Doxazosin Mesylate

2020 ◽  
Author(s):  
Keyword(s):  
Doxazosin Mesylate

scholarly journals Spectrophotometric Determination of Doxazosin Mesylate in Tablets by Ion-Pair and Charge-Transfer Complexation Reactions

2009 ◽  
Vol 92 (1) ◽  
pp. 131-137 ◽  
Author(s):  
Zeynep Aydomu ◽  
Asli Barla
Keyword(s):  
Charge Transfer ◽  
Ion Pair ◽  
Bromophenol Blue ◽  
Bromocresol Purple ◽  
Charge Transfer Reaction ◽  
Accuracy And Precision ◽  
Doxazosin Mesylate ◽  
Significant Difference ◽  
Complexation Reactions

Abstract Two accurate, easy spectrophotometric methods for the determination of doxazosin mesylate were described. The first method was based on the formation of ion-pair complexes with the acidic sulfophthalein dyes bromocresol purple (BCP) and bromophenol blue (BPB) in pH 3.3 and 4.5 citratephosphate buffer, respectively. The formed complexes were extracted into dichloromethane, and their absorbance was measured at 403 and 410 nm for BCP and BPB, respectively. The second method was based on the charge transfer reaction of the drug as an n-electron donor with either 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) or 7,7,8,8-tetracyanoquinodimethane (TCNQ) as -acceptors, to give colored radical anions. The absorbances of products were measured at 457 nm in acetonitrile and 838 nm in methanol for DDQ and TCNQ, respectively. Under the optimum reaction conditions, Beer's law was obeyed with a good correlation coefficient (r = 0.99970.9999) in the concentration ranges 3.018.0, 3.020.0, 15.095.0, and 10.0100.0 g/mL for the BCP, BPB, DDQ, and TCNQ methods, respectively. Limits of detection of the BCP, BPB, DDQ, and TCNQ methods were 0.314, 0.408, 1.935, and 1.610 g/mL, respectively. The limits of quantification were 1.045, 1.360, 6.449, and 5.367 g/mL, respectively. The parameters molar absorptivity, precision, accuracy, recovery, robustness, and stability constant were studied. The proposed methods were successfully applied for determination of the drug in tablets with good accuracy and precision. Statistical comparison of the results with those obtained by a reported method showed good agreement and indicated no significant difference in accuracy and precision.

Formulation development and evaluation of orally disintegrating tablets of doxazosin mesylate

2012 ◽  
Vol 6 (4) ◽  
pp. 266
Author(s):  
ShilpaP Chaudhari ◽  
NeerajR Kotian ◽  
MaheshM Bhadgale ◽  
VardhmanC Bafna
Keyword(s):  
Formulation Development ◽  
Orally Disintegrating Tablets ◽  
Doxazosin Mesylate

Homologous recombination induced by doxazosin mesylate and saw palmetto in theDrosophilawing-spot test

2011 ◽  
Vol 33 (3) ◽  
pp. 209-213 ◽  
Author(s):  
Katiane Cella Gabriel ◽  
Rafael Rodrigues Dihl ◽  
Mauricio Lehmann ◽  
Maria Luiza Reguly ◽  
Marc François Richter ◽  
...  
Keyword(s):  
Homologous Recombination ◽  
Spot Test ◽  
Saw Palmetto ◽  
Doxazosin Mesylate

Protonation site and hydrogen bonding in anhydrous and hydrated crystalline forms of doxazosin mesylate from powder data

2003 ◽  
Vol 59 (6) ◽  
pp. 787-793 ◽  
Author(s):  
Vladimir V. Chernyshev ◽  
Denis Machon ◽  
Andrew N. Fitch ◽  
Sergei A. Zaitsev ◽  
Alexandr V. Yatsenko ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Three Dimensional ◽  
Water Molecules ◽  
Protonation Site ◽  
X Ray ◽  
Space Groups ◽  
Solvent Water ◽  
Doxazosin Mesylate ◽  
Crystalline Forms ◽  
Solid State Structures

The three-dimensional solid-state structures of two modifications of doxazosin mesylate C23H26N5O_5^+·CH3SO_3^-, 4-amino-2-[4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazin-1-yl]-6,7-dimethoxyquinazoline methanesulfonate, a commonly used antihypertensive agent, have been determined by synchrotron X-ray powder diffraction. An anhydrous form (A) and a dihydrate form (d G) crystallize in monoclinic space groups. In both forms the doxazosin molecule is protonated at the N1 atom of the quinazoline bicycle. The N1 atom, and the amino H atoms and O atoms of the mesylate moieties are involved in three-dimensional hydrogen-bonding networks, while solvent water molecules and carboxamide O atoms are also incorporated in a hydrogen-bonding network in d G.

Polymorphism of doxazosin mesylate

2005 ◽  
Vol 28 (6) ◽  
pp. 730-735 ◽  
Author(s):  
Young-Taek Sohn ◽  
Yoon-Hee Lee
Keyword(s):  
Doxazosin Mesylate
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