scholarly journals Glycoprotein Hormones Alpha Chain Protein

2020 ◽  
Author(s):  
Keyword(s):  
Glycoprotein Hormones ◽  
Alpha Chain

ALPHA CHAIN OF GLYCOPROTEIN HORMONES

1974 ◽  
Vol 29 (8) ◽  
pp. 558-559
Author(s):  
R. BENVENISTE ◽  
J. BELL ◽  
J. KOEPPEL ◽  
K. RABINOWITZ
Keyword(s):  
Glycoprotein Hormones ◽  
Alpha Chain

scholarly journals A critical cytoplasmic domain of the interleukin-5 (IL-5) receptor alpha chain and its function in IL-5-mediated growth signal transduction.

1994 ◽  
Vol 14 (11) ◽  
pp. 7404-7413 ◽  
Author(s):  
S Takaki ◽  
H Kanazawa ◽  
M Shiiba ◽  
K Takatsu
Keyword(s):  
Signal Transduction ◽  
Protein Tyrosine Kinase ◽  
Cytoplasmic Domain ◽  
Beta Chain ◽  
Cytoplasmic Domains ◽  
Interleukin 5 ◽  
Alpha Chain ◽  
Gm Csf ◽  
Response Expression ◽  
And Function

Interleukin-5 (IL-5) regulates the production and function of B cells, eosinophils, and basophils. The IL-5 receptor (IL-5R) consists of two distinct membrane proteins, alpha and beta. The alpha chain (IL-5R alpha) is specific to IL-5. The beta chain is the common beta chain (beta c) of receptors for IL-3 and granulocyte-macrophage colony-stimulating factor (GM-CSF). The cytoplasmic domains of both alpha and beta chains are essential for signal transduction. In this study, we generated cDNAs of IL-5R alpha having various mutations in their cytoplasmic domains and examined the function of these mutants by expressing them in IL-3-dependent FDC-P1 cells. The membrane-proximal proline-rich sequence of the cytoplasmic domain of IL-5R alpha, which is conserved among the alpha chains of IL-5R, IL-3R, and GM-CSF receptor (GM-CSFR), was found to be essential for the IL-5-induced proliferative response, expression of nuclear proto-oncogenes such as c-jun, c-fos, and c-myc, and tyrosine phosphorylation of cellular proteins including JAK2 protein-tyrosine kinase. In addition, analysis using chimeric receptors which consist of the extracellular domain of IL-5R alpha and the cytoplasmic domain of beta c suggested that dimerization of the cytoplasmic domain of beta c may be an important step in activating the IL-5R complex and transducing intracellular growth signals.

Measurement of canine IgE using the alpha chain of the human high affinity IgE receptor

2001 ◽  
Vol 78 (3-4) ◽  
pp. 349-355 ◽  
Author(s):  
K. Stedman ◽  
K. Lee ◽  
S. Hunter ◽  
B. Rivoire ◽  
C. McCall ◽  
...  
Keyword(s):  
Ige Receptor ◽  
Alpha Chain ◽  
High Affinity ◽  
High Affinity Ige Receptor
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