scholarly journals Trilateral Retinoblastoma

2020 ◽  
Author(s):  
Keyword(s):  
Trilateral Retinoblastoma

Trilateral Retinoblastoma: Ectopic Intracranial Retinoblastoma Associated with Bilateral Retinoblastoma

1982 ◽  
Vol 19 (6) ◽  
pp. 320-325
Author(s):  
Lorenz E Zimmerman ◽  
Robert P Burns ◽  
Gerald Wankum ◽  
Richard Tully ◽  
James A Esterly
Keyword(s):  
Bilateral Retinoblastoma ◽  
Trilateral Retinoblastoma

Trilateral retinoblastoma: ocular and pineal retinoblastomas

1985 ◽  
Vol 63 (3) ◽  
pp. 367-370 ◽  
Author(s):  
Dennis L. Johnson ◽  
Roma Chandra ◽  
Wink S. Fisher ◽  
M. Kathryn Hammock ◽  
Craig A. McKeown
Keyword(s):  
Host Resistance ◽  
Early Mortality ◽  
Early Age ◽  
Pineal Tumor ◽  
Multicentric Occurrence ◽  
Content Type ◽  
Aggressive Management ◽  
Bilateral Retinoblastoma ◽  
Trilateral Retinoblastoma ◽  
Germinal Mutation

✓ Trilateral retinoblastomas, the syndrome of bilateral retinoblastoma associated with ectopic retinoblastoma in the pineal gland, is rare but well recognized. In contrast to bilateral retinoblastomas alone, the ocular retinoblastomas in trilateral retinoblastoma develop before the age of 6 months, and a family history positive for retinoblastoma is usually obtained. The retinal tumors are often quiescent at the time that the pineal tumor is discovered, and show no evidence of metastatic spread after enucleation of the globes. Pathologically, the pineal tumor is indistinguishable from the ocular retinoblastoma. The pathophysiology of this syndrome is not well understood, but a germinal mutation is thought to target photoreceptor tissue for further postzygotic mutation. Eventual expression depends on the inherited host resistance to the carcinogenic manifestation of these genes. The low host resistance of trilateral retinoblastoma is evident by the early age of presentation, the multicentric occurrence of the tumor, and the high early mortality rate despite aggressive management.

Abstract 958: Improving survival of extraocular, metastatic and trilateral retinoblastoma patients with combined intensive therapy.

2013 ◽  
Author(s):  
Helen SL Chan ◽  
Elise Héon ◽  
Tal Schechter ◽  
Helen Dimaras ◽  
Brenda L. Gallie ◽  
...  
Keyword(s):  
Intensive Therapy ◽  
Trilateral Retinoblastoma

scholarly journals Orbital Pseudocellulitis: A Retinoblastoma-Associated Masquerade Syndrome

2020 ◽  
Vol 6 (6) ◽  
pp. 430-437
Author(s):  
Francesco Martino ◽  
Maria Chiara Gelmi ◽  
Paolo Galluzzi ◽  
Sonia De Francesco ◽  
Clelia Miracco ◽  
...  
Keyword(s):  
Case Series ◽  
Orbital Cellulitis ◽  
Resonance Imaging ◽  
Imaging Studies ◽  
Tissue Edema ◽  
Trilateral Retinoblastoma ◽  
Neoplastic Process ◽  
Masquerade Syndrome ◽  
Fellow Eyes ◽  
Ophthalmoscopic Examination

<b><i>Introduction:</i></b> A masquerade syndrome is an atypical presentation of a neoplastic process that mimics an inflammatory condition. In this paper, we focus on orbital pseudocellulitis. <b><i>Case Series:</i></b> Our case series includes 5 retinoblastoma patients with orbital pseudocellulitis at presentation. In 3 patients the disease was bilateral, in 1 trilateral, and in 1 unilateral. The eyes with pseudocellulitis were enucleated, while the fellow eyes were treated conservatively, when affected. Four patients responded well to the therapy and showed remission of the tumor. The patient with trilateral retinoblastoma did not respond to therapy and died of disease. <b><i>Discussion:</i></b> Differential diagnosis with infectious orbital cellulitis is extremely important. Patients with orbital cellulitis present with fever, sinusitis, leukocytosis, and raised inflammatory markers, while ophthalmoscopic examination is negative and imaging studies show sinus involvement. On the contrary, patients with retinoblastoma do not show systemic inflammation, while ophthalmoscopic examination reveals leukocoria, buphthalmos, and an intraocular tumor mass associated with retinal detachment. Magnetic resonance imaging shows intralesional calcifications and soft tissue edema without sinus involvement. Histology confirms the diagnosis. <b><i>Conclusions:</i></b> Medical history, physical examination, and imaging studies are crucial in the diagnosis of retinoblastoma-associated orbital pseudocellulitis. Retinoblastoma should be excluded in all patients with signs of pre-septal orbital cellulitis through fundoscopy and/or imaging studies

scholarly journals Trilateral Retinoblastoma: A Case Report

2002 ◽  
Vol 17 (1) ◽  
pp. 137 ◽  
Author(s):  
Eun Yoon Cho ◽  
Yeon Lim Suh ◽  
Hyung Jin Shin
Keyword(s):  
Case Report ◽  
Trilateral Retinoblastoma

scholarly journals The Incidence of Trilateral Retinoblastoma: A Systematic Review and Meta-Analysis

2015 ◽  
Vol 160 (6) ◽  
pp. 1116-1126.e5 ◽  
Author(s):  
Marcus C. de Jong ◽  
Wijnanda A. Kors ◽  
Pim de Graaf ◽  
Jonas A. Castelijns ◽  
Annette C. Moll ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Trilateral Retinoblastoma
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