scholarly journals Borage Oil

2020 ◽  
Author(s):  
Keyword(s):  
Borage Oil

scholarly journals Prospective clinical trial examining the impact of genetic variation in FADS1 on the metabolism of linoleic acid– and ɣ-linolenic acid–containing botanical oils

2020 ◽  
Vol 111 (5) ◽  
pp. 1068-1078 ◽  
Author(s):  
Susan Sergeant ◽  
Brian Hallmark ◽  
Rasika A Mathias ◽  
Tammy L Mustin ◽  
Priscilla Ivester ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Linolenic Acid ◽  
Elevated Serum ◽  
Fatty Acid Desaturase ◽  
Borage Oil ◽  
Dependent Manner ◽  
Double Blind ◽  
Borago Officinalis ◽  
Markers Of Inflammation ◽  
The Impact

ABSTRACT Background Unexplained heterogeneity in clinical trials has resulted in questions regarding the effectiveness of ɣ-linolenic acid (GLA)-containing botanical oil supplements. This heterogeneity may be explained by genetic variation within the fatty acid desaturase (FADS) gene cluster that is associated with circulating and tissue concentrations of arachidonic acid (ARA) and dihomo-ɣ-linolenic acid (DGLA), both of which may be synthesized from GLA and result in proinflammatory and anti-inflammatory metabolites, respectively. Objectives The objective of this study was to prospectively compare the capacity of a non-Hispanic white cohort, stratified by FADS genotype at the key single-nucleotide polymorphism (SNP) rs174537, to metabolize 18-carbon omega-6 (n-6) PUFAs in borage oil (BO) and soybean oil (SO) to GLA, DGLA, and ARA. Methods Healthy adults (n = 64) participated in a randomized, double-blind, crossover intervention. Individuals received encapsulated BO (Borago officinalis L.; 37% LA and 23% GLA) or SO [Glycine max (L.) Merr.; 50% LA and 0% GLA] for 4 wk, followed by an 8-wk washout period, before consuming the opposite oil for 4 wk. Serum lipids and markers of inflammation (C-reactive protein) were assessed for both oil types at baseline and during weeks 2 and 4 of the intervention. Results SO supplementation failed to alter circulating concentrations of any n-6 long-chain PUFAs. In contrast, a modest daily dose of BO elevated serum concentrations of GLA and DGLA in an rs174537 genotype–dependent manner. In particular, DGLA increased by 57% (95% CI: 0.38, 0.79) in GG genotype individuals, but by 141% (95% CI: 1.03, 2.85) in TT individuals. For ARA, baseline concentrations varied substantially by genotype and increased modestly with BO supplementation, suggesting a key role for FADS variation in the balance of DGLA and ARA. Conclusions The results of this study clearly suggest that personalized and population-based approaches considering FADS genetic variation may be necessary to optimize the design of future clinical studies with GLA-containing oils. This trial was registered at clinicaltrials.gov as NCT02337231.

scholarly journals Essential fatty acids in breast milk of atopic mothers: comparison with non-atopic mothers, and effect of borage oil supplementation

2000 ◽  
Vol 54 (3) ◽  
pp. 234-238 ◽  
Author(s):  
C Thijs ◽  
A van Houwelingen ◽  
I Poorterman ◽  
A Mordant ◽  
P van den Brandt
Keyword(s):  
Fatty Acids ◽  
Breast Milk ◽  
Essential Fatty Acids ◽  
Borage Oil

In-vitro transcutaneous delivery of tamoxifen and γ-linolenic acid from borage oil containing ethanol and 1,8-cineole

2004 ◽  
Vol 56 (11) ◽  
pp. 1357-1364 ◽  
Author(s):  
Suzanna Ho ◽  
Richard J. Calder ◽  
Christopher P. Thomas ◽  
Charles M. Heard
Keyword(s):  
Linolenic Acid ◽  
Borage Oil ◽  
Transcutaneous Delivery

Borage Oil

2016 ◽  
Author(s):  
J. Beare-Rogers ◽  
A. Dieffenbacher ◽  
J. V. Holm
Keyword(s):  
Borage Oil

scholarly journals Rationale and use of n-3 fatty acids in artificial nutrition

2010 ◽  
Vol 69 (4) ◽  
pp. 565-573 ◽  
Author(s):  
Philip C. Calder
Keyword(s):  
Fatty Acids ◽  
Fish Oil ◽  
Immune Function ◽  
Partial Replacement ◽  
Borage Oil ◽  
Artificial Nutrition ◽  
Clinical Endpoints ◽  
Post Surgery ◽  
Organ Failures ◽  
Critically Ill Adults

Lipids traditionally used in artificial nutrition are based on n-6 fatty acid-rich vegetable oils like soyabean oil. This may not be optimal because it may present an excessive supply of linoleic acid. One alternative to the use of soyabean oil is its partial replacement by fish oil, which contains n-3 fatty acids. These fatty acids influence inflammatory and immune responses and so may be useful in particular situations where those responses are not optimal. Fish oil-containing lipid emulsions have been used in parenteral nutrition in adult patients post-surgery (mainly gastrointestinal). This has been associated with alterations in patterns of inflammatory mediators and in immune function and, in some studies, a reduction in length of intensive care unit (ICU) and hospital stay. Perioperative administration of fish oil may be superior to post-operative. Parenteral fish oil has been used in critically ill adults. Here the influence on inflammatory processes, immune function and clinical endpoints is not clear, since there are too few studies and those that are available report contradictory findings. Fish oil is included in combination with other nutrients in various enteral formulas. In post-surgical patients and in those with mild sepsis or trauma, there is clinical benefit from a formula including fish oil and arginine. A formula including fish oil, borage oil and antioxidants has demonstrated marked benefits on gas exchange, ventilation requirement, new organ failures, ICU stay and mortality in patients with acute respiratory distress syndrome, acute lung injury or severe sepsis.

Association of Borage Oil and Betamethasone Dipropionate in Lipid-Core Nanocapsules: Characterization, Photostability and In Vitro Irritation Test

2016 ◽  
Vol 16 (2) ◽  
pp. 1354-1362 ◽  
Author(s):  
Julia Weber ◽  
Nadine L. Funk ◽  
Mariana H. Motta ◽  
Alessandra M. Guedes ◽  
Ana Paula C. Visintainer ◽  
...  
Keyword(s):  
Betamethasone Dipropionate ◽  
Borage Oil ◽  
Lipid Core ◽  
Irritation Test
Sign in / Sign up

Export Citation Format

Share Document