scholarly journals NPR1 Gene

2020 ◽  
Author(s):  
Keyword(s):  
2012 ◽  
Vol 22 (2) ◽  
pp. 359-368 ◽  
Author(s):  
Vinod Kumar ◽  
Sameer G. Joshi ◽  
Alois A. Bell ◽  
Keerti S. Rathore

2006 ◽  
Vol 143 (2) ◽  
pp. 838-848 ◽  
Author(s):  
Il-Pyung Ahn ◽  
Soonok Kim ◽  
Yong-Hwan Lee ◽  
Seok-Cheol Suh

Cell ◽  
1997 ◽  
Vol 88 (1) ◽  
pp. 57-63 ◽  
Author(s):  
Hui Cao ◽  
Jane Glazebrook ◽  
Joseph D Clarke ◽  
Sigrid Volko ◽  
Xinnian Dong

2010 ◽  
Vol 298 (1) ◽  
pp. F103-F108 ◽  
Author(s):  
Di Zhao ◽  
Kailash N. Pandey ◽  
L. Gabriel Navar

Atrial natriuretic peptide (ANP) elicits natriuresis; however, the relative contributions of proximal and distal nephron segments to the overall ANP-induced natriuresis have remained uncertain. This study was performed to characterize the effects of ANP on distal nephron sodium reabsorption determined after blockade of the two major distal nephron sodium transporters with amiloride (5 μg/g body wt) plus bendroflumethiazide (12 μg/g body wt) in male anesthetized C57/BL6 and natriuretic peptide receptor-A gene (Npr1) targeted four-copy mice. The lower dose of ANP (0.1 ng·g body wt−1·min−1, n = 6) increased distal sodium delivery (DSD, 2.4 ± 0.4 vs. 1.6 ± 0.2 μeq/min, P < 0.05) but did not change fractional reabsorption of DSD compared with control (86.3 ± 2.0 vs. 83.9 ± 3.6%, P > 0.05), thus limiting the magnitude of the natriuresis. In contrast, the higher dose (0.2 ng·g body wt−1·min−1, n = 6) increased DSD (2.8 ± 0.3 μeq/min, P < 0.01) and also decreased fractional reabsorption of DSD (67.4 ± 4.5%, P < 0.01), which markedly augmented the natriuresis. In Npr1 gene-duplicated four-copy mice ( n = 6), the lower dose of ANP increased urinary sodium excretion (0.6 ± 0.1 vs. 0.3 ± 0.1 μeq/min, P < 0.05) and decreased fractional reabsorption of DSD compared with control (72.2 ± 3.4%, P < 0.05) at similar mean arterial pressures (91 ± 6 vs. 92 ± 3 mmHg, P > 0.05). These results provide in vivo evidence that ANP-mediated increases in DSD alone exert modest effects on sodium excretion and that inhibition of fractional reabsorption of distal sodium delivery is requisite for the augmented natriuresis in response to the higher dose of ANP or in Npr1 gene-duplicated mice.


Plant Science ◽  
2016 ◽  
Vol 250 ◽  
pp. 105-114 ◽  
Author(s):  
Kutubuddin Ali Molla ◽  
Subhasis Karmakar ◽  
Palas Kumar Chanda ◽  
Sailendra Nath Sarkar ◽  
Swapan Kumar Datta ◽  
...  

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Prerna Kumar ◽  
Meaghan Bloodworth ◽  
Venkateswara R. Gogulamudi ◽  
Kailash N. Pandey

2004 ◽  
Vol 13 (6) ◽  
pp. 567-581 ◽  
Author(s):  
Wan-Chi Lin ◽  
Ching-Fang Lu ◽  
Jia-Wei Wu ◽  
Ming-Lung Cheng ◽  
Yu-Mei Lin ◽  
...  

2008 ◽  
Vol 27 (3) ◽  
pp. 243-249 ◽  
Author(s):  
Jie-Tang Zhao ◽  
Xia Huang ◽  
Ya-Ping Chen ◽  
Yun-Feng Chen ◽  
Xue-Lin Huang
Keyword(s):  
Musa Spp ◽  

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