Prothymosin Alpha

2020 ◽  
Author(s):  
Keyword(s):  
Prothymosin Alpha

Prothymosin Alpha: An Alarmin and More...

2017 ◽  
Vol 24 (17) ◽  
Author(s):  
Pinelopi Samara ◽  
Chrysoula-Evangelia Karachaliou ◽  
Kyriaki Ioannou ◽  
Nikos E. Papaioannou ◽  
Ioannis F. Voutsas ◽  
...  
Keyword(s):  
Prothymosin Alpha

In Vitro Immunodetection of Prothymosin Alpha in Normal and Pathological Conditions

2020 ◽  
Vol 27 (29) ◽  
pp. 4840-4854 ◽  
Author(s):  
Chrysoula-Evangelia Karachaliou ◽  
Hubert Kalbacher ◽  
Wolfgang Voelter ◽  
Ourania E. Tsitsilonis ◽  
Evangelia Livaniou
Keyword(s):  
Mammalian Cells ◽  
Therapeutic Potential ◽  
Prothymosin Alpha ◽  
Disease States ◽  
Leading Role ◽  
Tissue Extracts ◽  
Biologic Response ◽  
Health And Disease ◽  
Almost All

Prothymosin alpha (ProTα) is a highly acidic polypeptide, ubiquitously expressed in almost all mammalian cells and tissues and consisting of 109 amino acids in humans. ProTα is known to act both, intracellularly, as an anti-apoptotic and proliferation mediator, and extracellularly, as a biologic response modifier mediating immune responses similar to molecules termed as “alarmins”. Antibodies and immunochemical techniques for ProTα have played a leading role in the investigation of the biological role of ProTα, several aspects of which still remain unknown and contributed to unraveling the diagnostic and therapeutic potential of the polypeptide. This review deals with the so far reported antibodies along with the related immunodetection methodology for ProTα (immunoassays as well as immunohistochemical, immunocytological, immunoblotting, and immunoprecipitation techniques) and its application to biological samples of interest (tissue extracts and sections, cells, cell lysates and cell culture supernatants, body fluids), in health and disease states. In this context, literature information is critically discussed, and some concluding remarks are presented.

scholarly journals Prothymosin alpha mRNA levels are invariant throughout the cell cycle.

1992 ◽  
Vol 267 (12) ◽  
pp. 8692-8695
Author(s):  
J.B. Zalvide ◽  
E Cancio ◽  
C.V. Alvarez ◽  
B.J. Regueiro ◽  
F Dominguez
Keyword(s):  
Cell Cycle ◽  
Mrna Levels ◽  
Prothymosin Alpha

scholarly journals Quality standard of recombinant prothymosin alpha and function in aquatic feed

2020 ◽  
Vol 18 ◽  
pp. 100426
Author(s):  
Kefu Zhou ◽  
Hao ran Li ◽  
Shiyuan Wang ◽  
Hua Li ◽  
Kun Meng ◽  
...  
Keyword(s):  
Quality Standard ◽  
Prothymosin Alpha ◽  
And Function

Expression of prothymosin-alpha and c-myc mRNA in human gastric cancer

1996 ◽  
Author(s):  
K Shibuta ◽  
M Mori ◽  
K Mimori ◽  
H Inoue ◽  
H Nakashima ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Human Gastric Cancer ◽  
Prothymosin Alpha

scholarly journals Tumour prothymosin alpha content, a potential prognostic marker for primary breast cancer

2000 ◽  
Vol 82 (3) ◽  
pp. 584-590 ◽  
Author(s):  
C Magdalena ◽  
F Dominguez ◽  
L Loidi ◽  
J L Puente
Keyword(s):  
Breast Cancer ◽  
Prognostic Marker ◽  
Primary Breast Cancer ◽  
Prothymosin Alpha
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