Lipomatosis of Nerve

2020 ◽  
Author(s):  
Keyword(s):  
Lipomatosis Of Nerve

Response to the Letter to the Editor “Lipomatosis of nerve and overgrowth syndrome: an intriguing and still unclear correlation”

2019 ◽  
Vol 161 (6) ◽  
pp. 1087-1088
Author(s):  
Tomas Marek ◽  
Mark A. Mahan ◽  
Kimberly K. Amrami ◽  
Robert J. Spinner
Keyword(s):  
Overgrowth Syndrome ◽  
Letter To The Editor ◽  
Lipomatosis Of Nerve

Lipomatosis of Nerve

2014 ◽  
Vol 82 (3-4) ◽  
pp. 331-332 ◽  
Author(s):  
Chandan B. Mohanty ◽  
Rajiv Midha
Keyword(s):  
Lipomatosis Of Nerve

Strengthening the association of lipomatosis of nerve and nerve-territory overgrowth: a systematic review

2020 ◽  
Vol 132 (4) ◽  
pp. 1286-1294 ◽  
Author(s):  
Tomas Marek ◽  
Robert J. Spinner ◽  
Akshay Syal ◽  
Mark A. Mahan
Keyword(s):  
Systematic Review ◽  
Definite Diagnosis ◽  
Initial Screening ◽  
Sex Distribution ◽  
Comprehensive Review ◽  
Fibrolipomatous Hamartoma ◽  
Fibrotic Tissue ◽  
Lipomatosis Of Nerve ◽  
Probable Diagnosis ◽  
Definite Proof

OBJECTIVELipomatosis of nerve (LN) is a massive enlargement of a nerve due to abundant proliferation of adipose and fibrotic tissue within the epineurium—part of the spectrum of adipose lesions of nerves, including intra- and extraneural lipomas. LN has been frequently associated with soft-tissue and/or osseous overgrowth. Unfortunately, much confusion exists since many names have been used for LN (e.g., fibrolipomatous hamartoma, macrodystrophia lipomatosa, and so on). To better understand this condition and to evaluate its association with nerve-territory overgrowth, the authors attempted to compile the world’s literature on published LN cases.METHODSPubMed and Google Scholar databases were searched to identify published articles on LN cases, using a variety of terms. Publications in all languages were assessed. All publications with cases determined likely to be LN were read. Cases that provided clear clinicopathological and/or radiological evidence of LN were labeled as “definite” and cases that demonstrated features of LN (e.g., nerve-territory overgrowth) but lacked definite proof of nerve involvement were labeled as “probable.”RESULTSInitial screening revealed a total of 2465 papers. After exclusions, 281 publications reported cases with a definite diagnosis of LN and 120 articles reported cases with a probable diagnosis of LN. The authors identified 618 definite and 407 probable cases of LN. Sex distribution was balanced (51% female). Early diagnosis was common, with two-thirds of patients having symptoms in the 1st decade of life. The most commonly affected nerve was the median nerve (n = 391). Nerve-territory overgrowth was common (62% definite LN; 78% combined cases); overgrowth was exclusive to the territory of the affected nerve in all cases but 5.CONCLUSIONSThe authors present a comprehensive review and analysis of the literature of LN cases. One of the main findings was the nerve-territory overgrowth was associated with LN, especially when present earlier in life. The authors believe that all cases of LN associated with overgrowth can be explained on anatomical grounds, even in the few reported cases in which this is not immediately obvious.

Ultrasonographic Diagnosis of Lipomatosis of Nerve: A Review of Ultrasonographic Finding for 8 Cases

2020 ◽  
Vol 139 ◽  
pp. e730-e736
Author(s):  
Ping Xu ◽  
Bo Lu ◽  
He-Ping Deng ◽  
Ya-Ru Mi ◽  
Chun-Xia Yin ◽  
...  
Keyword(s):  
Ultrasonographic Diagnosis ◽  
Ultrasonographic Finding ◽  
Lipomatosis Of Nerve

Lipomatosis of nerve and overgrowth syndrome: an intriguing and still unclear correlation

2019 ◽  
Vol 161 (6) ◽  
pp. 1085-1086 ◽  
Author(s):  
Ignazio G. Vetrano ◽  
Luca Maria Sconfienza ◽  
Grazia Devigili ◽  
Vittoria Nazzi
Keyword(s):  
Overgrowth Syndrome ◽  
Lipomatosis Of Nerve

Lipomatosis of Nerve

2020 ◽  
pp. 499-500
Author(s):  
Simone Mocellin
Keyword(s):  
Lipomatosis Of Nerve

Adipose lesions of nerve: the need for a modified classification

2012 ◽  
Vol 116 (2) ◽  
pp. 418-431 ◽  
Author(s):  
Robert J. Spinner ◽  
Bernd W. Scheithauer ◽  
Kimberly K. Amrami ◽  
Doris E. Wenger ◽  
Marie-Noëlle Hébert-Blouin
Keyword(s):  
Literature Review ◽  
Classification System ◽  
Optimal Treatment ◽  
Conceptual Approach ◽  
Lipomatosis Of Nerve ◽  
Current Classification

Object Adipose lesions of nerve are rare and poorly understood. Their current classification, although not universally accepted, generally includes lipomatosis of nerve with or without localized macrodactyly, and intra- as well as extraneural lipoma. The authors believe that the spectrum of these lesions and their interrelationships are not currently appreciated. They propose an adaptation to the existing framework to illustrate the expanding spectrum of adipose lesions of nerve by considering lipomatosis and lipoma singly or in combination. Methods Fourteen representative cases are presented to demonstrate not only the intraneural and extraneural examples of lipomatosis and lipoma, but also their anatomical combinations. Results Based on the cases presented and a careful literature review, a conceptual approach to the classification of adipose lesions of nerve is generated. This approach incorporates the 2 essential lesions, lipomatosis of nerve and lipoma, in both their intra- and extraneural forms. This permits expansion to encompass combinations. Conclusions To press the concept that adipose tumors of nerve are a broad but interrelated spectrum of lesions, the authors propose modification of the present classification system. This approach provides an orderly platform for progress, reflects understanding of these interrelated lesions, and facilitates optimal treatment by distinguishing resectable from nonresectable components.

Lipomatosis of nerve and overgrowth: is there a preference for motor (mixed) vs. sensory nerve involvement?

2019 ◽  
Vol 161 (4) ◽  
pp. 679-684 ◽  
Author(s):  
Tomas Marek ◽  
Mark A. Mahan ◽  
Jodi M. Carter ◽  
Kimberly K. Amrami ◽  
Eduardo E. Benarroch ◽  
...  
Keyword(s):  
Sensory Nerve ◽  
Lipomatosis Of Nerve ◽  
Nerve Involvement

Segmental thoracic lipomatosis of nerve with nerve territory overgrowth

2014 ◽  
Vol 120 (5) ◽  
pp. 1118-1124 ◽  
Author(s):  
Mark A. Mahan ◽  
Kimberly K. Amrami ◽  
B. Matthew Howe ◽  
Robert J. Spinner
Keyword(s):  
Peripheral Nerves ◽  
Fatty Infiltration ◽  
Rare Condition ◽  
Spinal Nerves ◽  
Fibrolipomatous Hamartoma ◽  
Scoliotic Deformity ◽  
Lipomatosis Of Nerve ◽  
Thoracic Spinal ◽  
History Of ◽  
Hands And Feet

Lipomatosis of nerve (LN), or fibrolipomatous hamartoma, is a rare condition of fibrofatty enlargement of the peripheral nerves. It is associated with bony and soft tissue overgrowth in approximately one-third to two-thirds of cases. It most commonly affects the median nerve at the carpal tunnel or digital nerves in the hands and feet. The authors describe a patient with previously diagnosed hemihypertrophy of the trunk who had a history of large thoracic lipomas resected during infancy, a thoracic hump due to adipose proliferation within the thoracic paraspinal musculature, and scoliotic deformity. She had fatty infiltration in the thoracic spinal nerves on MRI, identical to findings pathognomonic of LN at better-known sites. Enlargement of the transverse processes at those levels and thickened ribs were also found. This case appears to be directly analogous to other instances of LN with overgrowth, except that this case involved axial nerves rather than the typical appendicular nerves.

A new pattern of lipomatosis of nerve: case report

2017 ◽  
Vol 126 (3) ◽  
pp. 933-937 ◽  
Author(s):  
Nikhil K. Prasad ◽  
Mark A. Mahan ◽  
Benjamin M. Howe ◽  
Kimberly K. Amrami ◽  
Robert J. Spinner
Keyword(s):  
Adipose Tissue ◽  
Case Report ◽  
Soft Tissue ◽  
Median Nerve ◽  
Peripheral Nerves ◽  
Full Spectrum ◽  
Spinal Nerves ◽  
Lipomatosis Of Nerve ◽  
Thoracic Spinal ◽  
Future Management

Lipomatosis of nerve (LN) is a rare disorder of peripheral nerves that produces proliferation of interfascicular adipose tissue. It may be associated with soft-tissue and bony overgrowth within the affected nerve territory. LN has been almost exclusively reported in appendicular peripheral nerves; the median nerve at the wrist and palm is among the most common locations. The authors present a new pattern of LN that shows circumferential proliferation of fat around the epineurium of the nerve. They believe that this case and the two other documented examples in the literature (also affecting cervical and thoracic spinal nerves) share the same new pattern of LN. Defining the full spectrum of adipose lesions of the nerve and establishing a cause-effect relationship with nerve-territory overgrowth disorders may offer options for future management through targeted nerve lesioning.

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