scholarly journals RAD51 Gene

2020 ◽  
Author(s):  
Keyword(s):  
Rad51 Gene

RAD51 gene is associated with advanced age-related macular degeneration in Chinese population

2013 ◽  
Vol 46 (16-17) ◽  
pp. 1689-1693 ◽  
Author(s):  
Jie Zhou ◽  
Dan Wang ◽  
Junjun Zhang ◽  
Meixia Zhang ◽  
Fang Lu ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Chinese Population ◽  
Age Related Macular Degeneration ◽  
Advanced Age ◽  
Rad51 Gene ◽  
Age Related

Semidominant suppressors of Srs2 helicase mutations of Saccharomyces cerevisiae map in the RAD51 gene, whose sequence predicts a protein with similarities to procaryotic RecA proteins

1992 ◽  
Vol 12 (7) ◽  
pp. 3224-3234 ◽  
Author(s):  
A Aboussekhra ◽  
R Chanet ◽  
A Adjiri ◽  
F Fabre
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Gamma Ray ◽  
Genetic Recombination ◽  
Reca Protein ◽  
Radiation Sensitivity ◽  
Recombinational Repair ◽  
Lacz Gene ◽  
Sequence Comparisons ◽  
Rad51 Gene ◽  
Srs2 Helicase

Eleven suppressors of the radiation sensitivity of Saccharomyces cerevisiae diploids lacking the Srs2 helicase were analyzed and found to contain codominant mutations in the RAD51 gene known to be involved in recombinational repair and in genetic recombination. These mutant alleles confer an almost complete block in recombinational repair, as does deletion of RAD51, but heterozygous mutant alleles suppress the defects of srs2::LEU2 cells and are semidominant in Srs2+ cells. The results of this study are interpreted to mean that wild-type Rad51 protein binds to single-stranded DNA and that the semidominant mutations do not prevent this binding. The cloning and sequencing of RAD51 indicated that the gene encodes a predicted 400-amino-acid protein with a molecular mass of 43 kDa. Sequence comparisons revealed homologies to domains of Escherichia coli RecA protein predicted to be involved in DNA binding, ATP binding, and ATP hydrolysis. The expression of RAD51, measured with a RAD51-lacZ gene fusion, was found to be UV- and gamma-ray-inducible, with dose-dependent responses.

scholarly journals Targeted disruption of the Rad51 gene leads to lethality in embryonic mice.

1996 ◽  
Vol 93 (13) ◽  
pp. 6236-6240 ◽  
Author(s):  
T. Tsuzuki ◽  
Y. Fujii ◽  
K. Sakumi ◽  
Y. Tominaga ◽  
K. Nakao ◽  
...  
Keyword(s):  
Targeted Disruption ◽  
Rad51 Gene

scholarly journals Polymorphic Variants in 5′-UTR Regions of the RAD51 Gene are Associated With RAD51 Expression and Triple-Negative Breast Cancer (TNBC)

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Mohammad Al Hamad ◽  
Haitham Kussaibi ◽  
Khaled R. Alkharsah ◽  
Ahmed Alsayyah ◽  
Mohammed El Shawarby ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Rad51 Gene ◽  
Polymorphic Variants
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