scholarly journals Kinesin Light Chain 1

2020 ◽  
Author(s):  
Keyword(s):  
Light Chain ◽  
Kinesin Light Chain

scholarly journals Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-  accumulation modifier

2014 ◽  
Vol 111 (7) ◽  
pp. 2638-2643 ◽  
Author(s):  
T. Morihara ◽  
N. Hayashi ◽  
M. Yokokoji ◽  
H. Akatsu ◽  
M. A. Silverman ◽  
...  
Keyword(s):  
Light Chain ◽  
Transcriptome Analysis ◽  
Mouse Strains ◽  
Kinesin Light Chain ◽  
Amyloid Accumulation

scholarly journals Association of the Herpes Simplex Virus Type 1 Us11 Gene Product with the Cellular Kinesin Light-Chain-Related Protein PAT1 Results in the Redistribution of Both Polypeptides

2003 ◽  
Vol 77 (17) ◽  
pp. 9192-9203 ◽  
Author(s):  
Louisa Benboudjema ◽  
Matthew Mulvey ◽  
Yuehua Gao ◽  
Sanjay W. Pimplikar ◽  
Ian Mohr
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Light Chain ◽  
Herpes Simplex Virus Type ◽  
Nuclear Export ◽  
Kinesin Light Chain ◽  
Dsrna Binding ◽  
Infected Cells ◽  
Simplex Virus

ABSTRACT The herpes simplex virus type 1 (HSV-1) Us11 gene encodes a multifunctional double-stranded RNA (dsRNA)-binding protein that is expressed late in infection and packaged into the tegument layer of the virus particle. As a tegument component, Us11 associates with nascent capsids after its synthesis late in the infectious cycle and is delivered into newly infected cells at times prior to the expression of viral genes. Us11 is also an abundant late protein that regulates translation through its association with host components and contains overlapping nucleolar retention and nuclear export signals, allowing its accumulation in both nucleoli and the cytosol. Thus, at various times during the viral life cycle and in different intracellular compartments, Us11 has the potential to execute discrete tasks. The analysis of these functions, however, is complicated by the fact that Us11 is not essential for viral replication in cultured cells. To discover new host targets for the Us11 protein, we searched for cellular proteins that interact with Us11 and have identified PAT1 as a Us11-binding protein according to multiple, independent experimental criteria. PAT1 binds microtubules, participates in amyloid precursor protein trafficking, and has homology to the kinesin light chain (KLC) in its carboxyl terminus. The carboxyl-terminal dsRNA-binding domain of Us11, which also contains the nucleolar retention and nuclear export signals, binds PAT1, whereas 149 residues derived from the KLC homology region of PAT1 are important for binding to Us11. Both PAT1 and Us11 colocalize within a perinuclear area in transiently transfected and HSV-1-infected cells. The 149 amino acids derived from the KLC homology region are required for colocalization of the two polypeptides. Furthermore, although PAT1 normally accumulates in the nuclear compartment, Us11 expression results in the exclusion of PAT1 from the nucleus and its accumulation in the perinuclear space. Similarly, Us11 does not accumulate in the nucleoli of infected cells that overexpress PAT1. These results establish that Us11 and PAT1 can associate, resulting in an altered subcellular distribution of both polypeptides. The association between PAT1, a cellular trafficking protein with homology to KLC, and Us11, along with a recent report demonstrating an interaction between Us11 and the ubiquitous kinesin heavy chain (R. J. Diefenbach et al., J. Virol. 76:3282-3291, 2002), suggests that these associations may be important for the intracellular movement of viral components.

scholarly journals Characterization of the binding mode of JNK-interacting protein 1 (JIP1) to kinesin-light chain 1 (KLC1)

2018 ◽  
Vol 293 (36) ◽  
pp. 13946-13960 ◽  
Author(s):  
T. Quyen Nguyen ◽  
Magali Aumont-Nicaise ◽  
Jessica Andreani ◽  
Christophe Velours ◽  
Mélanie Chenon ◽  
...  
Keyword(s):  
Light Chain ◽  
Binding Mode ◽  
Interacting Protein ◽  
Kinesin Light Chain

scholarly journals The Kinesin Light Chain–Related Protein PAT1 Promotes Superoxide Anion Production in Human Phagocytes

2019 ◽  
Vol 202 (5) ◽  
pp. 1549-1558
Author(s):  
Riad Arabi-Derkawi ◽  
Yvonne O’Dowd ◽  
Ni Cheng ◽  
Loïc Rolas ◽  
Tarek Boussetta ◽  
...  
Keyword(s):  
Light Chain ◽  
Superoxide Anion ◽  
Related Protein ◽  
Superoxide Anion Production ◽  
Kinesin Light Chain ◽  
Anion Production

scholarly journals Bacterial kinesin light chain (Bklc) links the Btub cytoskeleton to membranes

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Lurlène Akendengue ◽  
Sylvain Trépout ◽  
Martín Graña ◽  
Alexis Voegele ◽  
Carsten Janke ◽  
...  
Keyword(s):  
Light Chain ◽  
Kinesin Light Chain

Cloning and Genetic Characterization of the Human Kinesin Light-Chain (KLC) Gene

1993 ◽  
Vol 12 (10) ◽  
pp. 881-892 ◽  
Author(s):  
YOFRE CABEZA-ARVELAIZ ◽  
LI-CHEN NANCY SHIH ◽  
NORMAN HARDMAN ◽  
FRED ASSELBERGS ◽  
GRAEME BILBE ◽  
...  
Keyword(s):  
Light Chain ◽  
Genetic Characterization ◽  
Kinesin Light Chain

Kinesin Light Chain in a Eubacterium

1997 ◽  
Vol 16 (6) ◽  
pp. 787-795 ◽  
Author(s):  
MARTINA CELERIN ◽  
ANDREA A. GILPIN ◽  
GILBERT DOSSANTOS ◽  
DAVID E. LAUDENBACH ◽  
MICHAEL W. CLARKE ◽  
...  
Keyword(s):  
Light Chain ◽  
Kinesin Light Chain

scholarly journals Release of Kinesin from Vesicles by hsc70 and Regulation of Fast Axonal Transport

2000 ◽  
Vol 11 (6) ◽  
pp. 2161-2173 ◽  
Author(s):  
Ming-Ying Tsai ◽  
Gerardo Morfini ◽  
Györgyi Szebenyi ◽  
Scott T. Brady
Keyword(s):  
Axonal Transport ◽  
Light Chain ◽  
Tandem Repeats ◽  
Light Chains ◽  
Fast Axonal Transport ◽  
Kinesin Light Chain ◽  
Highly Sensitive ◽  
Subcellular Domains ◽  
Buffer Composition ◽  
Membrane Bound

The nature of kinesin interactions with membrane-bound organelles and mechanisms for regulation of kinesin-based motility have both been surprisingly difficult to define. Most kinesin is recovered in supernatants with standard protocols for purification of motor proteins, but kinesin recovered on membrane-bound organelles is tightly bound. Partitioning of kinesin between vesicle and cytosolic fractions is highly sensitive to buffer composition. Addition of eitherN-ethylmaleimide or EDTA to homogenization buffers significantly increased the fraction of kinesin bound to organelles. Given that an antibody against kinesin light chain tandem repeats also releases kinesin from vesicles, these observations indicated that specific cytoplasmic factors may regulate kinesin release from membranes. Kinesin light tandem repeats contain DnaJ-like motifs, so the effects of hsp70 chaperones were evaluated. Hsc70 released kinesin from vesicles in an MgATP-dependent andN-ethylmaleimide-sensitive manner. Recombinant kinesin light chains inhibited kinesin release by hsc70 and stimulated the hsc70 ATPase. Hsc70 actions may provide a mechanism to regulate kinesin function by releasing kinesin from cargo in specific subcellular domains, thereby effecting delivery of axonally transported materials.

The kinesin light chain gene: its mapping and exclusion in mouse and human forms of inherited motor neuron degeneration

1999 ◽  
Vol 273 (1) ◽  
pp. 49-52 ◽  
Author(s):  
Majid Hafezparast ◽  
Abi Witherden ◽  
Sharon Nicholson ◽  
Nessan Bermingham ◽  
James Mackin ◽  
...  
Keyword(s):  
Motor Neuron ◽  
Light Chain ◽  
Chain Gene ◽  
Motor Neuron Degeneration ◽  
Neuron Degeneration ◽  
Light Chain Gene ◽  
Kinesin Light Chain
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