scholarly journals Anemia of Prematurity

2020 ◽  
Author(s):  
Keyword(s):  
Anemia Of Prematurity

Anemia of prematurity: how low is too low?

2021 ◽  
Author(s):  
Catherine C. Cibulskis ◽  
Akhil Maheshwari ◽  
Rakesh Rao ◽  
Amit M. Mathur
Keyword(s):  
Anemia Of Prematurity

scholarly journals Effect of Oral Erythropoietin in Prevention of Anemia of Prematurity

2018 ◽  
Vol 41 (2) ◽  
pp. 101-109
Author(s):  
Md Jamshed Alam ◽  
Md Kamrul Ahsan Khan ◽  
Nazmun Nahar ◽  
Sanjoy Kumer Dey ◽  
Md A Mannan ◽  
...  
Keyword(s):  
Birth Weight ◽  
Breast Milk ◽  
Blood Transfusion ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Control Group ◽  
Group Iii ◽  
Anemia Of Prematurity ◽  
The Mean ◽  
Group Ii

Introduction: Anemia of prematurity (AOP) is a common problem of very low birth weight babies. Blood transfusion is a necessity when it occurs in moderate to severe form putting the child in to the risk of transfusion related complications. Erythropoietin, a potent stimulator of hemopoesis is available in breast milk in good amount and absorbed intact under physiologic condition. In this background oral recombinant human erythropoietin (rhEPO) can be a useful alternative to its subcutaneous administration in prevention of AOP.Objective: To evaluate the efficacy of oral rhEPO in the prevention of AOP in very low birth weight (VLBW) neonates.Methods: This randomized controlled study conducted in the NICU of BSMMU over one year. Total 60 preterm (<34 weeks)VLBW (<1500g) infants were enrolled and randomly divided into Control (group-I), Oral (group-II) and Subcutaneous (group III). Experimental groups (group-II & group-III) received rhEPO 400 IU/Kg, 3 times weekly in oral and subcutaneous (S/C) route respectively and continued for 2 weeks (Total 6 doses). Therapy was initiated 14 days after birth when the baby achieved oral feeding of at least 50 ml/kg/day of breast milk. All infants received oral iron and folic acid supplementation up to 12 weeks of postnatal age. Transfusion data were recorded. Anthropometric and hematological assessments were done at 2, 4, 6 and 12 weeks of age.Results: Baseline clinical characteristics and hematological values were almost similar in all groups. Mean hemoglobin were 11.34±0.68gm/dl, 11.88±0.54gm/dl& 12.12±1.32 gm/dl, the mean hematocrit were 34.11±2.03%, 35.66±1.65% & 36.38±3.97% and the mean reticulocyte were 7.56±2.48%, 9.85±1.50% & 9.22±3.11% in the control, oral and subcutaneous group respectively and the differences are statistically significant (p<0.05).Weight gain was higher in the intervention group at 6 and 12 weeks follow up than the control group(p<0.05).Only 2 (5.25%) infants, one in each of the intervention groups required blood transfusion, compared to 6 (31.5%) infants in control group (p<0.01).Conclusion: Oral EPO is as good as subcutaneous use of EPO in stimulating erythropoesis, maintaining HCT and Hb at high level and is safe in preterm baby.Bangladesh J Child Health 2017; VOL 41 (2) :101-109

COMPARISON OF ORAL AND INTRAMUSCULAR ADMINISTRATION OF IRON FOR PREVENTiON OF THE LATE ANEMIA OF PREMATURE INFANTS

PEDIATRICS ◽  
1960 ◽  
Vol 26 (3) ◽  
pp. 375-386
Author(s):  
Anneliese L. Sitarz ◽  
James A. Wolff ◽  
Frederick H. Von Hofe
Keyword(s):  
Side Effects ◽  
Premature Infants ◽  
Intramuscular Administration ◽  
Anemia Of Prematurity

Intramuscular administration of iron, given at the time a weight of 2,100 grams is reached, is as effective as oral use of iron in the treatment of the late anemia of prematurity. No toxicity or untoward side effects were noted when iron was given intramuscularly in the manner and dosage described. Intramuscular administration of iron is preferred when follow-up of infants after discharge from the nursery is difficult. Where follow-up is assured, orally administered iron remains the treatment of choice. (See Addendum.)

HEMATOPOIESIS IN PREMATURE INFANTS WITH SPECIAL CONSIDERATION OF THE EFFECT OF IRON AND OF ANIMAL-PROTEIN FACTOR

PEDIATRICS ◽  
1955 ◽  
Vol 16 (6) ◽  
pp. 753-762
Author(s):  
James A. Wolff ◽  
Alice M. Goodfellow
Keyword(s):  
Premature Infants ◽  
Animal Protein ◽  
Iron Therapy ◽  
First Year ◽  
Protein Factor ◽  
Anemia Of Prematurity ◽  
Significant Difference ◽  
One Year ◽  
First Year Of Life ◽  
Weight Groups

Normal values in the first 3 months of life have been determined for hemoglobin, erythrocytes, reticulocytes, platelets, leukocytes and differential counts for premature infants with birth weights less than 1200 gm., and for those between 1200 and 1500 gm. at birth. No significant difference was found in the degree of depression of levels of hemoglobin and erythrocytes when values in the 2 weight groups were compared. Two reticulocyte peaks occur during the first 3 months of life. The first peak is present immediately after birth. The second peak, at about the eighth week, coincides with the occurrence of the greatest degree of anemia. Neither iron therapy nor treatment with animal-protein factor containing vitamin B12 and Aureomycin®, started before the end of the third week of life, had a statistically significant effect on the early phase of the anemia of prematurity. Untreated premature infants and those given animal-protein factor were anemic at the end of the first year of life. Subjects given iron therapy had normal hemoglobin values at one year of age. Blood transfusion is rarely necessary in the treatment of the anemia of prematurity.

Erythropoietin Therapy in Anemia of Prematurity

2002 ◽  
Vol 16 (1) ◽  
pp. 18-23
Author(s):  
Monica Kaushal ◽  
Rajiv Aggarwal
Keyword(s):  
Anemia Of Prematurity
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