scholarly journals TIMP1 Gene

2020 ◽  
Author(s):  
Keyword(s):  
Timp1 Gene

scholarly journals Potent inhibition of arterial intimal hyperplasia by TIMP1 gene transfer using AAV vectors

2004 ◽  
Vol 9 (6) ◽  
pp. 876-884 ◽  
Author(s):  
Genaro A Ramirez Correa ◽  
Serena Zacchigna ◽  
Nikola Arsic ◽  
Lorena Zentilin ◽  
Alessandro Salvi ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Intimal Hyperplasia ◽  
Potent Inhibition ◽  
Timp1 Gene

scholarly journals Angiogenic capacity of M1- and M2-polarized macrophages is determined by the levels of TIMP-1 complexed with their secreted proMMP-9

Blood ◽  
2013 ◽  
Vol 122 (25) ◽  
pp. 4054-4067 ◽  
Author(s):  
Ewa Zajac ◽  
Bernhard Schweighofer ◽  
Tatyana A. Kupriyanova ◽  
Anna Juncker-Jensen ◽  
Petra Minder ◽  
...  
Keyword(s):  
Gene Expression ◽  
Murine Macrophages ◽  
Key Points ◽  
Timp1 Gene ◽  
M2 Phenotype

Key Points Acquisition of high angiogenesis-inducing capacity by human and murine macrophages requires their polarization toward the M2 phenotype. M2-polarized macrophages shutdown their TIMP1 gene expression and initiate production of highly angiogenic TIMP-deficient proMMP-9.

scholarly journals Polymorphic X-Chromosome Inactivation of the Human TIMP1 Gene

1999 ◽  
Vol 65 (3) ◽  
pp. 699-708 ◽  
Author(s):  
Catherine L. Anderson ◽  
Carolyn J. Brown
Keyword(s):  
X Chromosome ◽  
X Chromosome Inactivation ◽  
Chromosome Inactivation ◽  
Timp1 Gene

scholarly journals Collagen/Chitosan Gels Cross-Linked with Genipin for Wound Healing in Mice with Induced Diabetes

Materials ◽  
2021 ◽  
Vol 15 (1) ◽  
pp. 15
Author(s):  
Balzhima Shagdarova ◽  
Mariya Konovalova ◽  
Yuliya Zhuikova ◽  
Alexey Lunkov ◽  
Vsevolod Zhuikov ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Closure ◽  
Collagen Deposition ◽  
Sebaceous Glands ◽  
Hemostatic Effect ◽  
Potential Applications ◽  
Low Toxicity ◽  
Cd1 Mice ◽  
Diabetic Wounds ◽  
Timp1 Gene

Diabetes mellitus continues to be one of the most common diseases often associated with diabetic ulcers. Chitosan is an attractive biopolymer for wound healing due to its biodegradability, biocompatibility, mucoadhesiveness, low toxicity, and hemostatic effect. A panel of hydrogels based on chitosan, collagen, and silver nanoparticels were produced to treat diabetic wounds. The antibacterial activity, cytotoxicity, swelling, rheological properties, and longitudinal sections of hydrogels were studied. The ability of the gels for wound healing was studied in CD1 mice with alloxan-induced diabetes. Application of the gels resulted in an increase in VEGF, TGF-b1, IL-1b, and TIMP1 gene expression and earlier wound closure in a comparison with control untreated wounds. All gels increased collagen deposition, hair follicle repair, and sebaceous glands formation. The results of these tests show that the obtained hydrogels have good mechanical properties and biological activity and have potential applications in the field of wound healing. However, clinical studies are required to compare the efficacy of the gels as animal models do not reproduce full diabetes pathology.

Survivin-TGFB3-TIMP1 Gene Therapy Via Lentivirus Vector Slows the Course of Intervertebral Disc Degeneration in an In Vivo Rabbit Model

Spine ◽  
2016 ◽  
Vol 41 (11) ◽  
pp. 926-934 ◽  
Author(s):  
Bin Yue ◽  
YaZhou Lin ◽  
XueXiao Ma ◽  
HongFei Xiang ◽  
ChenSheng Qiu ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
Rabbit Model ◽  
Lentivirus Vector ◽  
Timp1 Gene

scholarly journals Modulation of the Extracellular Signal-Regulated Protein Kinase and Tissue Inhibitors of Matrix Metalloproteases-1 Gene in Chronic Neuropathic Pain

2021 ◽  
Vol 27 ◽  
pp. 251-256
Author(s):  
Ashok Kumar Saxena ◽  
Deepanshu Khrolia ◽  
Geetanjali T Chilkoti ◽  
Prakash Gyandev Gondode ◽  
Tusha Sharma ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Neuropathic Pain ◽  
Protein Kinase ◽  
Mrna Expression ◽  
Quantitative Polymerase Chain Reaction ◽  
Matrix Metalloproteases ◽  
Pain Clinic ◽  
Tissue Inhibitors ◽  
Extracellular Signal ◽  
Timp1 Gene

Objectives: The aim of this study is to study the modulation of extracellular signal-regulated protein kinase (ERK) and tissue inhibitors of matrix metalloproteases 1 (TIMP 1) gene in patients with neuropathic pain (NP). Materials and Methods: In the present, cross-sectional, observational study, 2 ml of venous baseline sample was withdrawn from all the patients with neuropathic (NP) or non NP (NNP) soon after their diagnosis or on their first visit to the pain clinic. A real-time quantitative polymerase chain reaction experiment was conducted to measure the mRNA expression of TIMP1 and ERK genes in blood samples. The Delta Ct, Delta Ct, and fold change analysis of both the genes were conducted between patients with NP and NNP. Results: A total of 285 patients with chronic pain were assessed, out of which, 153 patients had NP and 132 had NNP. The average duration of chronic pain was 11 months for 285 patients. The mRNA expression of TIMP1 gene is significantly down regulated (2.65-fold) (P (-f. 01), and the mRNA expression level of ERK is significantly up regulated (2.03-fold) (P (-f. 01) in NP patients when compared with NNP. Conclusion: The mRNA expression of TIMP1 gene is significantly down regulated, and ERK is significantly up regulated in patients with NP. Further, multicentric trials with larger sample size are recommended to confirm this finding.

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