scholarly journals CDKN1A Gene

2020 ◽  
Author(s):  
Keyword(s):  
2009 ◽  
Vol 284 (12) ◽  
pp. 8073-8082 ◽  
Author(s):  
Anna Saramäki ◽  
Sarah Diermeier ◽  
Ruth Kellner ◽  
Heidi Laitinen ◽  
Sami Vaïsänen ◽  
...  

2003 ◽  
Vol 350 (2) ◽  
pp. 73-76 ◽  
Author(s):  
Robert H. Ring ◽  
Zuzana Valo ◽  
Chunguang Gao ◽  
Michael E. Barish ◽  
Judith Singer-Sam

Tumor Biology ◽  
2016 ◽  
Vol 37 (8) ◽  
pp. 10469-10478 ◽  
Author(s):  
Sandra Liliana Vargas-Torres ◽  
Elyzabeth Avvad Portari ◽  
Amanda Lima Silva ◽  
Evandro Mendes Klumb ◽  
Heloísa Carneiro da Rocha Guillobel ◽  
...  

2020 ◽  
Vol 40 (9) ◽  
pp. 4979-4987
Author(s):  
DENISA HRCKOVA DROZDKOVA ◽  
JAN GURSKY ◽  
JIRI MINARIK ◽  
IVO ÜBERALL ◽  
ZDENEK KOLAR ◽  
...  

2019 ◽  
Vol 19 (4) ◽  
pp. 575-585 ◽  
Author(s):  
Joanna Zyla ◽  
Sylwia Kabacik ◽  
Grainne O’Brien ◽  
Salma Wakil ◽  
Najla Al-Harbi ◽  
...  

Aging ◽  
2009 ◽  
Vol 1 (5) ◽  
pp. 470-480 ◽  
Author(s):  
Silvia Gravina ◽  
Francesco Lescai ◽  
Gregory Hurteau ◽  
Graham J. Brock ◽  
Anna Saramaki ◽  
...  

2015 ◽  
Vol 35 (9) ◽  
pp. 1633-1647 ◽  
Author(s):  
Eros Di Giorgio ◽  
Enrico Gagliostro ◽  
Andrea Clocchiatti ◽  
Claudio Brancolini

MEF2s are pleiotropic transcription factors (TFs) which supervise multiple cellular activities. During the cell cycle, MEF2s are activated at the G0/G1transition to orchestrate the expression of the immediate early genes in response to growth factor stimulation. Here we show that, in human and murine fibroblasts, MEF2 activities are downregulated during late G1. MEF2C and MEF2D interact with the E3 ligase F-box protein SKP2, which mediates their subsequent degradation through the ubiquitin-proteasome system. The cyclin-dependent kinase 4 (CDK4)/cyclin D1 complex phosphorylates MEF2D on serine residues 98 and 110, and phosphorylation of these residues is an important determinant for SKP2 binding. Unscheduled MEF2 transcription during the cell cycle reduces cell proliferation, whereas its containment sustains DNA replication. The CDK inhibitor p21/CDKN1A gene is a MEF2 target gene required to exert this antiproliferative influence. MEF2C and MEF2D bind a region within the first intron ofCDKN1A, presenting epigenetic markers of open chromatin. Importantly, H3K27 acetylation within this regulative region depends on the presence of MEF2D. We propose that following the initial engagement in the G0/G1transition, MEF2C and MEF2D must be polyubiquitylated and degraded during G1progression to diminish the transcription of theCDKN1Agene, thus favoring entry into S phase.


Biomarkers ◽  
2010 ◽  
Vol 16 (1) ◽  
pp. 42-50 ◽  
Author(s):  
Maria Lina Tornesello ◽  
Luigi Buonaguro ◽  
Medea Cristillo ◽  
Bennon Biryahwaho ◽  
Robert Downing ◽  
...  

2019 ◽  
Author(s):  
Yiqun Zhang ◽  
Lanlan Zhou ◽  
Shengliang Zhang ◽  
Marie D. Ralff ◽  
Shuai Zhao ◽  
...  

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