scholarly journals Phosphatidylcholine Biosynthesis

2020 ◽  
Author(s):  
Keyword(s):  
Phosphatidylcholine Biosynthesis

scholarly journals Impaired Phosphatidylcholine Biosynthesis Reduces Atherosclerosis and Prevents Lipotoxic Cardiac Dysfunction in ApoE −/− Mice

2011 ◽  
Vol 108 (6) ◽  
pp. 686-694 ◽  
Author(s):  
Laura K. Cole ◽  
Vernon W. Dolinsky ◽  
Jason R.B. Dyck ◽  
Dennis E. Vance
Keyword(s):  
Cardiac Dysfunction ◽  
Phosphatidylcholine Biosynthesis

scholarly journals A phosphatidylinositol transfer protein controls the phosphatidylcholine content of yeast Golgi membranes

1994 ◽  
Vol 124 (3) ◽  
pp. 273-287 ◽  
Author(s):  
TP McGee ◽  
HB Skinner ◽  
EA Whitters ◽  
SA Henry ◽  
VA Bankaitis
Keyword(s):  
Protein Transport ◽  
Phospholipid Composition ◽  
Membrane Phospholipid ◽  
Secretory Function ◽  
Golgi Membrane ◽  
Transfer Protein ◽  
Golgi Membranes ◽  
Phosphatidylcholine Biosynthesis ◽  
Phosphatidylinositol Transfer

SEC14p is required for protein transport from the yeast Golgi complex. We describe a quantitative analysis of yeast bulk membrane and Golgi membrane phospholipid composition under conditions where Golgi secretory function has been uncoupled from its usual SEC14p requirement. The data demonstrate that SEC14p specifically functions to maintain a reduced phosphatidylcholine content in Golgi membranes and indicate that overproduction of SEC14p markedly reduces the apparent rate of phosphatidylcholine biosynthesis via the CDP-choline pathway in vivo. We suggest that SEC14p serves as a sensor of Golgi membrane phospholipid composition through which the activity of the CDP-choline pathway in Golgi membranes is regulated such that a phosphatidylcholine content that is compatible with the essential secretory function of these membranes is maintained.

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