scholarly journals CYP2A6 Gene

2020 ◽  
Author(s):  
Keyword(s):  
Cyp2a6 Gene

Associations of CYP2A6 Gene Polymorphism with Smoking Status Among Jordanians: Gender-Related Differences

2019 ◽  
Vol 20 (9) ◽  
pp. 765-770 ◽  
Author(s):  
Hana M. Hammad ◽  
Amer Imraish ◽  
Belal Azab ◽  
Al M. Best ◽  
Yousef S. Khader ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Genetic Polymorphism ◽  
Smoking Status ◽  
Hepatic Enzyme ◽  
Nicotine Metabolism ◽  
Significant Frequency ◽  
Cytochrome P450 2A6 ◽  
Study Population ◽  
Major Metabolic Pathway ◽  
Cyp2a6 Gene

Background: Cytochrome P450 2A6 enzyme (CYP2A6), an essential hepatic enzyme involved in the metabolism of drugs, is responsible for a major metabolic pathway of nicotine. Variation in the activity of polymorphic CYP2A6 alleles has been implicated in inter-individual differences in nicotine metabolism. Aims: The objective of the current study was to assess the association between the smoking status and the cytochrome P450 2A6 enzyme (CYP2A6) genotype in Jordanians. Methods: In the current study, 218 (117 Male and 101 female) healthy unrelated Jordanian volunteers were recruited. CYP2A6*1B, CYP2A6*4 and CYP2A6*9 were determined and correlated with subject smoking status. Results: *1A/*1A was the most common genetic polymorphism in the overall study population, with no significant frequency differences between smokers and non-smokers. When the population was divided according to gender, only male smokers showed a significant correlation between genotype and smoking status. Considering the CYP2A6*9 genotype, the results showed differences in distribution between smokers and non-smokers, but only women showed a significant association between CYP2A6*9 allele genotype and smoking status. Conclusion: The results of this study show that there is a significant association between CYP2A6*9 genotype and smoking status. They also show that CYP2A6 genotype is significantly influenced by gender.

Low frequency of CYP2A6 gene polymorphism as revealed by a one-step polymerase chain reaction method

1999 ◽  
Vol 9 (3) ◽  
pp. 327-332 ◽  
Author(s):  
Gen-Fu Chen ◽  
Yong-Ming Tang ◽  
Bridgett Green ◽  
Dong-Xin Lin ◽  
F. Peter Guengerich ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Gene Polymorphism ◽  
Low Frequency ◽  
Polymerase Chain Reaction Method ◽  
Chain Reaction ◽  
Reaction Method ◽  
One Step ◽  
Polymerase Chain ◽  
Cyp2a6 Gene ◽  
Step Polymerase Chain Reaction

A novel mutant allele of the CYP2A6 gene (CYP2A6*11) found in a cancer patient who showed poor metabolic phenotype towards tegafur

2002 ◽  
Vol 12 (4) ◽  
pp. 299-306 ◽  
Author(s):  
Satoshi Daigo ◽  
Yoshiki Takahashi ◽  
Masaki Fujieda ◽  
Noritaka Ariyoshi ◽  
Hiroshi Yamazaki ◽  
...  
Keyword(s):  
Cancer Patient ◽  
Mutant Allele ◽  
Metabolic Phenotype ◽  
Cyp2a6 Gene

Novel Mutations of the CYP2A6 Gene in a Thai Population with Lowered Capacity of Coumarin 7-Hydroxylation

2002 ◽  
Vol 17 (2) ◽  
pp. 161-163 ◽  
Author(s):  
Kazuma Kiyotani ◽  
Hiroshi Yamazaki ◽  
Masaki Fujieda ◽  
Satoshi Daigo ◽  
Soisungwan Satarug ◽  
...  
Keyword(s):  
Novel Mutations ◽  
Thai Population ◽  
Coumarin 7 ◽  
Cyp2a6 Gene

scholarly journals The Effects of CYP2A6 Gene Polymorphism on Cardiovascular Diseases

2021 ◽  
Vol 10 (3) ◽  
pp. 217-233
Author(s):  
Preiffer A. Prasojo ◽  
Christine Patramurti
Keyword(s):  
Insulin Resistance ◽  
Nervous System ◽  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Gene Polymorphism ◽  
Blood Levels ◽  
Nicotine Metabolism ◽  
Exclusion Criteria ◽  
Sympathetic Nervous ◽  
Cyp2a6 Gene

The CYP2A6 gene encodes its enzymes and is highly polymorphic, leading to variations in allele forms, both in the active and inactive states. These changes result in a decrease, increase or deletion of enzyme activities. One of the specific substrates is nicotine, an active compound in cigarettes. Nicotine is a major risk factor for cardiovascular diseases, and the inactive alleles tends to decrease its metabolism and expands the threat to infections. Therefore, this study aims to evaluate the effects of CYP2A6gene polymorphism on cardiovascular diseases. Relevant literatures were obtained using PubMed and Google Scholar, while the eventual selection followed the inclusion and exclusion criteria. Based on this review, the CYP2A6 gene polymorphism, both in increased, decreased or deleted alleles, was known to significantly influence nicotine metabolism and its blood levels. Species categorized as slow or poor metabolizers, tend to decrease the nicotine metabolism, but result in greater nicotine blood levels. This outcome subsequently accelerated the activation of the sympathetic nervous system, lipolysis, and insulin resistance, to trigger atherosclerosis. In summary, CYP2A6 gene polymorphism is known to increase cardiovascular diseases, particularly among active or passive smokers.

scholarly journals The Role of CYP2A6 Genetic Polymorphism in Nicotine Dependence and Tobacco Consumption among Bataknese Male Smokers

2018 ◽  
Vol 6 (5) ◽  
pp. 864-866 ◽  
Author(s):  
Noni Novisari Soeroso ◽  
Rozaimah Zain-Hamid ◽  
Bintang Y. M. Sinaga ◽  
Ahmad Hamim Sadewa ◽  
Tamsil Syafiuddin ◽  
...  
Keyword(s):  
Nicotine Dependence ◽  
Tobacco Consumption ◽  
Cross Sectional Study ◽  
Cigarette Consumption ◽  
Research Subjects ◽  
Cross Sectional ◽  
The Relationship ◽  
Very High ◽  
Cyp2a6 Gene

AIM: This research aimed to analyse the relationship between CYP2A6 gene polymorphism with nicotine dependence and its relation to the number of cigarette consumption among Bataknese smokers.METHOD: This study was a cross-sectional study involving 140 research subjects in Medan, Indonesia.RESULTS: Nicotine dependence rates were found to be significantly associated with the number of cigarette consumption expressed in the Brinkman Index.CONCLUSION: The *1A wild-type alleles have a greater risk of high-very high dependence rate compared to the other variants.

Association of CYP2A6 gene polymorphisms with cigarette consumption: A meta-analysis

2015 ◽  
Vol 149 ◽  
pp. 268-271 ◽  
Author(s):  
Lulu Pan ◽  
Xiaorong Yang ◽  
Suyun Li ◽  
Chongqi Jia
Keyword(s):  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Cigarette Consumption ◽  
Cyp2a6 Gene
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