scholarly journals Neuroepithelial Cell

2020 ◽  
Author(s):  
Keyword(s):  
Neuroepithelial Cell

scholarly journals Neuroepithelial cell competition triggers loss of cellular juvenescence

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Faidruz Azura Jam ◽  
Takao Morimune ◽  
Atsushi Tsukamura ◽  
Ayami Tano ◽  
Yuya Tanaka ◽  
...  
Keyword(s):  
Interaction Mechanism ◽  
Cell Interaction ◽  
Neuroepithelial Cell ◽  
Cell Competition ◽  
Early Brain Development ◽  
Associated Proteins ◽  
Model Cell ◽  
A Cell ◽  
Model Expression

Abstract Cell competition is a cell–cell interaction mechanism which maintains tissue homeostasis through selective elimination of unfit cells. During early brain development, cells are eliminated through apoptosis. How cells are selected to undergo elimination remains unclear. Here we aimed to identify a role for cell competition in the elimination of suboptimal cells using an in vitro neuroepithelial model. Cell competition was observed when neural progenitor HypoE-N1 cells expressing RASV12 were surrounded by normal cells in the co-culture. The elimination through apoptosis was observed by cellular changes of RASV12 cells with rounding/fragmented morphology, by SYTOX blue-positivity, and by expression of apoptotic markers active caspase-3 and cleaved PARP. In this model, expression of juvenility-associated genes Srsf7 and Ezh2 were suppressed under cell-competitive conditions. Srsf7 depletion led to loss of cellular juvenescence characterized by suppression of Ezh2, cell growth impairment and enhancement of senescence-associated proteins. The cell bodies of eliminated cells were engulfed by the surrounding cells through phagocytosis. Our data indicates that neuroepithelial cell competition may have an important role for maintaining homeostasis in the neuroepithelium by eliminating suboptimal cells through loss of cellular juvenescence.

Su1901 The Prognostic Significance of Neuroepithelial Cell Transforming Gene 1 in Adenocarcinoma of the Oesophago-Gastric Junction

2012 ◽  
Vol 142 (5) ◽  
pp. S-531
Author(s):  
Conor Lahiff ◽  
Niall J. Mulligan ◽  
Peter Doran ◽  
David W. Murray ◽  
Graham P. Pidgeon ◽  
...  
Keyword(s):  
Prognostic Significance ◽  
Neuroepithelial Cell ◽  
Cell Transforming ◽  
Transforming Gene

scholarly journals Ion Channel Activities in Neural Stem Cells of the Neuroepithelium

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Masayuki Yamashita
Keyword(s):  
Stem Cells ◽  
Membrane Potential ◽  
Neural Stem Cells ◽  
Nuclear Envelope ◽  
Electrical Coupling ◽  
Receptor Activation ◽  
S Phase ◽  
Basal Region ◽  
Neuroepithelial Cell ◽  
Neuroepithelial Cells

During the embryonic development of the central nervous system, neuroepithelial cells act as neural stem cells. They undergo interkinetic nuclear movements along their apico-basal axis during the cell cycle. The neuroepithelial cell shows robust increases in the nucleoplasmic [Ca2+] in response to G protein-coupled receptor activation in S-phase, during which the nucleus is located in the basal region of the neuroepithelial cell. This response is caused by Ca2+release from intracellular Ca2+stores, which are comprised of the endoplasmic reticulum and the nuclear envelope. The Ca2+release leads to the activation of Ca2+entry from the extracellular space, which is called capacitative, or store-operated Ca2+entry. These movements of Ca2+are essential for DNA synthesis during S-phase. Spontaneous Ca2+oscillations also occur synchronously across the cells. This synchronization is mediated by voltage fluctuations in the membrane potential of the nuclear envelope due to Ca2+release and the counter movement of K+ions; the voltage fluctuation induces alternating current (AC), which is transmitted via capacitative electrical coupling to the neighboring cells. The membrane potential across the plasma membrane is stabilized through gap junction coupling by lowering the input resistance. Thus, stored Ca2+ions are a key player in the maintenance of the cellular activity of neuroepithelial cells.

scholarly journals A Robust Single Primate Neuroepithelial Cell Clonal Expansion System for Neural Tube Development and Disease Studies

2016 ◽  
Vol 6 (2) ◽  
pp. 228-242 ◽  
Author(s):  
Xiaoqing Zhu ◽  
Bo Li ◽  
Zongyong Ai ◽  
Zheng Xiang ◽  
Kunshang Zhang ◽  
...  
Keyword(s):  
Neural Tube ◽  
Clonal Expansion ◽  
Neuroepithelial Cell ◽  
Expansion System ◽  
Neural Tube Development ◽  
Cell Clonal Expansion

Cell cycle and neuroepithelial cell shape during bending of the chick neural plate

1987 ◽  
Vol 218 (2) ◽  
pp. 196-206 ◽  
Author(s):  
Jodi L. Smith ◽  
Gary C. Schoenwolf
Keyword(s):  
Cell Cycle ◽  
Cell Shape ◽  
Neural Plate ◽  
Neuroepithelial Cell

Net1 (Neuroepithelial Cell Transforming Gene 1 Protein)

2012 ◽  
pp. 1199-1203
Author(s):  
Rüdiger Horstkorte ◽  
Bettina Büttner ◽  
Kaya Bork ◽  
Navdeep Sahota ◽  
Sarah Sabir ◽  
...  
Keyword(s):  
Neuroepithelial Cell ◽  
Cell Transforming ◽  
Transforming Gene
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