CDKN1A Gene | ScienceGate

Cyclical Chromatin Looping and Transcription Factor Association on the Regulatory Regions of the p21 (CDKN1A) Gene in Response to 1α,25-Dihydroxyvitamin D3

Journal of Biological Chemistry ◽

10.1074/jbc.m808090200 ◽

2009 ◽

Vol 284 (12) ◽

pp. 8073-8082 ◽

Cited By ~ 82

Author(s):

Anna Saramäki ◽

Sarah Diermeier ◽

Ruth Kellner ◽

Heidi Laitinen ◽

Sami Vaïsänen ◽

...

Keyword(s):

Transcription Factor ◽

Regulatory Regions ◽

Dihydroxyvitamin D3 ◽

Chromatin Looping ◽

Cdkn1a Gene

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The Cdkn1a gene (p21Waf1/Cip1) is an inflammatory response gene in the mouse central nervous system

Neuroscience Letters ◽

10.1016/s0304-3940(03)00883-8 ◽

2003 ◽

Vol 350 (2) ◽

pp. 73-76 ◽

Cited By ~ 12

Author(s):

Robert H. Ring ◽

Zuzana Valo ◽

Chunguang Gao ◽

Michael E. Barish ◽

Judith Singer-Sam

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Inflammatory Response ◽

Response Gene ◽

Cdkn1a Gene ◽

Mouse Central Nervous System

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Roles of CDKN1A gene polymorphisms (rs1801270 and rs1059234) in the development of cervical neoplasia

Tumor Biology ◽

10.1007/s13277-016-4850-3 ◽

2016 ◽

Vol 37 (8) ◽

pp. 10469-10478 ◽

Cited By ~ 7

Author(s):

Sandra Liliana Vargas-Torres ◽

Elyzabeth Avvad Portari ◽

Amanda Lima Silva ◽

Evandro Mendes Klumb ◽

Heloísa Carneiro da Rocha Guillobel ◽

...

Keyword(s):

Gene Polymorphisms ◽

Cervical Neoplasia ◽

Cdkn1a Gene

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CDKN1A Gene Expression in Two Multiple Myeloma Cell Lines With Different P53 Functionality

Anticancer Research ◽

10.21873/anticanres.14501 ◽

2020 ◽

Vol 40 (9) ◽

pp. 4979-4987

Author(s):

DENISA HRCKOVA DROZDKOVA ◽

JAN GURSKY ◽

JIRI MINARIK ◽

IVO ÜBERALL ◽

ZDENEK KOLAR ◽

...

Keyword(s):

Gene Expression ◽

Multiple Myeloma ◽

Cell Lines ◽

Myeloma Cell ◽

Multiple Myeloma Cell ◽

Cdkn1a Gene

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Combining CDKN1A gene expression and genome-wide SNPs in a twin cohort to gain insight into the heritability of individual radiosensitivity

Functional & Integrative Genomics ◽

10.1007/s10142-019-00658-3 ◽

2019 ◽

Vol 19 (4) ◽

pp. 575-585 ◽

Cited By ~ 3

Author(s):

Joanna Zyla ◽

Sylwia Kabacik ◽

Grainne O’Brien ◽

Salma Wakil ◽

Najla Al-Harbi ◽

...

Keyword(s):

Gene Expression ◽

Individual Radiosensitivity ◽

Genome Wide ◽

Insight Into ◽

Cdkn1a Gene

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Identification of single nucleotide polymorphisms in the p21 (CDKN1A) gene and correlations with longevity in the Italian population

Aging ◽

10.18632/aging.100041 ◽

2009 ◽

Vol 1 (5) ◽

pp. 470-480 ◽

Cited By ~ 26

Author(s):

Silvia Gravina ◽

Francesco Lescai ◽

Gregory Hurteau ◽

Graham J. Brock ◽

Anna Saramaki ◽

...

Keyword(s):

Single Nucleotide Polymorphisms ◽

Italian Population ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Cdkn1a Gene

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The Control Operated by the Cell Cycle Machinery on MEF2 Stability Contributes to the Downregulation of CDKN1A and Entry into S Phase

Molecular and Cellular Biology ◽

10.1128/mcb.01461-14 ◽

2015 ◽

Vol 35 (9) ◽

pp. 1633-1647 ◽

Cited By ~ 30

Author(s):

Eros Di Giorgio ◽

Enrico Gagliostro ◽

Andrea Clocchiatti ◽

Claudio Brancolini

Keyword(s):

Cell Cycle ◽

Ubiquitin Proteasome System ◽

S Phase ◽

Open Chromatin ◽

Cyclin Dependent Kinase ◽

Murine Fibroblasts ◽

Subsequent Degradation ◽

Ubiquitin Proteasome ◽

F Box Protein ◽

Cdkn1a Gene

MEF2s are pleiotropic transcription factors (TFs) which supervise multiple cellular activities. During the cell cycle, MEF2s are activated at the G0/G1transition to orchestrate the expression of the immediate early genes in response to growth factor stimulation. Here we show that, in human and murine fibroblasts, MEF2 activities are downregulated during late G1. MEF2C and MEF2D interact with the E3 ligase F-box protein SKP2, which mediates their subsequent degradation through the ubiquitin-proteasome system. The cyclin-dependent kinase 4 (CDK4)/cyclin D1 complex phosphorylates MEF2D on serine residues 98 and 110, and phosphorylation of these residues is an important determinant for SKP2 binding. Unscheduled MEF2 transcription during the cell cycle reduces cell proliferation, whereas its containment sustains DNA replication. The CDK inhibitor p21/CDKN1A gene is a MEF2 target gene required to exert this antiproliferative influence. MEF2C and MEF2D bind a region within the first intron ofCDKN1A, presenting epigenetic markers of open chromatin. Importantly, H3K27 acetylation within this regulative region depends on the presence of MEF2D. We propose that following the initial engagement in the G0/G1transition, MEF2C and MEF2D must be polyubiquitylated and degraded during G1progression to diminish the transcription of theCDKN1Agene, thus favoring entry into S phase.

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