scholarly journals Apocrine Differentiation

2020 ◽  
Author(s):  
Keyword(s):  
Apocrine Differentiation

Ultrastructural Study of Apocrine Differentiation in Human Mammary Carcinoma: Correlation of Granule Content With Sex Steroid Binding

1980 ◽  
Vol 38 ◽  
pp. 742-743
Author(s):  
S. E. Levine ◽  
A. D. Brinkhous ◽  
K. S. McCarty ◽  
J. A. Mossier ◽  
K.S. McCarty
Keyword(s):  
Ultrastructural Study ◽  
Ductal Carcinoma ◽  
Apocrine Carcinoma ◽  
Electron Microscopic ◽  
Granular Eosinophilic Cytoplasm ◽  
Eosinophilic Cytoplasm ◽  
Apocrine Differentiation ◽  
Microscopic Features ◽  
Membrane Bound ◽  
Epithelial Lesions

A variant of ductal carcinoma of the human breast which has been designated apocrine carcinoma has distinctive light and electron microscopic features. Such tumors comprise approximately 0.5% of breast carcinomas. Abundant cytoplasmic membrane bound vesicles (400-600 nm) with dense homogeneous osmophilic cores characterize these tumors. These granules are also seen in apocrine metaplastic breast epithelial lesions1 and appear to be responsible for the finely granular eosinophilic cytoplasm observed by light microscopy. A high content of intermediate affinity non-saturable 4S progesteroneestrogen binding protein (PEBP) in apocrine carcinoma has been reported.2 The present ultrastructural study evaluates the presence of apocrine granules in infiltrating ductal carcinoma (NOS) to determine if a correlation exists between apocrine granule content and the quantity of PEBP present.

scholarly journals Spectrum of skin adnexal tumors with eccrineand apocrine differentiation – A single institution study of 40 cases with clinicopathological correlation

2015 ◽  
Vol 5 (9) ◽  
pp. 727-732
Author(s):  
P Vijayan ◽  
R Nayak
Keyword(s):  
Correct Diagnosis ◽  
Neck Region ◽  
Skin Tumors ◽  
Benign Tumors ◽  
Head And Neck Region ◽  
Tertiary Center ◽  
Apocrine Differentiation ◽  
Diagnostic Difficulties ◽  
Adnexal Tumors

Background: Adnexal skin tumors are relatively rare and present diagnostic difficulties in view of the endless morphological spectrum, complex nomenclature and incomplete knowledge of their histogenesis. Since pathologists encounter these lesions rarely, accurate sub classification of these can be challenging. This study intends to study skin adnexal tumors with eccrine and apocrine differentiation with emphasis on their histomorphology.Materials and Methods:The present study is a five year retrospective study with comprehensive analysis of 40 cases of adnexal tumors of skin in a tertiary center in Karnataka, South India. These tumors were reclassified and subtyped according to WHO classification of skin tumors, 2006.Results and analysis:Out the 62 cases of adnexal tumors studied, 40 were tumors with eccrine and apocrine differentiation (77% benign and 23% malignant). Hidradenoma was the most common tumor comprising 37% of all tumors and 45% of the benign tumors followed byspiradenoma, cylindroma and chondroidsyringoma respectively. Head and neck region was the most common site of occurrence, and seventh decade was the most frequent age group of presentation. A definite female preponderance was noted. Pagets disease of the breast was the most common malignant tumor in this group comprising (10%). Conclusion: Histopathology is considered the gold standard in the diagnosis of these tumors and so a clear knowledge of the clinical presentation and histomorphology of these tumors is essential to make a correct diagnosis. A diagnostic logarithm based on histomorphology provides a logical approach in the subclassification of adnexal tumors.DOI:

scholarly journals Is apocrine differentiation in breast carcinoma of prognostic significance?

1990 ◽  
Vol 62 (1) ◽  
pp. 113-117 ◽  
Author(s):  
NJ Bundred ◽  
RA Walker ◽  
D Everington ◽  
GK White ◽  
HJ Stewart ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Prognostic Significance ◽  
Apocrine Differentiation

Cutaneous Adnexal Neoplasms With Eccrine or Apocrine Differentiation

2007 ◽  
Vol 12 (2) ◽  
pp. 55-60 ◽  
Author(s):  
Ingerlisa W. Mattoch ◽  
David S. Cassarino
Keyword(s):  
Apocrine Differentiation

Androgen metabolism and apocrine differentiation in human breast cancer

1985 ◽  
Vol 5 (1) ◽  
pp. 67-73 ◽  
Author(s):  
W. R. Miller ◽  
J. Telford ◽  
J. M. Dixon ◽  
A. A. Shivas
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Androgen Metabolism ◽  
Apocrine Differentiation

Large pedunculated poroma with apocrine differentiation

2013 ◽  
Vol 53 (3) ◽  
pp. e234-e236 ◽  
Author(s):  
Takahiko Sakuma ◽  
Yukino Itou ◽  
Akitaka Shibata
Keyword(s):  
Apocrine Differentiation

PIP/GCDFP-15 gene expression and apocrine differentiation in carcinomas of the breast

1994 ◽  
Vol 425 (5) ◽  
Author(s):  
A. Pagani ◽  
A. Sapino ◽  
P. Bergnolo ◽  
G. Bussolati ◽  
V. Eusebi
Keyword(s):  
Gene Expression ◽  
Apocrine Differentiation
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