scholarly journals Neutrophil Collagenase

2020 ◽  
Author(s):  
Keyword(s):  
Neutrophil Collagenase

scholarly journals Modulation of the Catalytic Activity of Neutrophil Collagenase MMP-8 on Bovine Collagen I

2002 ◽  
Vol 277 (26) ◽  
pp. 23123-23130 ◽  
Author(s):  
Magda Gioia ◽  
Giovanni Francesco Fasciglione ◽  
Stefano Marini ◽  
Silvana D'Alessio ◽  
Giampiero De Sanctis ◽  
...  
Keyword(s):  
Catalytic Activity ◽  
Collagen I ◽  
Bovine Collagen ◽  
Neutrophil Collagenase

scholarly journals Cleavage of Native Cartilage Aggrecan by Neutrophil Collagenase (MMP-8) Is Distinct from Endogenous Cleavage by Aggrecanase

1997 ◽  
Vol 272 (14) ◽  
pp. 9294-9299 ◽  
Author(s):  
Elizabeth C. Arner ◽  
Carl P. Decicco ◽  
Robert Cherney ◽  
Micky D. Tortorella
Keyword(s):  
Native Cartilage ◽  
Neutrophil Collagenase

scholarly journals Growth factor independence-1 (Gfi-1) plays a role in mediating specific granule deficiency (SGD) in a patient lacking a gene-inactivating mutation in the C/EBPϵ gene

Blood ◽  
2007 ◽  
Vol 109 (10) ◽  
pp. 4181-4190 ◽  
Author(s):  
Arati Khanna-Gupta ◽  
Hong Sun ◽  
Theresa Zibello ◽  
Han Myung Lee ◽  
Richard Dahl ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transcriptional Repression ◽  
Bacterial Infections ◽  
Heterozygous Mutation ◽  
Positive Role ◽  
Rare Congenital Disorder ◽  
Neutrophil Collagenase ◽  
Blood Neutrophils ◽  
Specific Granule ◽  
Inactivating Mutation

Abstract Neutrophil-specific granule deficiency (SGD) is a rare congenital disorder marked by recurrent bacterial infections. Neutrophils from SGD patients lack secondary and tertiary granules and their content proteins and lack normal neutrophil functions. Gene-inactivating mutations in the C/EBPϵ gene have been identified in 2 SGD patients. Our studies on a third SGD patient revealed a heterozygous mutation in the C/EBPϵ gene. However, we demonstrate elevated levels of C/EBPϵ and PU.1 proteins in the patient's peripheral blood neutrophils. The expression of the transcription factor growth factor independence-1 (Gfi-1), however, was found to be markedly reduced in our SGD patient despite the absence of an obvious mutation in this gene. This may explain the elevated levels of both C/EBPϵ and PU.1, which are targets of Gfi-1 transcriptional repression. We have generated a growth factor–dependent EML cell line from the bone marrow of Gfi-1+/− and Gfi-1+/+ mice as a model for Gfi-1–deficient SGD, and demonstrate that lower levels of Gfi-1 expression in the Gfi-1+/− EML cells is associated with reduced levels of secondary granule protein (SGP) gene expression. Furthermore, we demonstrate a positive role for Gfi-1 in SGP expression, in that Gfi-1 binds to and up-regulates the promoter of neutrophil collagenase (an SGP gene), in cooperation with wild-type but not with mutant C/EBPϵ. We hypothesize that decreased Gfi-1 levels in our SGD patient, together with the mutant C/EBPϵ, block SGP expression, thereby contributing to the underlying etiology of the disease in our patient.

scholarly journals Expression of Neutrophil Collagenase (Matrix Metalloproteinase-8) in Human Atheroma

Circulation ◽  
2001 ◽  
Vol 104 (16) ◽  
pp. 1899-1904 ◽  
Author(s):  
Michael P. Herman ◽  
Galina K. Sukhova ◽  
Peter Libby ◽  
Norbert Gerdes ◽  
Nga Tang ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Neutrophil Collagenase ◽  
Human Atheroma

Activation of neutrophil collagenase by cathepsin G

Inflammation ◽  
1989 ◽  
Vol 13 (3) ◽  
pp. 245-258 ◽  
Author(s):  
Constance Capodici ◽  
Geetha Muthukumaran ◽  
Marie A. Amoruso ◽  
Richard A. Berg
Keyword(s):  
Cathepsin G ◽  
Neutrophil Collagenase

Human Neutrophil Collagenase (MMP-8), Identified in Bronchiectasis BAL Fluid, Correlates With Severity of Disease

CHEST Journal ◽  
1995 ◽  
Vol 107 (6) ◽  
pp. 1641-1647 ◽  
Author(s):  
Ruth Sepper ◽  
Yrjö T. Konttinen ◽  
Yangli Ding ◽  
Michiaki Takagi ◽  
Timo Sorsa
Keyword(s):  
Human Neutrophil ◽  
Severity Of Disease ◽  
Neutrophil Collagenase ◽  
Human Neutrophil Collagenase

Susceptibility of Type I Collagen Containing Mutated α1(1) Chains to Cleavage by Human Neutrophil Collagenase

Matrix ◽  
1993 ◽  
Vol 13 (3) ◽  
pp. 181-186 ◽  
Author(s):  
Karen A. Hasty ◽  
Hong Wu ◽  
Michael Byrne ◽  
Mary B. Goldring ◽  
Jerome M. Seyer ◽  
...  
Keyword(s):  
Human Neutrophil ◽  
Type I Collagen ◽  
Type I ◽  
Neutrophil Collagenase ◽  
Human Neutrophil Collagenase
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