scholarly journals Endothelin-3

2020 ◽  
Author(s):  
Keyword(s):  
Endothelin 3

scholarly journals A Complex Genomic Rearrangement Involving the Endothelin 3 Locus Causes Dermal Hyperpigmentation in the Chicken

PLoS Genetics ◽  
2011 ◽  
Vol 7 (12) ◽  
pp. e1002412 ◽  
Author(s):  
Ben Dorshorst ◽  
Anna-Maja Molin ◽  
Carl-Johan Rubin ◽  
Anna M. Johansson ◽  
Lina Strömstedt ◽  
...  
Keyword(s):  
Genomic Rearrangement ◽  
Complex Genomic Rearrangement ◽  
Endothelin 3

Functional Properties of High- and Low-Affinity Receptor Subtypes for Endothelin-3

1991 ◽  
Vol 17 ◽  
pp. S131-133 ◽  
Author(s):  
Christian Frelin ◽  
Annie Ladoux ◽  
Robert Marsault ◽  
Paul Vigne
Keyword(s):  
Functional Properties ◽  
Receptor Subtypes ◽  
Affinity Receptor ◽  
Endothelin 3

Akt and PI3K-dependent but CREB-independent upregulation of MCAM by endothelin-3 in human melanocytes

2014 ◽  
Vol 24 (4) ◽  
pp. 404-407 ◽  
Author(s):  
Brittny Williams ◽  
Robert J. Schneider ◽  
Sumayah Jamal
Keyword(s):  
Human Melanocytes ◽  
Endothelin 3

Endothelin-1 and endothelin-3 in cirrhosis: Relations to systemic and splanchnic haemodynamics

1995 ◽  
Vol 23 (2) ◽  
pp. 135-144 ◽  
Author(s):  
Søren Møller ◽  
Veit Gülberg ◽  
Jens H. Henriksen ◽  
Alexander L. Gerbes
Keyword(s):  
Endothelin 1 ◽  
Endothelin 3

The neural crest population responding to endothelin-3 in vitro includes multipotent cells

1997 ◽  
Vol 110 (14) ◽  
pp. 1673-1682 ◽  
Author(s):  
J.G. Stone ◽  
L.I. Spirling ◽  
M.K. Richardson
Keyword(s):  
Neural Crest ◽  
Schwann Cells ◽  
Cell Types ◽  
Developmental Potential ◽  
Colony Assay ◽  
Cellular Targets ◽  
Multipotent Cells ◽  
Endothelin 3

The peptide endothelin 3 (EDN3) is essential for normal neural crest development in vivo, and is a potent mitogen for quail truncal crest cells in vitro. It is not known which subpopulations of crest cells are targets for this response, although it has been suggested that EDN3 is selective for melanoblasts. In the absence of cell markers for different precursor types in the quail crest, we have characterised EDN3-responsive cell types using in vitro colony assay and clonal analysis. Colonies were analysed for the presence of Schwann cells, melanocytes, adrenergic cells or sensory-like cells. We provide for the first time a description of the temporal pattern of lineage segregation in neural crest cultures. In the absence of exogenous EDN3, crest cells proliferate and then differentiate. Colony assay indicates that in these differentiated cultures few undifferentiated precursors remain and there is a low replating efficiency. By contrast, in the presence of 100 ng/ml EDN3 differentiation is inhibited and most of the cells maintain the ability to give rise to mixed colonies and clones containing neural crest derivatives. A high replating efficiency is maintained. In secondary culture there was a progressive decline in the number of cell types per colony in control medium. This loss of developmental potential was not seen when exogenous EDN3 was present. Cell type analysis suggests two novel cellular targets for EDN3 under these conditions. Contrary to expectations, one is a multipotent precursor whose descendants include melanocytes, adrenergic cells and sensory-like cells; the other can give rise to melanocytes and Schwann cells. Our data do not support previous claims that the action of EDN3 in neural crest culture is selective for cells in the melanocyte lineage.

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