Internal Granular Layer of the Cerebral Cortex

2020 ◽  
Author(s):  
Keyword(s):  
Cerebral Cortex ◽  
Granular Layer ◽  
Internal Granular Layer

The Subpial Granular Layer in the Developing Cerebral Cortex of Rodents

2000 ◽  
pp. 277-291 ◽  
Author(s):  
Gundela Meyer ◽  
Rafael Castro ◽  
José Miguel Soria ◽  
Alfonso Fairén
Keyword(s):  
Cerebral Cortex ◽  
Granular Layer

NEUROGLIA IN THE INTERNAL GRANULAR LAYER OF THE DEVELOPING RAT CEREBELLAR CORTEX

1977 ◽  
Vol 3 (3) ◽  
pp. 183-190 ◽  
Author(s):  
P. D. LEWIS ◽  
Z. FüLÖP ◽  
F. HAJÓS ◽  
R. BALÁZS ◽  
P. L. WOODHAMS
Keyword(s):  
Cerebellar Cortex ◽  
Granular Layer ◽  
Internal Granular Layer ◽  
Developing Rat

scholarly journals A rare WHO Grade I Lesion of the Posterior Fossa with Recurrence Biological Behavior - Dysplastic Gangliocytoma of the Cerebellum: Case Report

2020 ◽  
Vol 39 (02) ◽  
pp. 132-135
Author(s):  
Leandro Pelegrini de Almeida ◽  
Felipe Lourezon Schiavo ◽  
Samir Cezimbra dos Santos ◽  
William Mazzucco Nesi ◽  
Eduardo Cambruzzi
Keyword(s):  
Granular Layer ◽  
Ganglion Cells ◽  
Obstructive Hydrocephalus ◽  
Molecular Layer ◽  
Suppressor Gene ◽  
World Health ◽  
Biological Behavior ◽  
Who Grade ◽  
Dysplastic Gangliocytoma ◽  
Internal Granular Layer

AbstractDysplastic gangliocytoma of the cerebellum (DGC) or Lhermitte-Duclos Disease is a rare lesion (World Health Organization [WHO] grade I) characterized by thickened folia and replacement of the internal granular layer by abnormal ganglion cells. More commonly, the compromised patients are young adults presenting ataxia, seizures, obstructive hydrocephalus, and increased intracranial pressure. Dysplastic gangliocytoma of the cerebellum is intimately associated with Cowden syndrome, a hereditary disorder caused by a germline mutation in the PTEN tumor suppressor gene on chromosome 10q23. Large neurons of DCG show vesicular nuclei with prominent nucleoli. Expansion of the internal granular layer determines vacuolization of the molecular layer and white matter, which can be related to the bright stripes identified on T2-weighted magnetic resonance imaging. Herein, the authors report a female patient who developed long- time recurrence of DGC and discuss pathological findings and differential diagnosis of this rare cerebellar lesion.

scholarly journals Analysis of Histological Features of the Cerebral Cortex and Hippocampus of Albino Rats Using Haematoxylin & Eosin Stain- An Observational Study

2021 ◽  
pp. 53-64
Author(s):  
M. V. Shreejha ◽  
R. Priyadharshini ◽  
Palati Sinduja ◽  
V. Meghashree
Keyword(s):  
Cerebral Cortex ◽  
Observational Study ◽  
Rat Brain ◽  
Granular Layer ◽  
Molecular Layer ◽  
Pyramidal Cells ◽  
Stratum Radiatum ◽  
Albino Rats ◽  
Histological Features ◽  
Pyramidal Layer

Background: The study determined the histological layers of the cerebral cortex and hippocampus of the albino rat brain samples has been used in the study. The Cerebral cortex is composed of the Molecular layer, external granular, external pyramidal layer, internal granular layer and interior pyramidal layer. The layers of the hippocampus are alveus, stratum oriens, stratum pyramidale, stratum radiatum, stratum lacunosum and stratum moleculare. The aim of the study is to analyze the detailed histological features of the cerebral cortex and hippocampus layers of albino rats at the magnification of 10X,100X,40X. By using haematoxylin and eosin stain as an observational study. Materials and Methods: The samples were preserved and fixed with the formalin and stained by haematoxylin and eosin and observed with a light microscope. Results: The molecular layer is the superficial layer containing neurons. The outer granular layer of the cells are densely packed. Outer pyramidal layer contains rich pyramidal cells, Inner granular layer contains stellate cells, Inner pyramidal layer contains glial cells and the deeper multiform layer is composed of pyramidal cells. The hippocampus contains three layers of cornu Ammonia CA1, CA2, CA3. CA1 responds to memory and is covered by the choroid plexus. CA2 contains 3 major cell dentate gyrus, pyramidal cells, pyramidal neurons and CA3 composed of stratum lucidum. Conclusion: The study of brain analysis of histological features of the cerebral cortex and hippocampus of the brain adds a greater insight in understanding the histology of various types of layers in rat brain and morphology of brain cells.

The discovery of the subpial granular layer in the human cerebral cortex

2010 ◽  
Vol 1 (3) ◽  
Author(s):  
Miloš Judaš ◽  
Mihovil Pletikos
Keyword(s):  
Cerebral Cortex ◽  
Granular Layer ◽  
Original Description ◽  
Additional Source ◽  
Human Cerebral Cortex ◽  
Precursor Pool ◽  
Concise Review ◽  
Cortical Interneurons ◽  
Retzius Cells ◽  
Putative Precursor

AbstractThe subpial granular layer (SGL) is a transient accumulation of tangentially migrating small granular neurons in the marginal zone of the developing fetal neocortex. It has recently attracted attention as a possible additional source of future cortical interneurons, or even as a putative precursor pool for generation of Cajal-Retzius cells. The discovery of the SGL is generally attributed to Otto Ranke and it is usually claimed that the SGL is specific for human brain. The aim of this review is: (1) to demonstrate that the first to observe SGL in the human cerebral cortex was not Otto Ranke in 1910, but Franz Boll in 1874; (2) to provide an English translation of Ranke’s original description of the SGL and thus demonstrate that he described the SGL in both human and animal brain; and (3) to provide a concise review of current studies concerning the developmental fate and possible functions of the transient fetal SGL.

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