scholarly journals Apocrine Differentiation

2020 ◽  
Author(s):  
Author(s):  
S. E. Levine ◽  
A. D. Brinkhous ◽  
K. S. McCarty ◽  
J. A. Mossier ◽  
K.S. McCarty

A variant of ductal carcinoma of the human breast which has been designated apocrine carcinoma has distinctive light and electron microscopic features. Such tumors comprise approximately 0.5% of breast carcinomas. Abundant cytoplasmic membrane bound vesicles (400-600 nm) with dense homogeneous osmophilic cores characterize these tumors. These granules are also seen in apocrine metaplastic breast epithelial lesions1 and appear to be responsible for the finely granular eosinophilic cytoplasm observed by light microscopy. A high content of intermediate affinity non-saturable 4S progesteroneestrogen binding protein (PEBP) in apocrine carcinoma has been reported.2 The present ultrastructural study evaluates the presence of apocrine granules in infiltrating ductal carcinoma (NOS) to determine if a correlation exists between apocrine granule content and the quantity of PEBP present.


2015 ◽  
Vol 5 (9) ◽  
pp. 727-732
Author(s):  
P Vijayan ◽  
R Nayak

Background: Adnexal skin tumors are relatively rare and present diagnostic difficulties in view of the endless morphological spectrum, complex nomenclature and incomplete knowledge of their histogenesis. Since pathologists encounter these lesions rarely, accurate sub classification of these can be challenging. This study intends to study skin adnexal tumors with eccrine and apocrine differentiation with emphasis on their histomorphology.Materials and Methods:The present study is a five year retrospective study with comprehensive analysis of 40 cases of adnexal tumors of skin in a tertiary center in Karnataka, South India. These tumors were reclassified and subtyped according to WHO classification of skin tumors, 2006.Results and analysis:Out the 62 cases of adnexal tumors studied, 40 were tumors with eccrine and apocrine differentiation (77% benign and 23% malignant). Hidradenoma was the most common tumor comprising 37% of all tumors and 45% of the benign tumors followed byspiradenoma, cylindroma and chondroidsyringoma respectively. Head and neck region was the most common site of occurrence, and seventh decade was the most frequent age group of presentation. A definite female preponderance was noted. Pagets disease of the breast was the most common malignant tumor in this group comprising (10%). Conclusion: Histopathology is considered the gold standard in the diagnosis of these tumors and so a clear knowledge of the clinical presentation and histomorphology of these tumors is essential to make a correct diagnosis. A diagnostic logarithm based on histomorphology provides a logical approach in the subclassification of adnexal tumors.DOI:


1990 ◽  
Vol 62 (1) ◽  
pp. 113-117 ◽  
Author(s):  
NJ Bundred ◽  
RA Walker ◽  
D Everington ◽  
GK White ◽  
HJ Stewart ◽  
...  

2007 ◽  
Vol 12 (2) ◽  
pp. 55-60 ◽  
Author(s):  
Ingerlisa W. Mattoch ◽  
David S. Cassarino

1985 ◽  
Vol 5 (1) ◽  
pp. 67-73 ◽  
Author(s):  
W. R. Miller ◽  
J. Telford ◽  
J. M. Dixon ◽  
A. A. Shivas

2013 ◽  
Vol 53 (3) ◽  
pp. e234-e236 ◽  
Author(s):  
Takahiko Sakuma ◽  
Yukino Itou ◽  
Akitaka Shibata

1994 ◽  
Vol 425 (5) ◽  
Author(s):  
A. Pagani ◽  
A. Sapino ◽  
P. Bergnolo ◽  
G. Bussolati ◽  
V. Eusebi

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