scholarly journals Minor Salivary Gland Squamous Cell Carcinoma

2020 ◽  
Author(s):  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Salivary Gland ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Minor Salivary Gland

scholarly journals Determination of the origin of oral squamous cell carcinoma by microarray analysis: Squamous epithelium or minor salivary gland?

2018 ◽  
Vol 143 (10) ◽  
pp. 2551-2560 ◽  
Author(s):  
Makoto Kinouchi ◽  
Sayaka Izumi ◽  
Koh‐ichi Nakashiro ◽  
Yasuo Haruyama ◽  
Gen Kobashi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Salivary Gland ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Microarray Analysis ◽  
Squamous Cell ◽  
Squamous Epithelium ◽  
Minor Salivary Gland

scholarly journals Primary squamous cell carcinoma of major salivary gland: “Sapienza Head and Neck Unit” clinical recommendations

Rare Tumors ◽  
2020 ◽  
Vol 12 ◽  
pp. 203636132097352
Author(s):  
Silvia Mezi ◽  
Giulia Pomati ◽  
Andrea Botticelli ◽  
Francesca De Felice ◽  
Daniela Musio ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Salivary Gland ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Salivary Gland Tumor ◽  
Genetic Alterations ◽  
Integrated Treatment ◽  
Molecular Profile ◽  
Major Salivary Gland ◽  
Primary Squamous Cell Carcinoma

Primary squamous cell carcinoma of salivary gland (SCG) is an extremely rare type of malignant salivary gland tumor, which in turn results in scarcity of data available regarding both its treatment and associated genetic alterations. A retrospective analysis of 12 patients with primary SCG was conducted, along with analysis of the association between treatment, clinical/pathological characteristics, and outcomes. Most patients (8) were staged IVa, with the majority of them (10) having G3 fast growing cancer. Local and systemic recurrence were reported in only three out of nine parotid cases (0 out of 2 submandibular SCGs). In two out of eight patients local relapse occurred after integrated treatment, while recurrence occurred in two out of three patients undergoing exclusive surgery. Five patients eventually died. Treatment of resectable disease must be aggressive and multimodal, with achievement of loco-regional control in order to reduce rate of recurrence and improve outcomes. Metastatic disease would require a therapeutic strategy tailored to the molecular profile in order to improve the currently disappointing results.

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