scholarly journals Siewert Type III

2020 ◽  
Author(s):  
Keyword(s):  
Siewert Type ◽  
Type Iii ◽  
Siewert Type Iii

scholarly journals Survival Benefit of Pyloric Lymph Node Dissection for Siewert Type II/III Adenocarcinoma of the Esophagogastric Junction Based on Tumor Diameter: A Large Cohort Study

2021 ◽  
Vol 11 ◽  
Author(s):  
Xia Lin ◽  
Zhengyan Li ◽  
Chenjun Tan ◽  
Xiaoshuang Ye ◽  
Jie Xiong ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Esophagogastric Junction ◽  
Tumor Diameter ◽  
Type Ii ◽  
Node Dissection ◽  
Siewert Type ◽  
Siewert Type Ii ◽  
Type Iii ◽  
Siewert Type Iii

BackgroundIt is unclear whether the dissection of pyloric lymph nodes (PLNs, No. 5 and No. 6 lymph nodes) is necessary for adenocarcinoma of the esophagogastric junction (AEG) with a tumor diameter >4 cm based on current guidelines. This study aimed at evaluating whether pyloric node lymphadenectomy is essential for patients with Siewert type II/III AEG according to different tumor diameters.MethodsThis study included 300 patients on whom transabdominal total gastrectomy was performed for Siewert type II/III AEG at a high-volume center in China from January 2006 to December 2015. The index of estimated benefit from lymph node dissection (IEBLD) was used to analyze the priority of pyloric lymphadenectomy.ResultsIn Siewert type II AEG, the 5-year overall survival (OS) and the 5-year disease-free survival (DFS) were similar between patients with PLN-positive cancer and patients of stage III AEG without PLN metastasis (23.1% vs. 30.6%, p = 0.505; 23.1% vs. 27.1%, p = 0.678). However, in Siewert type III AEG, the OS and the DFS of patients with PLN-positive cancer were significantly lower than that of patients with stage III without PLN metastasis (7.9% vs. 27.8%, p = 0.021; 0 vs. 26.8%, p = 0.005). According to the IEBLD, the dissection of PLNs did not appear to be beneficial in either Siewert type II AEG or type III AEG, whereas a stratified analysis revealed that PLN dissection yielded a high therapeutic benefit for Siewert type II AEG with tumor diameters >4 cm.ConclusionWe recommended that the PLNs be dissected in Siewert type II AEG when a tumor diameter is >4 cm. Total gastrectomy should be optional for Siewert type II AEG with a tumor diameter >4 cm and Siewert type III AEG.

scholarly journals Surgical treatment of tumors of the proximal stomach with involvement of the distal esophagus: A 26-year experience with Siewert type III tumors

2006 ◽  
Vol 132 (4) ◽  
pp. 755-762.e1 ◽  
Author(s):  
K. Robert Shen ◽  
Stephen D. Cassivi ◽  
Claude Deschamps ◽  
Mark S. Allen ◽  
Francis C. Nichols ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Distal Esophagus ◽  
Proximal Stomach ◽  
Siewert Type ◽  
Type Iii ◽  
Siewert Type Iii

scholarly journals The optimal extent of lymph node dissection for adenocarcinoma of the esophagogastric junction differs between Siewert type II and Siewert type III patients

2014 ◽  
Vol 18 (2) ◽  
pp. 375-381 ◽  
Author(s):  
Hironobu Goto ◽  
Masanori Tokunaga ◽  
Yuichiro Miki ◽  
Rie Makuuchi ◽  
Norihiko Sugisawa ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Dissection ◽  
Esophagogastric Junction ◽  
Type Ii ◽  
Node Dissection ◽  
Siewert Type ◽  
Siewert Type Ii ◽  
Type Iii ◽  
Siewert Type Iii

Lower Mediastinal Lymph Node Metastasis is an Independent Survival Factor of Siewert Type II and III Adenocarcinomas in the Gastroesophageal Junction

2012 ◽  
Vol 78 (5) ◽  
pp. 567-573 ◽  
Author(s):  
Masaki Nakamura ◽  
Makoto Iwahashi ◽  
Mikihito Nakamori ◽  
Teiji Naka ◽  
Toshiyasu Ojima ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Mediastinal Lymph Node ◽  
Type Ii ◽  
Mediastinal Lymph Node Metastasis ◽  
Siewert Type ◽  
Survival Factors ◽  
Siewert Type Ii ◽  
Type Iii ◽  
Node Metastasis

We examined clinicopathological features and surgical outcomes in patients with adenocarcinoma in the gastroesophageal junction (GEJ), while also analyzing the survival factors that have a prognostic impact. Between 1991 and 2009, 61 patients with tumors in the GEJ (Siewert type II and III) underwent primary surgical resection. Thirty of 61 patients had type II tumors (49.2%) and 31 had type III tumors (50.8%). The tumor size was larger in type III tumors than type II tumors ( P = 0.0026). The overall 5-year survival rates in patients with type II tumors and type III tumors were 44.2 per cent and 41.4 per cent, respectively, with no significant differences ( P = 0.1888). The independent survival factors were lower mediastinal lymph node metastasis ( P = 0.0323) and a noncurative resection ( P = 0.0442). The independent survival factors for patients who underwent curative resections were the tumor size ( P = 0.0422), M category ( P = 0.0489), and lower mediastinal lymph node metastasis ( P = 0.0482). This study showed lower mediastinal lymph node metastasis to be an independent survival factor, and also suggested that lower mediastinal lymph node metastasis was associated with distant metastasis in patients with adenocarcinoma in the GEJ (Siewert type II and III). Therefore, the preoperative early detection of such metastasis is important to improve patient survival.

Long-term survival in 101 metastatic gastroesophageal cancer (mGEAC) patients eventually treated with consolidative local therapy.

2017 ◽  
Vol 35 (4_suppl) ◽  
pp. 197-197
Author(s):  
Dilsa Mizrak Kaya ◽  
Xuemei Wang ◽  
Kazuto Harada ◽  
Mariela A. Blum Murphy ◽  
Prajnan Das ◽  
...  
Keyword(s):  
Clinical Course ◽  
Local Therapy ◽  
Decision Making Process ◽  
Gastroesophageal Cancer ◽  
Tumor Treatment ◽  
Term Survival ◽  
Siewert Type ◽  
Primary Location ◽  
Siewert Type Iii

197 Background: Through a multidisciplinary decision-making process, we developed a strategy of systemic therapy followed by local consolidative therapy (chemoradiation and/or surgery) for selected mGEAC patients. We present results in a large cohort. Methods: From our database, we identified a 101 such patients. We analyzed the association of various clinical variables (location of primary, location of metastases, duration of initial chemotherapy, histologic grade, and radiation dose {≥50.4 Gy vs. <50.4 Gy}) with overall survival (OS). Results: There were 71 patients with proximal primary (esophageal, Siewert types I/II) and 30 patients with distal primary (Siewert type III and gastric). The median OS was 25.7 months (95% CI: 22.3-32.8 months). The OS rates at 2-years and 5-years from diagnosis were 53.8% (95% CI: 44.7%-64.8%) and 20.7% (95% CI: 13.4%-31.9%), respectively. The median OS was highly associated with the location of primary (22.8 months for proximal GEACs vs. 41.5 months for distal GEACs, p=0.03). Duration of initial chemotherapy was highly associated with OS (21.8 months for <3 months vs. 32.5 months for ≥3 months, p=0.004). Association between OS and tumor/treatment characteristics. Conclusions: Selected patients with mGEAC (who have favorable clinical course) can have up to 20% 5-year survival with this strategy. Patients with distal GEAC and those who receive initial chemotherapy for longer time are the maximum beneficiaries. [Table: see text]

scholarly journals Prognostic Significance of the Proximal Margin for Esophagogastric Junction Adenocarcinoma With Type II and III Tumors After Surgery

2020 ◽  
Author(s):  
Qian Yan ◽  
Weixian Hu ◽  
Jiabin Zheng ◽  
Zejian Lv ◽  
Junjiang Wang ◽  
...  
Keyword(s):  
Overall Survival ◽  
Esophagogastric Junction ◽  
Median Number ◽  
Type Ii ◽  
Proximal Margin ◽  
Tumor Patients ◽  
Optimal Length ◽  
Siewert Type ◽  
Type Iii ◽  
Esophagogastric Junction Adenocarcinoma

Abstract BackgroundThe incidence of esophagogastric junction adenocarcinoma (EJA) has increased in recent years, with surgical resection the main choice of treatment. The optimal length of the proximal margin for EJA is still under debate, and the impact of EJA survival and recurrence remains unclear. The aim of the present study was to investigate the influence of the optimal length of the proximal margin on EJA.MethodsFrom January 2011 to December 2015, 131 patients who had EJA with type II tumors were included and retrospectively analyzed. All patients underwent radical R0 resection. The proximal margin was measured promptly after resection, and the frozen-section pathological examination was negative for the margin.ResultsThere were 3 cases of Siewert type I EJA (2.9 %), 75 cases of Siewert type II EJA (57.9 %), and 53 cases (40.1%) of Siewert type III EJA. The median number of lymph nodes examined was 19 (range: 1–41), and the median number of positive lymph nodes was 2 (range: 0–18). Sixty-three patients underwent total gastrectomy (48.1%), and 68 underwent proximal gastrectomy (51.9%). The median follow-up time was 57.3 months: (range 1.9–174.1); 34 patients (26%) relapsed and 74 (56.5%) died. The 5-year overall survival rate of type II tumor patients was 68.2%, and that of type III tumor patients was 38.5% (P = 0.02). For patients with a proximal margin <2 cm, the median recurrence time was 41.6 months, whereas it was for 42.8 months for patients with proximal margin >2 cm (log–rank: 0.496). Our data analysis found that a proximal margin length of 2 cm was a prognostic variable for type II and type III tumors.ConclusionsThere are a number of factors associated with recurrence and overall survival at 5 years for patients who have EJA with type II and type III tumors, and a proximal margin >2 cm may indicate better prognosis.

Some Observations on Changes in Denervated Taste Buds of Circumvallate Papillae of Rabbits

1969 ◽  
Vol 27 ◽  
pp. 308-309
Author(s):  
Sunao Fujimoto ◽  
Raymond G. Murray ◽  
Assia Murray
Keyword(s):  
Taste Buds ◽  
Taste Bud ◽  
Cell Type ◽  
Dark Cells ◽  
Type Iii ◽  
Circumvallate Papillae ◽  
Taste Bud Cells ◽  
Light Cells

Taste bud cells in circumvallate papillae of rabbit have been classified into three groups: dark cells; light cells; and type III cells. Unilateral section of the 9th nerve distal to the petrosal ganglion was performed in 18 animals, and changes of each cell type in the denervated buds were observed from 6 hours to 10 days after the operation.Degeneration of nerves is evident at 12 hours (Fig. 1) and by 2 days, nerves are completely lacking in the buds. Invasion by leucocytes into the buds is remarkable from 6 to 12 hours but then decreases. Their extrusion through the pore is seen. Shrinkage and disturbance in arrangement of cells in the buds can be seen at 2 days. Degenerated buds consisting of a few irregular cells and remnants of degenerated cells are present at 4 days, but buds apparently normal except for the loss of nerve elements are still present at 6 days.

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