi Mori ◽  
Hiroshi Esaki ◽  
Tsuyoshi Shiraki ◽  
Hiroyuki Uemura ◽  
...  
Keyword(s):  
Pulmonary Rehabilitation ◽  
Lung Disorder

scholarly journals A Review of Placenta and Umbilical Cord-Derived Stem Cells and the Immunomodulatory Basis of Their Therapeutic Potential in Bronchopulmonary Dysplasia

2021 ◽  
Vol 9 ◽  
Author(s):  
Wai Kit Chia ◽  
Fook Choe Cheah ◽  
Nor Haslinda Abdul Aziz ◽  
Nirmala Chandralega Kampan ◽  
Salwati Shuib ◽  
...  
Keyword(s):  
Stem Cells ◽  
Umbilical Cord ◽  
Bronchopulmonary Dysplasia ◽  
Therapeutic Potential ◽  
Therapeutic Agents ◽  
Lung Disorder ◽  
Routes Of Administration ◽  
Injured Lung ◽  
Preclinical And Clinical Studies ◽  
Modern Era

Bronchopulmonary dysplasia (BPD) is a devastating lung disorder of preterm infants as a result of an aberrant reparative response following exposures to various antenatal and postnatal insults. Despite sophisticated medical treatment in this modern era, the incidence of BPD remains unabated. The current strategies to prevent and treat BPD have met with limited success. The emergence of stem cell therapy may be a potential breakthrough in mitigating this complex chronic lung disorder. Over the last two decades, the human placenta and umbilical cord have gained increasing attention as a highly potential source of stem cells. Placenta-derived stem cells (PDSCs) and umbilical cord-derived stem cells (UCDSCs) display several advantages such as immune tolerance and are generally devoid of ethical constraints, in addition to their stemness qualities. They possess the characteristics of both embryonic and mesenchymal stromal/stem cells. Recently, there are many preclinical studies investigating the use of these cells as therapeutic agents in neonatal disease models for clinical applications. In this review, we describe the preclinical and clinical studies using PDSCs and UCDSCs as treatment in animal models of BPD. The source of these stem cells, routes of administration, and effects on immunomodulation, inflammation and regeneration in the injured lung are also discussed. Lastly, a brief description summarized the completed and ongoing clinical trials using PDSCs and UCDSCs as therapeutic agents in preventing or treating BPD. Due to the complexity of BPD, the development of a safe and efficient therapeutic agent remains a major challenge to both clinicians and researchers.

scholarly journals A Deep Convolutional Neural Network Based Lung Disorder Diagnosis

2019 ◽  
pp. 102-112
Author(s):  
J. Juditha Mercina ◽  
J. Madhumathi ◽  
V. Priyanga ◽  
M. Deva Priya
Keyword(s):  
Neural Network ◽  
Neural Networks ◽  
Lung Disease ◽  
Lung Diseases ◽  
Intelligent System ◽  
Lung Disorder ◽  
X Ray ◽  
Cad System ◽  
Computer Aided ◽  
Aided Diagnosis

Lungs play an important role in human respiratory system. There are diseases that affect the functioning of lungs. To analyse lung diseases in the chest region using X-ray based Computer-Aided Diagnosis (CAD) system, it is necessary to determine the lung regions subject to analysis. In this paper, an intelligent system is proposed for lung disease detection. In this paper, Interstitial Lung Disease (ILD) patterns are classified using Convolutional Neural Networks (CNN). The proposed system involves five convolutional layers and three dense layers. The performance of the classification demonstrates the potential of CNN in analysing lung patterns.

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