scholarly journals Lymphatic Capillary

2020 ◽  
Author(s):  
Keyword(s):  
Lymphatic Capillary

Ultrastructure of Lymphatic Capillaries in the Transport of Colloidal Particles

1967 ◽  
Vol 25 ◽  
pp. 186-187
Author(s):  
L. V. Leak ◽  
J. F. Burke
Keyword(s):  
Connective Tissue ◽  
Colloidal Particles ◽  
Ultrastructural Level ◽  
Vital Role ◽  
Time Intervals ◽  
Thorium Dioxide ◽  
Lymphatic Capillary ◽  
Tissue Area ◽  
Rapid Removal ◽  
Tissue Fluids

The vital role played by the lymphatic capillaries in the transfer of tissue fluids and particulate materials from the connective tissue area can be demonstrated by the rapid removal of injected vital dyes into the tissue areas. In order to ascertain the mechanisms involved in the transfer of substances from the connective tissue area at the ultrastructural level, we have injected colloidal particles of varying sizes which range from 80 A up to 900-mμ. These colloidal particles (colloidal ferritin 80-100A, thorium dioxide 100-200 A, biological carbon 200-300 and latex spheres 900-mμ) are injected directly into the interstitial spaces of the connective tissue with glass micro-needles mounted in a modified Chambers micromanipulator. The progress of the particles from the interstitial space into the lymphatic capillary lumen is followed by observing tissues from animals (skin of the guinea pig ear) that were injected at various time intervals ranging from 5 minutes up to 6 months.

Development of Lymphatic Capillary Network Along the Alveolar Walls of Autopsied Human Lungs with Pneumonia

2016 ◽  
Vol 14 (4) ◽  
pp. 210-219
Author(s):  
Masahiro Yamashita ◽  
Miyuki Niisato ◽  
Tomohito Hanasaka ◽  
Noriyuki Iwama ◽  
Tohru Takahashi ◽  
...  
Keyword(s):  
Capillary Network ◽  
Lymphatic Capillary ◽  
Human Lungs

scholarly journals Arteriovenous Malformation of the Oral Cavity

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
S. M. Manjunath ◽  
Sujan Shetty ◽  
Ninad J. Moon ◽  
Bhushan Sharma ◽  
Kiran Kumar Metta ◽  
...  
Keyword(s):  
Arteriovenous Malformation ◽  
Arteriovenous Malformations ◽  
Vascular Malformations ◽  
Vascular Anomaly ◽  
Benign Disease ◽  
Vascular Tumors ◽  
Management Approach ◽  
Lymphatic Capillary ◽  
Clinical Behavior ◽  
Specific Morphology

Vascular anomalies are a heterogeneous group of congenital blood vessel disorders more typically referred to as birthmarks. Subcategorized into vascular tumors and malformations, each anomaly is characterized by specific morphology, pathophysiology, clinical behavior, and management approach. Hemangiomas are the most common vascular tumors. Lymphatic, capillary, venous, and arteriovenous malformations make up the majority of vascular malformations. Arteriovenous malformation of the head and neck is a rare vascular anomaly but when present is persistent and progressive in nature and can represent a lethal benign disease. Here we present a case report of a 25-year-old male patient with arteriovenous malformation involving the base of tongue.

scholarly journals CRSBP-1/LYVE-l-null mice exhibit identifiable morphological and functional alterations of lymphatic capillary vessels

FEBS Letters ◽  
2006 ◽  
Vol 580 (26) ◽  
pp. 6259-6268 ◽  
Author(s):  
S.S. Huang ◽  
I-Hua Liu ◽  
Tracy Smith ◽  
Maulik R. Shah ◽  
Frank E. Johnson ◽  
...  
Keyword(s):  
Lymphatic Capillary

Eustachian Tube Lymphatics

1975 ◽  
Vol 84 (4) ◽  
pp. 483-492 ◽  
Author(s):  
Jack L. Pulec ◽  
Tomokazu Kamio ◽  
Malcolm D. Graham
Keyword(s):  
Electron Microscopy ◽  
Basement Membrane ◽  
Otitis Media ◽  
Eustachian Tube ◽  
Blood Capillary ◽  
Lymphatic Capillary ◽  
Blood Capillaries ◽  
First Time ◽  
Serous Otitis Media

Serous otitis media is the most common cause of hearing impairment. The role of lymphatic obstruction in the pathogenesis of serous otitis media is significant. A method for removal of the human Eustachian tube specimen and two techniques for identification of Eustachian tube lymphatic capillaries are described. One involves the antemortem intratympanic installation of Berlin blue. The other utilizes electron microscopy. Lymphatic capillaries cannot be reliably differentiated from blood capillaries with the light microscope. With electron microscopy, lymphatic capillaries can be differentiated from blood capillaries by differences in the basement membrane. The lymphatic capillary has gaps in the basement membrane with large nuclei in the wall. A blood capillary has a continuous basement membrane and sometimes red blood cells can be identified in the lumen. Using these methods, Eustachian tube lymphatic capillaries in the human are described for the first time in this report.

scholarly journals ULTRASTRUCTURAL STUDIES ON THE LYMPHATIC ANCHORING FILAMENTS

1968 ◽  
Vol 36 (1) ◽  
pp. 129-149 ◽  
Author(s):  
L. V. Leak ◽  
J. F. Burke
Keyword(s):  
Connective Tissue ◽  
Extracellular Space ◽  
Collagen Fibers ◽  
Capillary Wall ◽  
Surrounding Tissue ◽  
Elastic Fibers ◽  
Lymphatic Capillary ◽  
Ultrastructural Studies ◽  
Outer Leaflet ◽  
Tissue Area

The fine structure of the lymphatic capillary and the surrounding tissue areas was investigated. Instead of a continuous basal lamina (basement membrane) surrounding the capillary wall, these observations revealed the occurrence of numerous fine filaments that insert on the outer leaflet of the trilaminar unit membrane of the lymphatic endothelium. These filaments appear as individual units, or they are aggregated into bundles that are disposed parallel to the long axis of the lymphatic capillary wall and extend for long distances into the adjoining connective tissue area among the collagen fibers and connective tissue cells. The filaments measure about 100 A in width and have a hollow profile. They exhibit an irregular beaded pattern along their long axis and are densely stained with uranyl and lead. These filaments are similar to the microfibrils of the extracellular space and the filaments observed in the peripheral mantle of the elastic fibers. Infrequently, connections between these various elements are observed, suggesting that the lymphatic anchoring filaments may also contribute to the filamentous units of the extracellular space. It is suggested that these lymphatic anchoring filaments connect the small lymphatics to the surrounding tissues and represent the binding mechansim that is responsible for maintaining the firm attachment of the lymphatic capillary wall to the adjoining collagen fibers and cells of the connective tissue area.

scholarly journals FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1

2009 ◽  
Vol 185 (3) ◽  
pp. 439-457 ◽  
Author(s):  
Camilla Norrmén ◽  
Konstantin I. Ivanov ◽  
Jianpin Cheng ◽  
Nadine Zangger ◽  
Mauro Delorenzi ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Lymphatic Vessels ◽  
Morphological Characterization ◽  
Forkhead Transcription Factor ◽  
Lymphatic Capillary ◽  
A Genome ◽  
Capillary Plexus ◽  
Identify Transcription Factor ◽  
Vessel Maturation ◽  
Lymphatic Development

The mechanisms of blood vessel maturation into distinct parts of the blood vasculature such as arteries, veins, and capillaries have been the subject of intense investigation over recent years. In contrast, our knowledge of lymphatic vessel maturation is still fragmentary. In this study, we provide a molecular and morphological characterization of the major steps in the maturation of the primary lymphatic capillary plexus into collecting lymphatic vessels during development and show that forkhead transcription factor Foxc2 controls this process. We further identify transcription factor NFATc1 as a novel regulator of lymphatic development and describe a previously unsuspected link between NFATc1 and Foxc2 in the regulation of lymphatic maturation. We also provide a genome-wide map of FOXC2-binding sites in lymphatic endothelial cells, identify a novel consensus FOXC2 sequence, and show that NFATc1 physically interacts with FOXC2-binding enhancers. As damage to collecting vessels is a major cause of lymphatic dysfunction in humans, our results suggest that FOXC2 and NFATc1 are potential targets for therapeutic intervention.

scholarly journals Infection-Induced Dermal Lymphatic Zippering Restricts Viral Dissemination from Skin and Promotes Anti-Viral CD8+ T Cell Expansion

2021 ◽  
Author(s):  
Madeline J. Churchill ◽  
Haley du Bois ◽  
Taylor A. Heim ◽  
Tenny Mudianto ◽  
Maria M. Steele ◽  
...  
Keyword(s):  
T Cell ◽  
Lymph Nodes ◽  
Vaccinia Virus ◽  
Host Defense ◽  
Lymphatic Vessels ◽  
T Cell Responses ◽  
Lymphatic Capillary ◽  
Viral Dissemination ◽  
Cell Responses ◽  
Draining Lymph Nodes

AbstractLymphatic vessels are often considered passive conduits that rapidly flush antigenic material, pathogens, and cells to draining lymph nodes. Recent evidence, however, suggests that lymphatic vessels actively regulate diverse processes from antigen transport to leukocyte trafficking and dietary lipid absorption. Here we tested the hypothesis that dermal lymphatic transport is dynamic and contributes to innate host defense during viral infection. We demonstrate that cutaneous vaccinia virus infection activates the tightening of lymphatic interendothelial junctions, termed zippering, in a VEGFA/VEGFR2-dependent manner. Both antibody-mediated blockade of VEGFA/VEGFR2 and lymphatic-specific deletion of Vegfr2 impaired lymphatic capillary zippering and increased fluid flux out of tissue. Strikingly, inhibition of lymphatic zippering allows viral dissemination to draining lymph nodes independent of dendritic cell migration and impairs CD8+ T cell priming. These data indicate that infection-induced dermal lymphatic capillary zippering is a context-dependent, active mechanism of innate host defense that limits interstitial fluid and virion flux and promotes protective, anti-viral CD8+ T cell responses.SummaryCutaneous infection with vaccinia virus induces VEGFR2-dependent dermal lymphatic capillary zippering. This tightening of lymphatic junctions exacerbates tissue edema, sequesters virus, and promotes anti-viral CD8+ T cell responses. Dermal lymphatic capillaries are therefore an active component of innate host defense.

scholarly journals The Role of Methionine Aminopeptidase 2 in Lymphangiogenesis

2020 ◽  
Vol 21 (14) ◽  
pp. 5148
Author(s):  
Rawnaq Esa ◽  
Eliana Steinberg ◽  
Dvir Dror ◽  
Ouri Schwob ◽  
Mehrdad Khajavi ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cell Function ◽  
Loss Of Function ◽  
Methionine Aminopeptidase ◽  
Zebrafish Model ◽  
Lymphatic Capillary ◽  
Intracellular Enzyme

During the metastasis process, tumor cells invade the blood circulatory system directly from venous capillaries or indirectly via lymphatic vessels. Understanding the relative contribution of each pathway and identifying the molecular targets that affect both processes is critical for reducing cancer spread. Methionine aminopeptidase 2 (MetAp2) is an intracellular enzyme known to modulate angiogenesis. In this study, we investigated the additional role of MetAp2 in lymphangiogenesis. A histological staining of tumors from human breast-cancer donors was performed in order to detect the level and the localization of MetAp2 and lymphatic capillaries. The basal enzymatic level and activity in vascular and lymphatic endothelial cells were compared, followed by loss of function studies determining the role of MetAp2 in lymphangiogenesis in vitro and in vivo. The results from the histological analyses of the tumor tissues revealed a high MetAp2 expression, with detectable sites of co-localization with lymphatic capillaries. We showed slightly reduced levels of the MetAp2 enzyme and MetAp2 mRNA expression and activity in primary lymphatic cells when compared to the vascular endothelial cells. The genetic and biochemical manipulation of MetAp2 confirmed the dual activity of the enzyme in both vascular and lymphatic remodulation in cell function assays and in a zebrafish model. We found that cancer-related lymphangiogenesis is inhibited in murine models following MetAp2 inhibition treatment. Taken together, our study provides an indication that MetAp2 is a significant contributor to lymphangiogenesis and carries a dual role in both vascular and lymphatic capillary formation. Our data suggests that MetAp2 inhibitors can be effectively used as anti-metastatic broad-spectrum drugs.

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