scholarly journals Squamous Cell Carcinoma, Clear Cell Type

2020 ◽  
Author(s):  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Clear Cell ◽  
Cell Type ◽  
Clear Cell Type

Non-Overlapping and Non–Cell-Type–Specific Gene Expression Signatures Predict Lung Cancer Survival

2008 ◽  
Vol 26 (6) ◽  
pp. 877-883 ◽  
Author(s):  
Zhifu Sun ◽  
Dennis A. Wigle ◽  
Ping Yang
Keyword(s):  
Gene Expression ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Gene Signature ◽  
Data Sets ◽  
Cell Type ◽  
Validation Data ◽  
Adjusted Risk ◽  
Gene Expression Signatures

Purpose Gene expression profiling for outcome prediction of non–small-cell lung cancer (NSCLC) remains clouded by heterogeneous and unvalidated results. This study applied multivariate approaches to identify and evaluate value-added gene expression signatures in two types of NSCLC. Materials and Methods Two NSCLC oligonucleotide microarray data sets of adenocarcinoma and squamous cell carcinoma were used as training sets to select prognostic genes independent of conventional predictors. The top 50 genes from each set were used to predict the outcomes of two independent validation data sets of 84 and 91 NSCLC cases. Results Adenocarcinomas with the 50-gene signature from adenocarcinoma in both validation data sets had a 2.4-fold (95% CI, 1.3 to 4.4 and 1.0 to 5.8) increased mortality after adjustment for conventional predictors. Squamous cell carcinoma with this high-risk signature had an adjusted risk of 1.1 (95% CI, 0.4 to 3.2) in one data set and 2.5 (95% CI, 1.1 to 5.8) in another consisting of stage I tumors. Adenocarcinoma with the 50-gene signature from squamous cell carcinoma had an elevated risk of 3.5 (95% CI, 1.4 to 9.0) after adjustment for conventional predictors. Squamous cell carcinoma with this high risk signature had an adjusted risk of 1.8 (95% CI, 0.7 to 4.6). Despite the little overlap in individual genes, the two gene signatures had significant functional connectedness in molecular pathways. Conclusion Two non-overlapping but functionally related gene expression signatures provide consistently improved survival prediction for NSCLC regardless of histologic cell type. Multiple sets of genes may exist for NSCLC with predictive value, but ones with independent predictive value beyond clinical predictors will be required for clinical translation.

scholarly journals Papillary squamous cell carcinoma of antrum-clear cell variant

2014 ◽  
Vol 18 (1) ◽  
pp. 146
Author(s):  
SangeetaR Patankar ◽  
V Poornima ◽  
Vineet Avdhani ◽  
Sanya Bhatia
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Clear Cell ◽  
Papillary Squamous Cell Carcinoma ◽  
Cell Variant ◽  
Clear Cell Variant

scholarly journals Split thickness skin graft in active psoriasis in patient with clear cell variant squamous cell carcinoma

2019 ◽  
Vol 12 (9) ◽  
pp. e231295 ◽  
Author(s):  
Lisa Scupham ◽  
Atul Ingle
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Clear Cell ◽  
Skin Grafting ◽  
Split Thickness Skin Graft ◽  
Thickness Skin ◽  
Split Thickness Skin Grafting ◽  
Cell Variant ◽  
Clear Cell Variant

The case report discusses split thickness skin grafting in a patient with active psoriasis. This also reports a case of a rare variant of squamous cell carcinoma.

Sign in / Sign up

Export Citation Format

Share Document