scholarly journals Vasopressin V1B Receptor

2020 ◽  
Author(s):  
Keyword(s):  
V1b Receptor

Evidence that atypical vasopressin V2 receptor in inner medulla of kidney is V1B receptor

2000 ◽  
Vol 401 (3) ◽  
pp. 289-296 ◽  
Author(s):  
Masayuki Saito ◽  
Atsuo Tahara ◽  
Toru Sugimoto ◽  
Kunitake Abe ◽  
Kiyoshi Furuichi
Keyword(s):  
Vasopressin V2 Receptor ◽  
V1b Receptor ◽  
V2 Receptor

Discovery of new lead for the design of antagonists of human vasopressin(VP)V1b receptor

2006 ◽  
pp. 641-642
Author(s):  
Sylvain Derick ◽  
Claude Barberis ◽  
Christophe Breton ◽  
Gilles Guillon ◽  
W.Y. Chan ◽  
...  
Keyword(s):  
V1b Receptor

Subcellular localization and internalization of the vasopressin V1B receptor

2015 ◽  
Vol 765 ◽  
pp. 291-299 ◽  
Author(s):  
Aki Kashiwazaki ◽  
Yoko Fujiwara ◽  
Hiroyoshi Tsuchiya ◽  
Nobuya Sakai ◽  
Katsushi Shibata ◽  
...  
Keyword(s):  
Subcellular Localization ◽  
V1b Receptor

Proinflammatory role of vasopressin through V1b receptors in hapten-induced experimental colitis in rodents: implication in IBD

2010 ◽  
Vol 299 (6) ◽  
pp. G1298-G1307 ◽  
Author(s):  
Laurent Ferrier ◽  
Claudine Serradeil-Le Gal ◽  
Anke M. Schulte ◽  
Valentina Vasina ◽  
Eric Gaultier ◽  
...  
Keyword(s):  
Mast Cell ◽  
Intestinal Inflammation ◽  
Experimental Colitis ◽  
Paracellular Permeability ◽  
Mast Cell Activation ◽  
Receptor Interaction ◽  
Trinitrobenzene Sulfonic Acid ◽  
Inflammatory Status ◽  
V1b Receptor

Vasopressin and its receptors modulate several gut functions, but their role in intestinal inflammation is unknown. Our aims were to determine 1) the localization of V1b receptors in human and rodent colon, 2) the role of vasopressin and V1b receptors in experimental colitis using two approaches: V1b−/− mice and a selective V1b receptor antagonist, SSR149415, and 3) the mechanisms involved. V1b receptors were localized in normal and inflamed colon from humans and rats. Experimental colitis was induced in rats and mice and some groups were treated before or after colitis induction with oral SSR149415 (3–30 mg/kg). Other groups of mice were submitted to dehydration to increase vasopressin plasma levels, prior to colitis induction. Body weight, damage scores, MPO, and TNF-α tissue levels were determined. Finally, colonic segments of wild-type (WT) and V1b−/− mice were mounted in Ussing chambers and paracellular permeability in response to vasopressin was studied. V1b receptors were expressed in enterocytes and ganglia cells of the enteric nervous system of human and rat intestine. Expression levels were independent from inflammatory status. Colitis was less severe in rodents treated by either preventive or curative SSR149415 and in V1b−/− mice. 2,4,6-Trinitrobenzene sulfonic acid induced a strong mortality in dehydrated animals that was reversed by preventive SSR149415 or mast cell stabilizer. Vasopressin significantly increased paracellular permeability in WT, but not in V1b−/− mice. Preincubation of colon tissues with SSR149415 abolished the vasopressin effect. Similarly, vasopressin had no effect in colonic preparations from WT mice pretreated with mast cell stabilizers. Vasopressin, through V1b receptor interaction, has proinflammatory properties linked to mast cell activation and downstream alterations of the colonic epithelial barrier. These findings underline the potential interest of V1b receptor blockers in gut inflammatory diseases.

Involvement of vasopressin V1b receptor in anti-anxiety action of SSRI and SNRI in mice

2010 ◽  
Vol 66 (3) ◽  
pp. 233-237 ◽  
Author(s):  
Yuta Ishizuka ◽  
Hiroshi Abe ◽  
Akito Tanoue ◽  
Hiroshi Kannan ◽  
Yasushi Ishida
Keyword(s):  
V1b Receptor
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