scholarly journals Androstenediol Metabolite Measurement

2020 ◽  
Author(s):  
Keyword(s):  
Metabolite Measurement

Clinical experience of optimising thiopurine use through metabolite measurement in inflammatory bowel disease

2018 ◽  
Vol 41 (10) ◽  
pp. 629-635
Author(s):  
Eugenia Sánchez Rodríguez ◽  
Raquel Ríos León ◽  
Francisco Mesonero Gismero ◽  
Agustín Albillos ◽  
Antonio Lopez-Sanroman
Keyword(s):  
Inflammatory Bowel Disease ◽  
Clinical Experience ◽  
Bowel Disease ◽  
Inflammatory Bowel ◽  
Metabolite Measurement

scholarly journals Metabolite Measurement: Pitfalls to Avoid and Practices to Follow

2017 ◽  
Vol 86 (1) ◽  
pp. 277-304 ◽  
Author(s):  
Wenyun Lu ◽  
Xiaoyang Su ◽  
Matthias S. Klein ◽  
Ian A. Lewis ◽  
Oliver Fiehn ◽  
...  
Keyword(s):  
Metabolite Measurement

scholarly journals Vitamin D in Follicular Fluid Correlates With the Euploid Status of Blastocysts in a Vitamin D Deficient Population

2021 ◽  
Vol 11 ◽  
Author(s):  
Ana Arnanz ◽  
Neelke De Munck ◽  
Ibrahim El Khatib ◽  
Aşina Bayram ◽  
Andrea Abdala ◽  
...  
Keyword(s):  
Vitamin D ◽  
Follicular Fluid ◽  
Serum Levels ◽  
Human Reproduction ◽  
Serum Samples ◽  
Preimplantation Genetic Testing ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Metabolite Measurement ◽  
Deficient Group

ContextThe widespread distribution of the Vitamin D (VitD) receptor in reproductive tissues suggests an important role for VitD in human reproduction. The assessment of patient´s VitD is based on the 25-hydroxyvitamin D (25(OH)D) metabolite measurement. However, most of the circulating 25(OH)D is bound to either VitD-binding protein (VDBP) (88%) or albumin (12%) and less than 1% circulates free.ObjectiveTo determine a possible correlation between VitD levels in serum (S) and follicular fluid (FF) and blastocyst ploidy status in patients undergoing infertility treatment.MethodsA prospective observational study was performed including couples planned for preimplantation genetic testing for aneuploidies (PGT-A) from ART Fertility Clinics. Patients were classified according to their 25(OH)D-Serum levels: VitD deficient group <20 ng/ml and insufficient/replete ≥20 ng/ml defined as VitD non-deficient group.ResultsSerum samples and 226 FF from individual follicles were collected for 25(OH)D, bioavailable 25(OH)D, free 25(OH)D, and % free 25(OH)D measurement. 25(OH)D-Serum in VitD deficient and non-deficient were 13.2±4.0 ng/ml vs 32.3±9.2 ng/ml; p<0.001. FF from 40 and 74 biopsied blastocysts was analysed of which 52.5 and 60.8% were euploid (p = 0.428), respectively. In VitD deficient patients, mean 25(OH)D-FF, bioavailable 25(OH)D-FF, and free 25(OH)D-FF were higher in euploid vs aneuploid blastocysts (18.3±6.3 ng/ml vs 13.9±4.8 ng/ml; p = 0.040; 1.5±0.5 ng/ml vs 1.1±0.4 ng/ml; p = 0.015; 0.005±0.002 ng/ml vs 0.003±0.001 ng/ml; p = 0.023, respectively), whilst no differences were found in VitD non-deficient patients (37.9±12.3 ng/ml vs 40.6±13.7 ng/ml; p = 0.380; 3.1±1.1 ng/ml vs 3.3±1.2 ng/ml; p = 0.323; 0.01±0.003 ng/ml vs 0.01±0.004 ng/ml; p = 0.319, respectively).ConclusionVitD non-deficient patients have a significantly higher probability of obtaining a euploid blastocyst compared to VitD deficient patients (OR:33.36, p = 0.002).

Role of thiopurine metabolite measurement in the management of autoimmune hepatitis

Gut ◽  
2012 ◽  
Vol 61 (10) ◽  
pp. 1515.1-1515
Author(s):  
Safa Al-Shamma ◽  
Simon McLaughlin ◽  
Raymond McCrudden ◽  
Sean Weaver ◽  
Earl Williams
Keyword(s):  
Autoimmune Hepatitis ◽  
Metabolite Measurement

P3-249: Magnetic Resonance Spectroscopy Based Metabolite Measurement Differentiates Alzheimer's From Healthy Brain

2016 ◽  
Vol 12 ◽  
pp. P924-P924
Author(s):  
Nasim Sheikh-Bahaei ◽  
Seyed Ahmad Sajjadi ◽  
Roido Manavaki ◽  
Mary McLean ◽  
John T. O'Brien ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
Metabolite Measurement
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