Anesthetic Agent

2020 ◽  
Author(s):  
Keyword(s):  
Anesthetic Agent

scholarly journals Anesthetic agent etiomidate induces apoptosis in N2a brain tumor cell line

2018 ◽  
Author(s):  
Hong‑Tao Chen ◽  
Jun Zhou ◽  
You‑Ling Fan ◽  
Chun‑Liang Lei ◽  
Bao‑Jin Li ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Tumor Cell ◽  
Cell Line ◽  
Tumor Cell Line ◽  
Anesthetic Agent ◽  
Brain Tumor Cell ◽  
Brain Tumor Cell Line

Amitriptyline Neurotoxicity

2004 ◽  
Vol 100 (6) ◽  
pp. 1519-1525 ◽  
Author(s):  
Jean-Pierre Estebe ◽  
Robert R. Myers
Keyword(s):  
Nervous System ◽  
Sciatic Nerve ◽  
Local Anesthetic ◽  
Dose Range ◽  
Antidepressant Drug ◽  
Nerve Fibers ◽  
Anesthetic Agent ◽  
Sprague Dawley ◽  
Neurotoxic Effect ◽  
Local Anesthetic Agent

Background Amitriptyline is a tricyclic antidepressant drug used systemically for the management of neuropathic pain. Antidepressants, as a class of drugs with direct neurologic actions, are becoming widely used for the management of chronic pain, although their mechanisms are not entirely understood. Amitriptyline exerts potent effects on reuptake of norepinephrine and serotonin and blocks alpha 2A adrenoreceptors and N-methyl-D-aspartate receptors. Because amitriptyline is also a particularly potent blocker of sodium channels and voltage-gated potassium and calcium channels, it has been recommended as a long-acting local anesthetic agent. Unfortunately, amitriptyline has significant toxic side effects in the central nervous system and cardiovascular system that are dose-related to its systemic administration. Therefore, before amitriptyline can be used clinically as a local anesthetic agent, it should be thoroughly explored with respect to its direct neurotoxic effect in the peripheral nervous system. Methods The left sciatic nerve of Sprague-Dawley rats (12/ group) received a single topical amitriptyline dose of 0.625, 1.25, 2.5, or 5 mg; a saline group (n = 2) was used as control. Neuropathologic evaluations were conducted in separate animals (n = 4) 1, 3, and 7 days later. Results Amitriptyline topically applied in vivo to rat sciatic nerve causes a dose-related neurotoxic effect. Drug doses of 0.625-5 mg all caused Wallerian degeneration of peripheral nerve fibers, with the number of affected fibers and the severity of the injury directly related to the dose. Conclusion Because the effective local anesthetic dose is within this dose range, the authors strongly recommend that amitriptyline not be used as a local anesthetic agent.

Inhaled anesthetic agent sedation in the ICU and trace gas concentrations: a review

2017 ◽  
Vol 32 (4) ◽  
pp. 667-675 ◽  
Author(s):  
Jennifer Herzog-Niescery ◽  
Hans-Martin Seipp ◽  
Thomas Peter Weber ◽  
Martin Bellgardt
Keyword(s):  
Anesthetic Agent ◽  
Trace Gas ◽  
Inhaled Anesthetic

scholarly journals The efficacy of eutectic mixture of local anesthetics as a topical anesthetic agent used for dental procedures: A brief review

2016 ◽  
Vol 10 (3) ◽  
pp. 383 ◽  
Author(s):  
SeyyedMohammad Abrisham ◽  
Alireza Daneshkazemi ◽  
Pedram Daneshkazemi ◽  
Amin Davoudi
Keyword(s):  
Local Anesthetics ◽  
Eutectic Mixture ◽  
Anesthetic Agent ◽  
Topical Anesthetic ◽  
Dental Procedures

A Study on the Efficacy of Ketamine Given Intrathecallyas A Spinal Anesthetic Agent

2017 ◽  
Vol 4 (1) ◽  
pp. 149-153
Author(s):  
Leelavathy P.B. ◽  
◽  
M. SalimIqbal ◽  
Junaid Ahmed Desai ◽  
Aditya Manjunath ◽  
...  
Keyword(s):  
Anesthetic Agent ◽  
Spinal Anesthetic
Sign in / Sign up

Export Citation Format

Share Document