Goodpasture Syndrome

2020 ◽  
Author(s):  
Keyword(s):  
Goodpasture Syndrome

Osteopontin expressed by renal tubular epithelium mediates interstitial monocyte infiltration in rats

2000 ◽  
Vol 278 (1) ◽  
pp. F110-F121 ◽  
Author(s):  
Hirokazu Okada ◽  
Kenshi Moriwaki ◽  
Raghuram Kalluri ◽  
Tsuneo Takenaka ◽  
Hiroe Imai ◽  
...  
Keyword(s):  
Target Genes ◽  
Renal Plasma Flow ◽  
Mrna Level ◽  
Antisense Oligodeoxynucleotide ◽  
Tubular Epithelium ◽  
Rt Pcr ◽  
Goodpasture Syndrome ◽  
Renal Tubular Epithelium ◽  
Protein Excretion ◽  
Renal Tubular

In this study, we have shown that intravenously administered antisense oligodeoxynucleotide (ODN) was demonstrated to be taken up by tubular epithelium, after which it blocked mRNA expression of target genes in normal and nephritic rats. Therefore, we injected osteopontin (OPN) antisense ODN to Goodpasture syndrome (GPS) rats every second day between days 27 and 35, the time when renal OPN expression increased and interstitial monocyte infiltration was aggravated. In parallel to blockade of tubular OPN expression, this treatment significantly attenuated monocyte infiltration and preserved renal plasma flow in GPS rats at day 37, compared with sense ODN-treated and untreated GPS rats. No significant changes were observed in OPN mRNA level by RT-PCR and histopathology of the glomeruli after ODN treatment, which was compatible with an absence of differences in the urinary protein excretion rate. In conclusion, OPN expressed by tubular epithelium played a pivotal role in mediating peritubular monocyte infiltration consequent to glomerular disease.

scholarly journals Anti-GBM antibodies in Goodpasture syndrome; anatomy of an epitope

1997 ◽  
Vol 12 (4) ◽  
pp. 646-648 ◽  
Author(s):  
T. Hellmark ◽  
M. Segelmark ◽  
J. Wieslander
Keyword(s):  
Goodpasture Syndrome

Pulmonary Vasculitis

Chest Imaging ◽  
2019 ◽  
pp. 355-359
Author(s):  
Felipe Martínez
Keyword(s):  
Granulomatosis With Polyangiitis ◽  
Vascular Wall ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Small Vessel Vasculitis ◽  
Eosinophilic Granulomatosis With Polyangiitis ◽  
Goodpasture Syndrome ◽  
Work Up ◽  
Eosinophilic Granulomatosis ◽  
Common Manifestation

Vasculitis refers to inflammation of blood vessel walls that results in vascular wall destruction and ischemic injury to affected organs. Common vasculitides discussed herein include Takayasu arteritis (TAK), giant cell arteritis (GCA), antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides such as granulomatosis with polyangiitis (GPA) and eosinophilic granulomatosis with polyangiitis (EGPA), and anti-glomerular basement membrane (anti-GBM) disease or Goodpasture syndrome. Vasculitides are further subcategorized depending of the size of the predominantly affected vessels: large, medium and small vessel vasculitis. The affected vessel size strongly influences the clinical and imaging manifestations of the disease. Intrathoracic involvement is more common in small and large vessel vasculitides. Diffuse alveolar hemorrhage (DAH), a common manifestation of vasculitis, is considered a syndrome rather than a specific entity and will be discussed in this chapter. However, it should be noted that DAH may also result from non-vasculitic etiologies. The work up and diagnosis of patients with primary vasculitides is challenging and requires close collaboration between the clinician, the radiologist and the pathologist. Radiographic abnormalities are non specific or may be absent. CT and MRI are the imaging modalities of choice for the evaluation and follow up of these patients, and should be considered despite normal radiographics.

scholarly journals The alpha 3 chain of type IV collagen induces autoimmune Goodpasture syndrome.

1994 ◽  
Vol 91 (13) ◽  
pp. 6201-6205 ◽  
Author(s):  
R. Kalluri ◽  
V. H. Gattone ◽  
M. E. Noelken ◽  
B. G. Hudson
Keyword(s):  
Type Iv Collagen ◽  
Goodpasture Syndrome ◽  
Type Iv

Goodpasture syndrome with recovery after renal failure

JAMA ◽  
1974 ◽  
Vol 229 (4) ◽  
pp. 444-444
Author(s):  
B. S. Strauch
Keyword(s):  
Renal Failure ◽  
Goodpasture Syndrome

scholarly journals Idiopathic pulmonary haemosiderosis and the Goodpasture syndrome.

BMJ ◽  
1965 ◽  
Vol 2 (5471) ◽  
pp. 1152-1155 ◽  
Author(s):  
J. L. Elder ◽  
G. M. Kirk ◽  
W. G. Smith
Keyword(s):  
Goodpasture Syndrome ◽  
Idiopathic Pulmonary Haemosiderosis
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