scholarly journals Patient Table Relationship

2020 ◽  
Author(s):  
Keyword(s):  
Patient Table

Leveraging machine learning technology to efficiently identify and match patients for precision oncology clinical trials.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e13588-e13588
Author(s):  
Laura Sachse ◽  
Smriti Dasari ◽  
Marc Ackermann ◽  
Emily Patnaude ◽  
Stephanie OLeary ◽  
...  
Keyword(s):  
Machine Learning ◽  
Clinical Trials ◽  
Language Processing ◽  
Time Trial ◽  
High Fidelity ◽  
Learning Technology ◽  
Precision Oncology ◽  
Sequencing Data ◽  
Clinical Criteria ◽  
Patient Table

e13588 Background: Pre-screening for clinical trials is becoming more challenging as inclusion/exclusion criteria becomes increasingly complex. Oncology precision medicine provides an exciting opportunity to simplify this process and quickly match patients with trials by leveraging machine learning technology. The Tempus TIME Trial site network matches patients to relevant, open, and recruiting clinical trials, personalized to each patient’s clinical and molecular biology. Methods: Tempus screens patients at sites within the TIME Trial Network to find high-fidelity matches to clinical trials. The patient records include documentation submitted alongside NGS orders as well as electronic medical records (EMR) ingested through EMR Integrations. While Tempus-sequenced patients were automatically matched to trials using a Tempus-built matching application, EMR records were run through a natural language processing (NLP) data abstraction model to identify patients with an actionable gene of interest. Structured data were analyzed to filter to patients that lack a deceased date and have an encounter date within a predefined time period. Tempus abstractors manually validated the resulting unstructured records to ensure each patient was matched to a TIME Trial at a site capable of running the trial. For all high-level patient matches, a Tempus Clinical Navigator manually evaluated other clinical criteria to confirm trial matches and communicated with the site about trial options. Results: Patient matching was accelerated by implementing NLP gene and report detection (which isolated 17% of records) and manual screening. As a result, Tempus facilitated screening of over 190,000 patients efficiently using proprietary NLP technology to match 332 patients to 21 unique interventional clinical trials since program launch. Tempus continues to optimize its NLP models to increase high-fidelity trial matching at scale. Conclusions: The TIME Trial Network is an evolving, dynamic program that efficiently matches patients with clinical trial sites using both EMR and Tempus sequencing data. Here, we show how machine learning technology can be utilized to efficiently identify and recruit patients to clinical trials, thereby personalizing trial enrollment for each patient.[Table: see text]

scholarly journals HDR brachytherapy and supervoltage external beam therapy of cervical cancer: Protection of the intestinal tract during the treatment

2002 ◽  
Vol 10 (1) ◽  
pp. 13-17 ◽  
Author(s):  
Sasa Ljubenkovic
Keyword(s):  
Small Bowel ◽  
Standard Technique ◽  
Acute Radiation ◽  
Watery Diarrhoea ◽  
Radiation Enteritis ◽  
High Dose ◽  
Non Invasive ◽  
Dose Volume ◽  
Patient Table ◽  
One Year

BACKGROUND: During radiotherapy in most of the irradiated patients occur the symptoms of acute radiation enteritis, less frequently cystitis or proctitis. The aim of this work was to apply non invasive exclusion methods to reduce the small bowel volume within the pelvic high dose volume and indirectly to reduce the number and severity of acute radiation enteritis METHODS: A total number of 183 patients were enrolled in our prospective randomised investigation we performed at the Clinic of Oncology in Knez Selo during one year. Ninety patients from E-group were irradiated with the standard technique two opposite parallel fields on the Mevatron-7445 linear accelerator (SIEMENS) patient-table, while 93 from C-group were irradiated under special conditions on our unique patient-table (PT) manufactured at our special demands by the Jugorendgen Ei-Ni? factory Brachytherapy was administered with RALT technique in both groups with isotope machine BUCHLER. RESULTS: Individual application of exclusion techniques led to protection of over 50% of the small bowel (118-1065 cm3) in 30/43 (70%) patients, and even in 10/43 (23%) more than 90% of the small bowel was protected (118-835 cm3), which would otherwise be irradiated with conventional techniques. None of the patients from E-group (out of 90) had more than 8 stools a day (G3), while in C-group there were 20 such cases Seventy-seven percent of the patients from E-group had formed stool, while the percent in C-group was 29. In C-group 40% of the patients had so called "watery stools"; in E-group the percent was 4. Out of 53 patients from K-group with mobile small bowel, 21 (40%) had "watery diarrhoea". CONCLUSION: Measures to prevent radiation enteritis should be taken before (surgical) or during (non invasive) radiotherapy. At the Clinic of Oncology in Knez Selo, individual application of small bowel exclusion techniques using the unique patient-table (JUGORENDGEN Ei-Ni?) led to protection of the small bowel during radiotherapy of uterine malignancies, which was reflected in a significantly reduced number and severity of acute enteritis symptoms.

Impact of flexible body surface coil and patient table on PET quantification and image quality in integrated PET/MR

2014 ◽  
Vol 53 (03) ◽  
pp. 79-87 ◽  
Author(s):  
M. Souvatzoglou ◽  
A. Martinez-Möller ◽  
M. Schwaiger ◽  
S. I. Ziegler ◽  
S. Fürst ◽  
...  
Keyword(s):  
Standard Deviation ◽  
Image Quality ◽  
Image Noise ◽  
Ct Scanner ◽  
Patient Study ◽  
Surface Coils ◽  
Scan Time ◽  
Pet Ct ◽  
Relative Standard ◽  
Patient Table

SummaryThe surface coils of the Biograph mMR integrated PET/MR system were optimised for PET, but are otherwise unaccounted for. The patient table is still more massive than those of PET/CT devices. The goal was to assess those hardware effects on quantification, count statistics, image quality and scan time both with phantoms and in patients and to investigate their clinical relevance. Patients, material, methods: PET phantom data were acquired with and without the patient table. Image noise was expressed as relative standard deviation and compared to a state-of-the-art PET/CT scanner. Protocols of the phantom/patient study regarding the surface coils were similar. Thoraces/ab- domens of 11 patients were scanned with and without a coil (1 BP, 4 min). Mean uptake and standard deviation in a cubical VOI were derived and expressed as SUV. Results: The patient table reduced the number of true coincidences (trues) by 19% (PET/MR) and by 11% (PET/CT). The scan duration for the mMR had to be increased by approximately 30% to achieve a noise level comparable to that of the PET/CT. Decreased SUVs with coil observed in the phantom were confirmed by the patient study. By removing the coil, the mean liver SUV increased by (6 ± 2)%. With (+3 ± 14)%, the average change was similar in lesions, but exceeded 20% in almost one fifth of them. The number of trues grew by (6 ± 1)% for the patients and by 7% for the phantom. Conclusion: Due to the additional attenuation caused by MR hardware, PET scan durations would have to be increased compared to current PET/CTs to provide similar image noise levels. The effect of the coils is mostly in the order of statistical fluctuations. In tumour lesions, it is more pronounced and shows a larger variability. Therefore, coils should be included in the attenuation correction to ensure accurate quantification and thus comparability across PET/MR and PET/CT scanners and within patient populations.

Real-Time Patient Table Removal in CT Images

2016 ◽  
pp. 1-8
Author(s):  
Luming Chen ◽  
Shibin Wu ◽  
Zhicheng Zhang ◽  
Shaode Yu ◽  
Yaoqin Xie ◽  
...  
Keyword(s):  
Real Time ◽  
Ct Images ◽  
Patient Table

SU-E-I-55: The Contribution to Skin Dose Due to Scatter From the Patient Table and the Head Holder During Fluoroscopy

2015 ◽  
Vol 42 (6Part6) ◽  
pp. 3254-3254 ◽  
Author(s):  
N Islam ◽  
Z Xiong ◽  
S Vijayan ◽  
S Rudin ◽  
D Bednarek
Keyword(s):  
Skin Dose ◽  
Head Holder ◽  
Patient Table

scholarly journals 2493. Real-World Utilization of Ibalizumab (IBA) Without an Optimized Background Regimen (OBT)

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S865-S865 ◽  
Author(s):  
Jeannette Bouchard ◽  
Caroline Derrick ◽  
Joseph Horvath
Keyword(s):  
Real World ◽  
Active Agent ◽  
Multidrug Resistant ◽  
Phase Iii ◽  
Hiv Virus ◽  
Oral Agents ◽  
Patient Table ◽  
Tenofovir Alafenamide ◽  
High Level ◽  
Level Resistance

Abstract Background It is difficult to treat multidrug-resistant (MDR) human immunodeficiency virus (HIV). Trogarzo® (ibalizumab) a novel monoclonal antibody was approved in 2018 for heavily treatment-experienced HIV patients. Data support IBA use with at least one fully active agent, an OBR. Real-world IBA data are lacking. We report a successful case of reaching and maintaining suppression with IBA in a patient without an OBR. Methods Mutations were reviewed for the patient, Table 1, and evaluated for treatment. The patient is a 52- year old male, diagnosed in 1994, with MDR HIV secondary to non-adherence. Upon re-presenting to care, the patient was non-compliant with ART. Genotypic interpretation via the Stanford/ANRS algorithm was performed and interpreted, resulting in the addition of IBA intravenous administration every other week. IBA was obtained through patient assistance and costs were covered by the institution for infusion. Results Evaluation of the resistance profile indicated varying resistance to all available ART. More specifically, high-level resistance to all FDA-approved INSTIs, PIs, and low to high-level resistance to all NNRTIs and NRTIs. Table 2 outlines the ART history and viral load (VL) trends. The patient was initiated on daruanvir/ritonavir twice daily, etravirine twice daily, emtricitabine/tenofovir alafenamide and did not reach suppression. IBA was added off-label to a failing regimen. The patient reached VS (VL < 200 copies/mL) at Week 4 and has had an undetectable VL for 8 weeks. Notably his CD4 count has risen to 46, first detectable number since re-presenting to care. Conclusion We describe a heavily treatment experienced patient with an MDR HIV virus who achieved an undetectable VL without an OBT and the addition of intravenous IBA. Fostemsavir, was utilized in IBA’s phase III trial for similar patients, however, it is not currently FDA-approved nor available. Further data are needed to ensure continued susceptibility to IBA without an OBT. This patient required high-level coordination to reach each visit and receive this therapy alongside his oral agents. We conclude, IBA has allowed this patient to reach and maintain VS. Disclosures All authors: No reported disclosures.

A comparison of the efficacy of multiple ultraviolet light room decontamination devices in a radiology procedure room

2019 ◽  
Vol 40 (2) ◽  
pp. 158-163 ◽  
Author(s):  
Jennifer L. Cadnum ◽  
Annette L. Jencson ◽  
Scott A. Gestrich ◽  
Scott H. Livingston ◽  
Boris A. Karaman ◽  
...  
Keyword(s):  
Uv Light ◽  
Low Pressure ◽  
Laboratory Evaluation ◽  
Table Analysis ◽  
Patient Table ◽  
Set Up ◽  
Time Required ◽  
Cleaning And Disinfection ◽  
Uv C ◽  
Procedure Room

AbstractObjectiveTo evaluate the efficacy of multiple ultraviolet (UV) light decontamination devices in a radiology procedure room.DesignLaboratory evaluation.MethodsWe compared the efficacy of 8 UV decontamination devices with a 4-minute UV exposure time in reducing recovery of methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), and Clostridium difficile spores on steel disk carriers placed at 5 sites on a computed tomography patient table. Analysis of variance was used to compare reductions for the different devices. A spectrometer was used to obtain irradiance measurements for the devices.ResultsFour standard vertical tower low-pressure mercury devices achieved 2 log10CFU or greater reductions in VRE and MRSA and ~1 log10CFU reductions in C. difficile spores, whereas a pulsed-xenon device resulted in less reduction in the pathogens (P<.001). In comparison to the vertical tower low-pressure mercury devices, equal or greater reductions in the pathogens were achieved by 3 nonstandard low-pressure mercury devices that included either adjustable bulbs that could be oriented directly over the exam table, a robotic base allowing movement along the side of the table during operation, or 3 vertical towers operated simultaneously. The low-pressure mercury devices produced primarily UV-C light, whereas the pulsed-xenon device produced primarily UV-A and UV-B light. The time required to move the devices from the corner of the room and set up for operation varied from 18 to 59 seconds.ConclusionsMany currently available UV devices could provide an effective and efficient adjunct to manual cleaning and disinfection in radiology procedure rooms.

Detecting hereditary nonpolyposis colorectal cancer syndrome (HNPCC) in patients with colorectal cancer (CRC): Optimal strategies at lower costs.

2012 ◽  
Vol 30 (4_suppl) ◽  
pp. 396-396 ◽  
Author(s):  
Daniel Erik Abbott ◽  
Scott B. Cantor ◽  
Miguel A. Rodriguez-Bigas ◽  
George J. Chang ◽  
Patrick M Lynch ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Optimal Strategies ◽  
Cost Effective ◽  
Cancer Syndrome ◽  
Dna Mismatch ◽  
Testing Strategies ◽  
Hereditary Nonpolyposis ◽  
Protein Expressions ◽  
Patient Table ◽  
List Prices

396 Background: The optimal strategy to detect HNPCC in CRC pts remains controversial, and may include testing tumors for microsatellite (MSI) status and/or pts for mutations in DNA mismatch repair (MMR) genes. Costs of 6 testing strategies were compared against their risks of missing pt managed as HNPCC. Methods: 185 consecutive CRCs were prospectively tested by both immunohistochemistry (IHC, for protein expressions of MLH1, MSH2, MSH6, PMS2) and PCR-based MSI. Secondary tests included MLH1 promoter methylation, BRAF mutation, and germline mutation, as appropriate. A decision tree compared the strategy of performing both IHC and MSI in all (Strategy 1) to five alternatives (Strategies 2-6, Table ). Costs were obtained from commercial list prices, Medicare reimbursement, and literature; probabilities were calculated from pt data. Incremental cost-effectiveness ratios (ICERs) were reported for each additional pt managed as HNPCC Results: 20 (10.8%) pts were identified as being managed as HNPCC. Performing IHC and MSI in all (Strategy 1) or IHC first in all followed by MSI when IHC was normal (Strategy 4) detected all 20 cases. When compared to performing IHC only (Strategy 2), Strategy 4 demonstrated an ICER of $31,821 per additional case detected, while other strategies were more costly and/or less effective (Table). Between the two strategies that detected all cases of HNPCC, Strategy 4 was less costly ($1,049 vs $1,098 per patient, Table). Conclusions: When combined with appropriate secondary and confirmatory testing, performing IHC and MSI in all or IHC in all followed by MSI when IHC were normal, both showed a zero miss rate, while the latter was slightly more cost-effective. [Table: see text]

scholarly journals Heart rate monitoring in ultra-high-field MRI using frequency information obtained from video signals of the human skin compared to electrocardiography and pulse oximetry

2015 ◽  
Vol 1 (1) ◽  
pp. 69-72 ◽  
Author(s):  
Nicolai Spicher ◽  
Stefan Maderwald ◽  
Mark E. Ladd ◽  
Markus Kukuk
Keyword(s):  
Heart Rate ◽  
Pulse Oximetry ◽  
Human Skin ◽  
High Field ◽  
7 Tesla ◽  
Contactless Method ◽  
Heart Rate Monitoring ◽  
Ultra High Field ◽  
Heart Rates ◽  
Patient Table

AbstractVideos of the human skin contain subtle color variations associated with the blood volume pulse. This remote photoplethysmography signal can be used for heart rate monitoring and represents an alternative to signals obtained from contact-based hardware. We developed an algorithm that estimates the heart rate in real-time from photoplethysmography signals and evaluate its performance in the context of ultra-high-field magnetic resonance imaging. We compare its accuracy to heart rate values estimated from electrocardiography and finger pulse oximetry triggers, obtained from MR vendor-provided hardware. For eight subjects, two experiments are conducted with the patient table outside and inside a 7 Tesla scanner. During both 5 min setups, heart rates from the algorithm and contact-based methods are stored. Their comparison suggests technical feasibility of the contactless method but that it is inferior in accuracy compared to contact-based hardware and that low heart rates (≤50 beats per minute) and adequate illumination are major challenges for practical feasibility.

Sign in / Sign up

Export Citation Format

Share Document